Clinical trials: Metabolic Evaluation
Osteoarthritis, Obesity
Ultrasound Assessment of the Adventitia, Extra-media (EMT) and Veia Jugularis Interna Thickness
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- NCT03208881
- Testing
- Dietary Supplement: Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Henrik Gudbergsen
Diabetes Mellitus
Multiple Ascending Dose Study in Subjects With Type 2 Diabetes
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics following ascending multiple doses of AMG 876 in subjects with type 2 diabetes.
- Trial name
- NCT01856881
- Testing
- AMG 876
- Where
- 6 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Vitamin D Deficiency, Orthostatic Intolerance
Vitamin D Deficiency and Dysautonomia
In previous work the investigator identified a group of children between the ages of 10-18 years whose diagnostic workup for chronic nausea unexplained by conventional diagnostic tests has unexpectedly revealed underlying…
- Conditions
- Vitamin D Deficiency, Orthostatic Intolerance, Nausea
- Trial name
- NCT03032328
- Testing
- vitamin D supplement
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
NAFLD
Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)
evaluate the combined effects of Rutin and Vitamin C versus Vitamin C alone on selected oxidative stress markers, inflammation, hepatic steatosis regression, and associated metabolic parameters in patients with MASLD
- Trial name
- NCT07310407
- Testing
- Rutin + Vitamin C, Vitamin C 500mg, Lifestyle Intervention
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Chronic Kidney Diseases
Cardiometabolic Devices Accuracy Study
With the rise of cardiovascular diseases (CVD) and diabetes, the global disease burden is shifting towards non-communicable diseases (NCDs).
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Hyperlipidemias
- Trial name
- NCT05257564
- Testing
- Determine the accuracy of quantitative measurements of GLU, HbA1c,CHOL and CRE with POC devices compared to a laboratory reference method (Roche)
- Where
- Nepal
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Amyloidosis in Transthyretin (TTR), Amyloidosis, Familial
To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)
The AG10-504 study is an open-label extension study of acoramidis in participants with newly diagnosed transthyretin amyloid cardiomyopathy (ATTR-CM) or both ATTR-CM and transthyretin amyloid polyneuropathy (ATTR-PN).
- Conditions
- Amyloidosis in Transthyretin (TTR), Amyloidosis, Familial, Amyloid Cardiomyopathy, Amyloid Cardiomyopathy, Transthyretin-Related
- Trial name
- NCT07116473
- Testing
- Acoramidis (AG10)
- Volunteers
- 250 people
- Sponsor
- Eidos Therapeutics, a BridgeBio company
Fabry Disease
A Study to Evaluate the Effect of Venglustat Tablets on Neuropathic and Abdominal Pain in Male and Female Participants ≥16 Years of Age With Fabry Disease
This is a 12-month, parallel treatment, Phase 3, double-blind, randomized, placebo-controlled study to evaluate the effect of venglustat on neuropathic and abdominal pain symptoms of Fabry disease in participants ≥16 years of age…
- Trial name
- PERIDOT (NCT05206773)
- Testing
- Venglustat (GZ402671)
- Where
- 50 sites in United States, Argentina and 19 more
- Volunteers
- 122 people
- Sponsor
- Sanofi
Healthy
A Clinical Trial to Evaluate the Pharmacokinetics and Safety of SIPS-2209-1 in Healthy Korean Volunteers
The goal of this clinical trial is to evaluate of bioequivalence between fixed-dose combination and co-administration of the individual components under fasting conditions in healthy Korean volunteers.
- Trial name
- NCT05787873
- Testing
- SIPS-2209-1, SIPS-2209-2, SIPS-2209-3
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samik Pharmaceutical Co. Ltd.
Obesity
Protocol for the Assessment of Variability in Histology and Gene Expression in Bariatric Surgery Patients.
It is known that a vast majority of patients seeking a bariatric surgery weight reduction procedure have non-alcoholic fatty liver disease (NAFLD), while a smaller subset of patients within this group have a more serious liver…
- Trial name
- NCT00280527
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Northwestern University
Obesity, Bariatric Surgery Candidate
Examination of Cognitive Function in Obesity and Following Weight Loss
Bariatric surgery is the most effective, long-term treatment for morbid obesity, and consistent with previous findings, individuals who lose significant weight after surgery also have improved cognition or "brain function".
