Clinical trials: Metabolic Evaluation
Type 2 Diabetes Mellitus
Pharmacokinetics and Pharmacodynamics of MK-8245 in Participants With Type 2 Diabetes (MK-8245-012)
This study will assess the safety, tolerability, pharmacokinetics, and glucose lowering activity of MK-8245 in participants with type 2 diabetes.
- Trial name
- NCT00972322
- Testing
- MK-8245
- Volunteers
- 56 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity
A Study of LY3532226 in Participants With Obesity
The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY3532226 in participants with obesity.
- Trial name
- NCT06557356
- Testing
- LY3532226
- Where
- 4 sites in United States, Singapore
- Volunteers
- 132 people
- Sponsor
- Eli Lilly and Company
Erythropoietic Protoporphyria
Study of Bitopertin to Evaluate the Safety, Tolerability, Efficacy, and PPIX Concentrations in Participants With EPP
This is a Phase 2, multi-center, double-blind, placebo-controlled, parallel group study of bitopertin to evaluate the safety, tolerability, efficacy, and PPIX concentration change in participants with EPP.
- Trial name
- NCT05308472
- Testing
- DISC-1459
- Where
- 9 sites in United States
- Volunteers
- 75 people
- Sponsor
- Disc Medicine, Inc
Diabetes Mellitus, Type 2
IMPACT Intervention
Introduction : The prevalence of type 2 diabetes is increasing in France, especially in deprived districts. The Itineraires Medico-sociaux Programme d'Accompagnement sur un Territoire (IMPACT) intervention is intended for…
- Trial name
- NCT04616053
- Testing
- IMPACT intervention
- Volunteers
- 140 people
- Sponsor
- Pole de Sante Chambery Nord
Healthy, Body Weight
IC-BASAROTs: New Practice Method for More Accurate Bed-side Assessment of Individual Energy Expenditure
Assessment of resting energy expenditure (REE) by indirect calorimetry (IC) in 1400 healthy individuals for arithmetical transformation into an bedside tool to estimate energy requirements in dietary practice (BASAROTs).
- Conditions
- Healthy, Body Weight, Overweight, Thinness
- Trial name
- NCT02682537
- Where
- 6 sites in Germany
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences Neubrandenburg
Hypertension, Diabetes Type 2
Evaluating the Effect of Aliskiren Versus HCTZ on Coronary Flow Reserve in Hypertensive Type II Diabetics
The purpose of this study is to assess the effect of Tekturna (aliskiren), in combination with an ACE and calcium channel blocker in hypertensive patients diagnosed with Type II diabetes.
- Trial name
- NCT00994253
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- United States
- Sponsor
- Corewell Health East
Geriatrics, Fragility
Evaluation of Metabolic Syndrome, Frailty, Locomotive Syndrome, Balance and Physical Fitness in Elderly Individuals
Metabolic syndrome (MetS) or syndrome X, which is increasingly prevalent in the world and in our country, is a disease that includes abdominal obesity, dyslipidemia, impaired glycemic control and hypertension components.
- Conditions
- Geriatrics, Fragility, Locomotor, Physical Fitness
- Trial name
- NCT05938153
- Testing
- observational physical tests
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Kırıkkale University
Cytomegalovirus Retinitis, HIV Infections
A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment Failure
To examine the usefulness and safety of the antiviral drug foscarnet in treating AIDS patients with cytomegalovirus (CMV) infection that is causing sight-threatening inflammation of the retina in one or both eyes (CMV retinitis).
- Trial name
- NCT00000691
- Testing
- Foscarnet sodium
- Where
- 11 sites in United States
- Volunteers
- 156 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1, Diabetes type1
Crocus Sativus Extract Impact in Metabolic Control of Patients With Diabetes Mellitus Type 1
Administration of 4 strain of probiotics, prebiotic, magnesium and crocus sativus extract in a sachet to people with diabetes mellitus type 1 for 6 months
- Trial name
- NCT05933460
- Testing
- dietary supplement with probiotics, prebiotics, magnesium and saffron extract, dietary supplement with probiotics, prebiotics, magnesium
- Where
- Greece
- Volunteers
- 61 people
- Sponsor
- Aristotle University Of Thessaloniki
Gaucher Disease
A Clinical Study for the Treatment of Pediatric and Adolescent Patients With Type 1 Gaucher Disease
The purpose of this study was to evaluate the safety, tolerability, efficacy, immunogenicity, PD and PK characteristics of LY-M001 injection in children with GD1 aged 6 years ≤ age < 18 years.
