Clinical trials: Metabolic Health
Obesity
Females, Aging, Metabolism, and Exercise
This study is designed to determine whether a reduction in hormones (such as occurs during menopause) causes a decrease in calories burned during physical activity.
- Trial name
- FAME (NCT01712230)
- Testing
- GnRH agonist, Supervised cardiovascular exercise
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Cardiovascular Disease
SPREAD-NET: PRactices Enabling Adapting and Disseminating in the Safety NET
The investigators propose to compare the effectiveness of 3 strategies (low, medium, high intensity) at supporting CHCs' implementation of the ALL Initiative (an intervention shown to reduce patients' cardiovascular disease (CVD)…
- Trial name
- SPREAD-NET (NCT02325531)
- Testing
- Low support, Medium support, High support
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obesity, Overweight
Predicting Adherence to a Heart-Healthy Diet in Lean and Obese Individuals
Background: Sticking to a diet plan can be difficult, but is important for many different health reasons. Some people seem to have a harder time following and sticking to a diet plan than others.
- Trial name
- NCT01862796
- Testing
- Underfeeding diet, Weight maintaining diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiovascular Disease, Hypertension
Phase II Study of Heart Polypill Safety and Efficacy in Primary Prevention of Cardiovascular Disease
Cardiovascular is a major cause of mortality in Iran, accounting for 45.7% of deaths. In Golestan (North Eastern Iran) preliminary findings from follow-up of the Golestan Cohort are consistent with national figures: with 45% (at…
- Conditions
- Cardiovascular Disease, Hypertension, Hyperlipidemia, Heart Disease
- Trial name
- Polypill (NCT00603590)
- Testing
- Polypill
- Where
- Iran
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Metabolic Syndrome X
Efficacy Study Regarding the Beneficial Effects of Omega-3 Fatty Acids on Cardiometabolic Health
Fish oil supplements (which are rich in omega-3 fatty acids) have been shown to provide cardiometabolic benefits to individuals of all ages.
- Trial name
- FOHS (NCT02042274)
- Testing
- Fish oil supplement
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Obesity, Obesity, Childhood
Healthy Homes, Healthy Habits
The purpose of this study is to evaluate whether an intervention targeting healthy habit development reduces the risk and prevalence of obesity in low-income mothers and children.
- Conditions
- Obesity, Obesity, Childhood, Obesity; Familial
- Trial name
- HABITS (NCT03433456)
- Testing
- Home visitation + HABITS program, Standard home visitation program
- Where
- United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Diabetes
Using Practice Facilitation and Operationalizing Referral Information Technology to Increase DSMES Utilization
This is a pilot and feasibility study of a pragmatic cluster randomized trial that utilizes health information technology and practice facilitation to address referral barriers and increase clinician awareness and motivation to…
- Trial name
- NCT05472142
- Testing
- UP FOR IT - practice facilitation, UP FOR IT - health information technology
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mary Lacy
Obesity
EHR Embedded Comparative Effectiveness Studies--WWC
Randomize Everyone is a research project to develop new informatics systems and statistical methods for supporting randomization processes in EHR systems to do comparative effectiveness research.
- Trial name
- EHR-WWC (NCT04514679)
- Testing
- Dietician / Health Coach, Health Coach / Dietician
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Type II Diabetes, Primary Health Care
INTEGRATE-D: A Pilot Test to Support Integration of Medical and Psychosocial Care for People With Type II Diabetes
In 2016, the American Diabetes Association (ADA) published its first-ever recommendations for integrating medical and psychosocial care for patients with Type II Diabetes Mellitus (DMII) and common mental and behavioral health…
- Conditions
- Type II Diabetes, Primary Health Care, Behavioral Health
- Trial name
- NCT04461405
- Testing
- INTEGRATE-D
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus, Type 1
Estrogen and Diabetes
Diabetes has recently been referred to as "the epidemic of the 21st century". The reason why women with type 1 diabetes have a 2-3 fold greater risk of cardiovascular disease (CVD) compared to men with type 1 diabetes is…
- Trial name
- NCT03436992
- Testing
- Antioxidant Cocktail, Resveratrol
- Where
- 2 sites in United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Augusta University
Diabetes
Addressing Social Determinants of Health & Diabetes Self-Management in Vulnerable Populations
In this pilot and feasibility study, the investigator will randomize 100 African-American, Hispanic, and/or Medicaid (all race/ethnicities) patients from KPNW with A1C ≥ 8 to one of two 6-month interventions: 1) patient…
- Trial name
- NCT03802825
- Testing
- Diabetes Self-Management Training, Standard Patient Navigation
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Osteoporosis, Type 2 Diabetes Mellitus
Effect of Diabetic Medications on Bone Metabolism
Subjects with diabetes and pre-diabetes are said to have increased bone loss when compared to the general population. Pioglitazone a thiazolidinedione, is a Food and Drug Administration (FDA) approved oral anti-diabetic agent for…
- Trial name
- NCT00467285
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Psychological Distress, Cardiometabolic Syndrome
Shift-and-persist and Cardiometabolic Markers Among Women in Puerto Rico
The goal of this clinical trial is to evaluate the feasibility and acceptability of a 4-week mindfulness program among young women in Puerto Rico with elevated stress.
- Trial name
- NCT06250738
- Testing
- Mindfulness-based Stress reduction program: Virtual, Home exercises
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emory University
Pregnancy Complications
Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes
Pregnant women with type 2 diabetes mellitus (T2DM) are at increased risk for miscarriages, birth defects, large infants, and stillbirths. Maintaining blood sugars in the normal range decreases these pregnancy complications.
- Trial name
- NCT00678080
- Testing
- Metformin, Insulin (NPH and Regular)
- Where
- 3 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Vitamin d Deficiency
Blue Sky Study: Impact of Milk and Vitamin D for Child Growth and Health
This intervention study will address the impact of vitamin D fortified milk and vitamin D supplements on the growth, levels of vitamin D, insulin-like growth factor 1, growth hormone, academic attention, respiratory infections…
- Trial name
- BSS (NCT00886379)
- Testing
- Mongolian milk without vitamin D, Mongolian milk with vitamin D, UHT milk
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Overweight and Obesity
SMART 2.0: Social Mobile Approaches to Reducing weighT in Young Adults
The SMART 2.0 study is a 24-month trial designed to evaluate the impact of the intervention with technology and personal health coaching or with technology alone on objectively measured weight among overweight young adults in a…
- Trial name
- SMART 2 (NCT03907462)
- Testing
- SMART 2.0
- Where
- United States
- Volunteers
- 638 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Insulin Resistance
Vitamin D Supplementation to Obese Chinese Males
Hypothesis: Oral Supplementation of Vitamin D can Reduce Hypersecretion of Parathyroid Hormone and Insulin Resistance in Obese Chinese Males.
- Trial name
- NCT01781169
- Testing
- Oral supplementation of vitamin D
- Where
- China
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Aging, Sarcopenia
Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE)…
- Conditions
- Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases
- Trial name
- REALPA (NCT03771417)
- Testing
- Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Obesity
Multi-level Supermarket Discount Study
The study team's objective is to test the effect of supermarket discount levels on fruit and vegetable (F\&V) and non-caloric beverage purchasing and consumption, as well as health outcomes.
- Trial name
- NCT04178824
- Testing
- Discount Intervention
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai