Clinical trials: Metabolic Evaluation
Type 2 Diabetes Mellitus, Medication Adherence
STUDIIO-Diabetes Pilot: STUdy of Drug Insurance to Improve Outcomes of Diabetes
Canada is the only country with a universal health insurance system that does not provide coverage for prescription drugs to all residents. One-third of working-age Canadians have no insurance.
- Conditions
- Type 2 Diabetes Mellitus, Medication Adherence, Medication Compliance, Medication Nonadherence
- Trial name
- NCT03804905
- Testing
- No-cost Medications
- Volunteers
- 144 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hypercholesterolemia
Evaluation of LDL Cholesterol in Patients Switched From 10 to 5 Milligrams of Zetia (Ezetimibe)
The purpose of this study is to compare the effect on LDL cholesterol levels of converting patients who are receiving the cholesterol absorption inhibitor Zetia at a dose of 10 milligrams to 5 milligrams, when prescribed as a…
- Trial name
- NCT00762229
- Testing
- Ezetimibe 10 mg, Ezetimibe 5 mg
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Bronx VA Medical Center
Vitamin C Deficiency
"Novo C Plus" Vitamin C Containing Dietary Supplement Bioavailability in Healthy Subjects
The aim of this study is to evaluate the bioavailability of "Novo C Plus" vitamin C containing dietary supplement compared to licensed vitamin C medications. The novelty of this product is the liposomal formulation.
- Trial name
- NCT02606773
- Testing
- Ascorbic Acid
- Where
- Hungary
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Hypertension With Metabolic Syndrome
Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic Syndrome
This proof of concept study is designed to evaluate the efficacy and safety of the combination therapy of aliskiren and ramipril as add-on to amlodipine in the treatment of patients with essential hypertension and metabolic…
- Trial name
- ALTO (NCT00542269)
- Testing
- Amlodipine, Aliskiren, Ramipril
- Where
- United Kingdom
- Volunteers
- 178 people
- Sponsor
- Novartis
Type 1 Diabetes Mellitus
Study of IMCY-0098 in Patients With Recent Onset Type 1 Diabetes
This clinical study will evaluate the safety of an innovative approach expected to be disease-modifying by stopping the auto-immune-mediated destruction of islet β-cells in the pancreas.
- Trial name
- NCT03272269
- Testing
- IMCY-0098
- Where
- 17 sites in Belgium, Denmark and 5 more
- Volunteers
- 41 people
- Sponsor
- Imcyse SA
Acute Gouty Arthritis, Gout Flare
Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare
A randomized, double-blind, international multicenter, colchicine and placebo-controlled study to evaluate the efficacy and safety of ABP-745 in subjects with acute gout.
- Conditions
- Acute Gouty Arthritis, Gout Flare, Gout Flares, Acute Gout Flare
- Trial name
- NCT07145229
- Testing
- ABP-745 Dose A, ABP-745 Dose B, Colchicine
- Where
- 38 sites in United States, Australia and 1 more
- Volunteers
- 479 people
- Sponsor
- Atom Therapeutics Co., Ltd
Emotional Disorder
Metabolic Activation of Brain Areas With Emotional Stimuli Compared With Score in Psychological Test
Quantitative assessment of the activation of brain areas by functional magnetic resonance imaging (fRMI) in the face of positive and negative emotional stimuli using audiovisual materials validated for the local population and…
- Trial name
- fMRI (NCT04974437)
- Where
- Argentina
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Instituto del Corazon, Argentina
Obesity
A Study to Evaluate Efficacy and Safety of HM11260C in Adult Obesity Patients Without Diabetes Mellitus
A multicenter, randomized, double-blind, phase 3 study to evaluate efficacy and safety of HM11260C in adult obesity patients without diabetes mellitus
- Trial name
- NCT06174779
- Testing
- HM11260C
- Where
- South Korea
- Volunteers
- 448 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Friedreich Ataxia
Efficacy, Tolerability, and Pharmacokinetics of Multiple Doses of Oral TAK-831 in Adults With Friedreich Ataxia
The purpose of this study is to evaluate the efficacy of TAK-831 versus placebo on upper extremity (arm and hands) motor function and manual dexterity.