- Trial name
- NCT06528080
- Testing
- LY-M001
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Non-Insulin-Dependent Diabetes Mellitus
Study In Patients With Type 2 Diabetes Who Are Taking Metformin And Sulfonylurea, Metformin And Insulin, Or Insulin
This study will use Magnetic Resonance Imaging (MRI) techniques to evaluate changes in fluid volume in the lower legs of diabetic patients who add either pioglitazone or placebo to their current diabetic regimen.
- Trial name
- NCT00269061
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus
Assessment of Gastric Emptying by SHR20004 in Healthy Subjects
The purpose of this study is to investigate the impact of SHR20004 on the pharmacokinetic (PK) characteristics of acetaminophen in healthy subjects.
- Trial name
- NCT06137469
- Testing
- Acetaminophen/SHR20004
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Hyperlipidemias
HDDO-1756 Bio Equivalence Study
For healthy adult volunteers, safety and pharmacokinetic properties are compared between the two formulations in the case of HDDO-1756 alone administration and HDDO-17561/HDDO-17562 combined administration.
- Trial name
- NCT04755894
- Testing
- HDDO-1756, HDDO-17561/HDDO-17562
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hyundai Pharmaceutical Co., LTD.
Dyslipidemias
A Study of LY3475766 in Healthy Participants
This study will evaluate the safety and tolerability of LY3475766 when given to participants with high levels of blood fat called triglycerides.
- Trial name
- NCT04052594
- Testing
- LY3475766 - IV, LY3475766 - SC
- Where
- 4 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Iron-deficiency
Mechanism of Hypersensitivity Reactions to Iron Nanomedicines
Iron deficiency is common and when oral treatment is not sufficient intravenous application is indicated. Hypersensitivity to intravenous iron nanomedicines is rare but does occur and little is known about the underlying…
- Trial name
- NCT03508466
- Testing
- hypersensitivity reaction
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetus Mellitus, Diabetic Foot Ulcer
The Instant Effect of Whole Body Vibration in Diabetics
Overview of Diabetes and Its Complications: Diabetes is a chronic health issue that can lead to various complications, affecting human health negatively.
- Conditions
- Diabetus Mellitus, Diabetic Foot Ulcer, Diabetic Neuropathic Ulcer
- Trial name
- NCT06878651
- Testing
- The Whole Body Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Obesity
Evaluation of a Weight Management Program
This retrospective chart review and data abstraction will evaluate and quantify the effectiveness of a comprehensive weight management program.
- Trial name
- NCT00888251
- Testing
- Comprehensive weight management program
- Where
- 4 sites in United States
- Volunteers
- 153 people
- Sponsor
- Société des Produits Nestlé (SPN)
Diabetes Mellitus Type 2, Hypertension
Community Pharmacy Produce Prescriptions
The goal of this clinical trial is to generate evidence on the feasibility and effectiveness of community pharmacies as the implementers of a produce prescription program for adults with diabetes and/or hypertension.
- Trial name
- CP3 (NCT06920355)
- Testing
- Produce Prescription, Nutrition Education
- Where
- 3 sites in United States
- Volunteers
- 610 people
- Sponsor
- Tufts University
Diabetes, Hypertension
Evaluation of Exercise Benefits to Promote Health Aging Among Chronically Ill Geriatrics in a Community
The aim of this study is to evaluate the effect of hydraulic resistance circuit training for elderly people with chronic illness.
- Conditions
- Diabetes, Hypertension, Osteoporosis, Osteoarthritis
- Trial name
- NCT01754415
- Testing
- hydraulic resistance circuit training
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Dementia, Dementia, Vascular
Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
The goal of this clinical trial is to improve communication among clinicians, patients with memory problems, and their family members.
- Conditions
- Dementia, Dementia, Vascular, Mixed Dementias, Alzheimer Disease
- Trial name
- PICSI-M (NCT05596760)
- Testing
- Jumpstart Guide
- Where
- 3 sites in United States
- Volunteers
- 1,802 people
- Sponsor
- University of Washington
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