Clinical trials: Metabolic Flexibility
Diabetes, Diabetes Mellitus, Type 1
Comparison of NN1250 With Insulin Glargine in Type 1 Diabetes
This trial is conducted in Europe and in the United States of America (USA). The aim of this trial is to investigate the efficacy and safety of NN1250 (insulin degludec) in subjects with type 1 diabetes.
- Trial name
- BEGIN™ (NCT01079234)
- Testing
- insulin degludec, insulin glargine, insulin aspart
- Where
- 82 sites in United States, Belgium and 5 more
- Volunteers
- 493 people
- Sponsor
- Novo Nordisk A/S
Metabolism
Validating a Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber
This study is designed to test the reliability of a novel procedure for measuring metabolic flexibility, i.e., the ability to quickly adapt macronutrient oxidation to macronutrient availability, in a respiratory chamber.
- Trial name
- METFLEX II (NCT05110274)
- Testing
- Overnight Metabolic Flexibility, Clamp Metabolic Flexibility
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Metabolic Health
ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks
The purpose of this study is to determine the impact of real-world shiftwork on metabolic flexibility.
- Trial name
- COMET (NCT05820490)
- Testing
- Whole Room Calorimeter, Mixed-Meal Tolerance Test (MMTT), Core Body Temperature
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Energy Metabolism
Muscle Energy Metabolism and Metabolic Flexibility in Older Men and Women
This study will explore differences in energy metabolism and metabolic flexibility under various conditions in older men and women.
- Trial name
- NCT03701867
- Testing
- Metabolic Flexibility Tests
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Hypopituitarism, Hydrocortisone
The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids in Patients With Corticotropic Hypopituitarism
This study aims at assessing the effect of today's standard of hydrocortisone dosage versus previous hydrocortisone dosage on flexibility and partitioning of ectopic lipid depots (IMCL and IHCL) after a standardised fat load…
- Conditions
- Hypopituitarism, Hydrocortisone, Lipids, Fatty Acids, Nonesterified
- Trial name
- Hydrocort (NCT02360046)
- Testing
- Hydrocortisone
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glucose Intolerance
Carnitine Supplementation in Type 2 Diabetic Patients
the results from animal studies and preliminary human studies show that carnitine availability and acetylcarnitine concentrations are low in insulin resistant states such as with type 2 diabetes mellitus.
- Trial name
- NCT03230812
- Testing
- Carnitene (L-Carnitine or Levocarnitine)
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Maastricht University Medical Center
Cognition, BDNF
Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism
The goal of this clinical trial is to learn if a state of ketosis and physical activity will increase serum BDNF concentrations and improve cognition, specifically in individuals who possess the Met allele from the BDNF Val66Met…
- Trial name
- NCT07218497
- Testing
- d-beta-hydroxybutrate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cancer, Breast Cancer
REstoring Metabolic FLEXibility Through Combined Exercise in Breast Cancer Survivors: A Randomized Controlled Trial.
The REFLEX study is a randomized, controlled clinical trial designed to evaluate the impact of a 16-week supervised, combined exercise program on metabolic flexibility and cardiorespiratory fitness in breast cancer survivors.
- Conditions
- Cancer, Breast Cancer, Neoplasm, Metabolic Flexibility
- Trial name
- REFLEX (NCT07405385)
- Testing
- Control, Exercise
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Castilla-La Mancha
Health Behavior
mACTonHEALTH: Psychological Flexibility and Activity Tracker - Protocol
Obesity and overweight are growing steadily and becoming a global epidemic. Recent researches report a 64% of the adult population as overweight.
- Trial name
- ACTonHEALTH (NCT03351712)
- Testing
- ACT-Based Intervention and Activity Tracker WITH Feedback, Gold Standard Intervention + Activity Tracker WITHOUT Feedback, Gold Standard Intervention and Activity Tracker WITH Feedback
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
Healthy Volunteers
Metabolic Flexibility as a Biomarker of Adaptation to Diet and Exercise Challenges
The objective is to develop a new metabolic flexibility biomarker, which has application in the study of changes diet and exercise on fuel management in humans.