- Trial name
- NCT03214588
- Testing
- TAK-831
- Where
- 6 sites in United States
- Volunteers
- 67 people
- Sponsor
- Neurocrine Biosciences
Obesity, Obstructive Sleep Apnea
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are receiving positive airway…
- Trial name
- MARITIME-OSA-1 (NCT07225686)
- Testing
- Maridebart cafraglutide
- Where
- 61 sites in United States, Australia and 9 more
- Volunteers
- 250 people
- Sponsor
- Amgen
Type 2 Diabetes Mellitus
A Pragmatic Randomized Trial to Evaluate the Comparative Effectiveness Between Dapagliflozin and Standard of Care in Type 2 Diabetes Patients
A trial of patients with type 2 diabetes mellitus to evaluate the comparative effectiveness between dapagliflozin and Standard of Care (SOC)
- Trial name
- DECIDE (NCT02616666)
- Testing
- Dapagliflozin, Standard of Care
- Where
- 132 sites in United Kingdom
- Volunteers
- 632 people
- Sponsor
- University of Liverpool
Phenylketonurias
Evaluation of PKU Sphere Liquid
PKU Sphere Liquid is a prospective, open-label, acceptability study to evaluate PKU sphere liquid in up to 15 participants aged 3 and above for the dietary management of PKU over 31 days.
- Trial name
- NCT05096988
- Testing
- PKU sphere liquid
- Where
- 3 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Vitaflo International, Ltd
Overweight or Obesity
A Study to Evaluate MWN109 Tablets in Healthy Adult Participants
This is a Phase 1, randomized, double-blind, placebo-controlled, single-and-multiple ascending dose study in which the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of orally administered…
- Trial name
- NCT06938269
- Testing
- MWN109 tablet
- Where
- 2 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
PreDiabetes, Impaired Fasting Glucose (IFG)
Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients.
This study evaluates the effect of different doses of metformin on the function of endothelium in people with pre-diabetes. One group of the patients will receive metformin in dose: 1500 mg, the second one will receive 3000…
- Conditions
- PreDiabetes, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT)
- Trial name
- NCT03398356
- Testing
- Metformin
- Where
- Poland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Healthy Male Participants
A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881
The purpose of this Phase I, open-label study is to evaluate the absorption, distribution, metabolism, excretion, absolute bioavailability, and to characterize the metabolites of AG-881 in healthy male participants following…
- Trial name
- NCT03960502
- Testing
- AG-881, [13C315N3]AG-881
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
PreDiabetes, Glucose Tolerance Impaired
A Study to Evaluate Efficacy and Safety of Distal Jejunal-release Dextrose Beads Formulation in Subjects With a Pathological Oral Glucose Tolerance Test
The primary purpose of the study is to evaluate the efficacy and safety of APHD-012 (distal jejunal-release dextrose [Aphaia technology, AT]) in participants with pre-diabetes (pathological Oral Glucose Tolerance Test (OGTT)).
- Trial name
- NCT05803772
- Testing
- APHD-012, APH-012P
- Where
- 3 sites in Slovakia
- Volunteers
- 31 people
- Sponsor
- Aphaia Pharma US LLC
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes Under Free Living Conditions
The main objective of this study is to determine whether home use of day and night closed loop insulin delivery under free living conditions applying faster insulin aspart (FiAsp) is non-inferior to home use of closed-loop…
- Trial name
- AP@Home04_P3 (NCT04055480)
- Testing
- Closed-loop using standard rapid-acting insulin, Closed-loop using faster insulin aspart
- Where
- 4 sites in Austria, Switzerland and 1 more
- Volunteers
- 25 people
- Sponsor
- University of Cambridge
Multiple Myeloma
VitD3 Supplementation in Patients With Multiple Myeloma
The goal of this clinical trial is to evaluate post-transplant immune reconstitution and lymphocyte recovery as well as the 3-year progression-free survival of patients with multiple myeloma in two treatment arms.
- Trial name
- NCT05846880
- Testing
- Lenalidomide, Maintenance Vitamin D, No maintenance Vitamin D
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Amany Keruakous, MD, MS.
Schizophrenia, Diabetes Mellitus
A Study of the Effects of Risperidone and Olanzapine on Blood Glucose (Sugar) in Patients With Schizophrenia or Schizoaffective Disorder
The purpose of this study is to assess and compare how risperidone and olanzapine, two antipsychotic medications, affect the regulation of glucose (sugar) in the body.
- Trial name
- NCT00236379
- Testing
- Olanzapine, Risperidone
- Volunteers
- 59 people
- Sponsor
- Janssen, LP
Hyperlipemia
A Study to Evaluate the Safety, Tolerability and Efficacy of Multiple Doses of JS002 in Patients With Hyperlipidemia..
JS002 is a recombinant humanized anti-PCSK9 monoclonal antibody.
- Trial name
- NCT04469673
- Testing
- Biological：JS002
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
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