- Conditions
- Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT02994186
- Testing
- Bariatric Surgery, Medical Weight Loss Program
- Sponsor
- Vanderbilt University Medical Center
Metabolic Syndrome
Assessment of Therapeutic Potential of Stigma Maydis (Cornsilk) on Metabolic Syndrome
Over the past two decades, there has been an increase in the number of people with nutrition related maladies due to changes in their dietary habits and lifestyle.
- Trial name
- cornsilk (NCT06240273)
- Testing
- Corn silk powder
- Volunteers
- 50 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Obesity
Tangji Gastric Bypass Stent Study for Obesity
The Gastric Bypass Stent System is intended to be used in weight loss treatment for obesity in patients with a BMI ≥ 30 kg/m2. In this clinical investigation the Sponsor seeks to demonstrate the safety and performance of the…
- Trial name
- NCT05938231
- Testing
- Gastric Bypass Stent System, Dietary Intervention
- Where
- 7 sites in China
- Volunteers
- 99 people
- Sponsor
- Hangzhou Tangji Medical Technology Co., Ltd.
Renal Failure
A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function
A study to evaluate the drug effect, safety, and tolerability of BMS-986259 in participants with different levels of kidney function
- Trial name
- NCT04237831
- Testing
- BMS-986259
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Type 2 Diabetes
Evaluation of Diabetes Care at Austrian GPs
This registery should show the medical care of patient with Type 2 Diabetes (T2D) at GP-offices. Furthermore data of co morbidities and risk factors should be evaluated.
- Trial name
- DCA09 (NCT00979394)
- Volunteers
- 1,513 people
- Sponsor
- AstraZeneca
Hyperkalaemia
A Multicenter, Prospective, Non-interventional Cohort Study to Evaluate the Safety and Treatment Pattern of Sodium Zirconium Cyclosilicate for Hyperkalaemia Management in Real World Practice in China
The study is a multi-center prospective (primary data) non-interventional cohort study which enrolls 1500 patients including new and ongoing users on SZC at Study Enrollment Day in real-world clinical practice.
- Trial name
- ACTUALIZE (NCT05271266)
- Where
- 27 sites in China
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Phenylketonurias, PAH Deficiency
Gene Therapy Clinical Study in Adult PKU
This is a Phase 1/2, open-label, randomized, concurrently-controlled, dose escalation study to evaluate the safety and efficacy of HMI-102 in adult PKU subjects with PAH deficiency.
- Trial name
- pheNIX (NCT03952156)
- Testing
- HMI-102
- Where
- 13 sites in United States
- Volunteers
- 10 people
- Sponsor
- Homology Medicines, Inc
Type 2 Diabetes Mellitus
Japanese Phase 1 Multiple Ascending Dose Study
The purpose of this clinical study is to assess the safety and tolerability of multiple oral doses of BMS-823778 in healthy Japanese subjects and Japanese patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT01515202
- Testing
- BMS-823778
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Metabolic Associated Fatty Liver Disease
Benefits of Trimetazidine in MASLD Patients
Objective of this study is to determine the clinical benefits of trimetazidine in improvement of MASLD
- Trial name
- MASLD (NCT06140953)
- Testing
- Trimetazidine, Conventional therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Hypertension, Diabetes
Assessing Open Access Audio
The medical encounter can be overwhelming in term of the amount of information discussed, its technical nature, and the anxiety it can generate.
- Trial name
- OAA (NCT04452331)
- Testing
- Open Access Audio, No Access, Patient and Provider Aware of Recording, No Access, Provider Unaware of Recording
- Where
- 2 sites in United States
- Volunteers
- 1,553 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Arterial Calcification, CD73 Deficiency
Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)
Background: Arterial Calcifications due to Deficiency in CD73 (ACDC) is a rare genetic disease. People with ACDC develop calcification in the arteries of the lower extremities as well as calcium deposit in the joints of the…
- Trial name
- NCT01585402
- Testing
- Etidronate, MRI Scan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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