- Trial name
- NCT01987388
- Testing
- High Intensity Exercise, Low Intensity Exercise, High Carbohydrate Beverage
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
Breast Cancer Female, Cardiometabolic Syndrome
Metabolic Flexibility and Autonomic Control After Muscle Power vs Metabolic Power Training in Postmenopausal Oncological Women: the POWER Health Study
POWER Health is a randomized clinical trial with a two-arm parallel design whose objectives are 1) to study metabolic flexibility and autonomic function (both capacities that describe cardiovascular health) in a sample of…
- Conditions
- Breast Cancer Female, Cardiometabolic Syndrome, Metabolism Disorder, Lipid, Autonomic Dysfunction
- Trial name
- POWER Health (NCT06336070)
- Testing
- HIIT program (8 weeks), MPI program (8 weeks)
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Valencia
Type 2 Diabetes, Overweight and Obesity
Acute Timed Exercise and 24h Metabolism
The primary objective of this randomized controlled cross-over study is to investigate if an acute, glycogen lowering exercise bout performed either in the morning or late afternoon differentially affects the respiratory exchange…
- Trial name
- TIM (NCT05073068)
- Testing
- Timing of exercise, Control
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Healthy, Metabolism
Improving Resilience With Whole Grain Wheat
This study investigates the health benefits of whole grain wheat on cardiovascular/ cardio-metabolic health, including glucose metabolism, by means of applying a mixed meal challenge.
- Trial name
- Graandioos (NCT02385149)
- Testing
- whole grain wheat, refined wheat
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Dilated Cardiomyopathy, Type 2 Diabetes
Myocardial Metabolism in Patients With Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments.
- Trial name
- NCT02440217
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Diabetes Mellitus, Type 2
Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber
The overarching aim of this study: To determine the effect of different meal compositions (high- vs. low-fat) on metabolic flexibility as it relates to meal-stimulated change in respiratory quotient (ΔRQ1) and sleep (ΔRQ2)…
- Trial name
- METFLEX (NCT03839641)
- Testing
- High fat meal, Low fat meal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
MINS
PeriOperative Medicine - Metabolic Inflexibility as a Mechanism for Myocardial Injury After Non-Cardiac Surgery
The goal of this observational study is to learn whether metabolic inflexibility, which means reduced ability of the body to switch between using fats and sugars for energy, is associated with myocardial injury after non-cardiac…
- Trial name
- POM-MIMICS (NCT07694453)
- Testing
- Pre-operative Metabolic Inflexibility
- Volunteers
- 300 people
- Sponsor
- University College, London
Glucose Intolerance
Acetylcarnitine and Metabolic Flexibility
Insulin resistant subjects and type 2 diabetic patients are characterized by a decreased metabolic flexibility: a reduced capability to switch from fat oxidation in the basal state to carbohydrate oxidation in the…
- Trial name
- NCT02072759
- Testing
- Carnitine supplement
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Emotional Eating, Emotion Regulation
ACT-Based Group Therapy and Mobile Application Intervention for Emotional Eating
This study aims to evaluate the effects of an Acceptance and Commitment Therapy (ACT)-based group therapy program, combined with an ACT-based mobile app, on emotional eating, emotion regulation, and psychological flexibility in…
- Conditions
- Emotional Eating, Emotion Regulation, Overweight, Psychological Flexibility
- Trial name
- ACT-EE (NCT07559552)
- Testing
- ACT-Based Group Therapy, ACT-Based Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
NAFLD - Nonalcoholic Fatty Liver Disease
Hepatic and Cardiac Metabolic Flexibility in Obese With NAFLD.
Non-alcoholic fatty liver disease (NAFLD) covers a spectrum from reversible hepatic steatosis to inflammation and fibrosis termed steatohepatitis (NASH) and cirrhosis.
- Trial name
- NCT03583437
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Underweight, Normal Weight Adults
Energy Metabolism and Eating Behavior in Underweight and Normal-weight Individuals
This study evaluates eating behavior and metabolic responses following consumption of a high-fat high-energy meal in healthy underweight and normal-weight adults.
- Trial name
- PROB I (NCT07671105)
- Testing
- High-fat high-energy meal
- Where
- Chile
- Volunteers
- 59 people
- Sponsor
- Jose Galgani