Clinical trials: Metabolic Myopathies
Fibromyalgia, Duloxetine
Duloxetine Metabolism and Fibromyalgia
People with fibromyalgia report generalized body pain ("pain all over"), increased sensitivity to painful stimulation, chronic tiredness or low energy, sleep problems, and other physical and functional problems.
- Trial name
- DILIGENT (NCT06866444)
- Testing
- Observational
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Sjogren-Larsson Syndrome (SLS)
Sjogren-Larsson Syndrome: Natural History, Clinical Variation and Evaluation of Biochemical Markers
Sjogren-Larsson syndrome (SLS) is a rare genetic disease in which patients typically exhibit ichthyosis (dry, scaly skin), intellectual disability, spasticity, seizures and a distinctive maculopathy.
- Trial name
- SLS (NCT01971957)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders
This study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis, Myopathies, Stroke
- Trial name
- QUESST (NCT02118805)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Ultrasound Guided Injection
Ultrasound-guided Intervention and Hand Tenosynovitis in Patients With Diabetes Mellitus
Evaluates the efficacy of ultrasound guided versus clinically guided steroid injection in the management of tenosynovitis in DM patients.
- Trial name
- NCT03789526
- Testing
- ultrasound guidance
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Al-Azhar University
Amyloidosis, Trigger Finger
Cardiac Amyloidosis Screening at Trigger Finger Release
The investigators will prospectively evaluate for the presence of amyloid deposits in soft tissue samples obtained from patients undergoing trigger finger release surgery.
- Conditions
- Amyloidosis, Trigger Finger, Transthyretin Amyloidosis, Primary Amyloidosis of Light Chain Type
- Trial name
- CAST (NCT03886155)
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- The Cleveland Clinic
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mitochondrial Diseases, Kearns-Sayre Syndrome
Global Registry and Natural History Study for Mitochondrial Disorders
The main goal of the project is provision of a global registry for mitochondrial disorders to harmonize previous national registries, enable world-wide participation and facilitate natural history studies, definition of outcome…
- Conditions
- Mitochondrial Diseases, Kearns-Sayre Syndrome, MIDD, SANDO
- Trial name
- GENOMIT (NCT05554835)
- Where
- 34 sites in Austria, Germany and 1 more
- Volunteers
- 6,000 people
- Sponsor
- LMU Klinikum
Cancer, Diabetes
Identifying Therapeutic Factors in an 8-Week (30 Hour) Mindfulness-Based Stress Reduction (MBSR) Program
Since it's introduction in 1979 at the University of Massachusetts Medical Center by Dr. Jon Kabat-Zinn, Mindfulness-Based Stress Reduction (MBSR) has become a respected adjunct to conventional treatment for patients suffering…
- Conditions
- Cancer, Diabetes, Hypertension
- Trial name
- mbsr (NCT01599143)
- Testing
- Teaching Mindfulness-based Stress Reduction strategies
- Volunteers
- 135 people
- Sponsor
- North York General Hospital
Mitochondrial Diseases, Mitochondrial Myopathies
Human Mitochondrial Stress-driven Obesity Resistance
The overarching aim of this observational study is to determine alterations in energy balance while exploring the underlying cellular mechanisms in human genetic models of mitochondrial stress.
- Conditions
- Mitochondrial Diseases, Mitochondrial Myopathies, Mitochondrial Disorder
- Trial name
- MITO-OB-RES (NCT06080568)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mitochondrial Myopathy
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy
The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplement in adult-onset symptoms of mitochondrial myopathy.
- Trial name
- NCT05590468
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Ralitza Gavrilova
Lipin-1 Deficiency
International Multicenter Study on Lipin-1 Deficiency
LIPIN1 is an international registry that allows the collection of data on the follow-up, management and treatment of patients with Lipin-1 deficiency.
- Trial name
- LIPIN1 (NCT05564520)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Imagine Institute
Spinal Cord Injuries
The Effects of Spasticity on Glucose Metabolism in Individuals With Spinal Cord Injury
Muscle atrophy may occur in individuals with spinal cord injury (SCI) as a result of diminished physical activity and alterations in glucose metabolism and body composition may be seen.
- Trial name
- NCT03859960
- Testing
- body composition, glucose, insulin, glycohemoglobin
- Volunteers
- 33 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Cystinosis, Native Kidney
Cystinosis and Mitochondrial Metabolism
Cystinosis is a monogenic autosomal recessive lysosomal storage disease with complete penetrance, caused by a biallelic mutation in the CTNS gene (17p13.2) encoding cystinosin, a ubiquitous membrane protein whose role is to clear…
- Trial name
- CYSTI-MITO (NCT07319091)
- Testing
- Mitochondrial metabolism
- Where
- 9 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Eye Diseases Hereditary, Retinal Disease
Inherited Retinal Degenerative Disease Registry
The My Retina Tracker® Registry is sponsored by the Foundation Fighting Blindness and is for people affected by one of the rare inherited retinal degenerative diseases studied by the Foundation.
- Conditions
- Eye Diseases Hereditary, Retinal Disease, Achromatopsia, Bardet-Biedl Syndrome
- Trial name
- MRTR (NCT02435940)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Foundation Fighting Blindness
Muscle Loss, Muscle Weakness
Enhancing Muscle Health and Metabolism in Pre-frail Middle-aged and Older Adults
To evaluate the effects of protein-enriched soup plus exercise on muscle mass and muscle strength. Besides, the investigators use the valued-based healthcare standard set as well as the Center for Epidemiological…
- Trial name
- NCT05828134
- Testing
- protein-enriched soup
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Hypercholesterolemia, Myopathy
DNA Diagnostic System for Statin Safety and Efficacy
Lipitor®, Zocor®, and Crestor® are statin drugs commonly taken to lower cholesterol and prevent heart disease. Statins lower cholesterol by different amounts in different patients and sometimes statins cause muscle pain, cramps…
- Trial name
- SIM (NCT00767130)
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Genomas, Inc
Diabetes Mellitus, Type 2, Physical Activity
Effects of Measurement of Handgrip Strength on Physical Activity Level for Patients With Diabetes Type 2
Background: It is recommended that patients with diabetes type 2 keep themselves physically active and it is known that good muscular strength has a positive effect on these patients.
- Conditions
- Diabetes Mellitus, Type 2, Physical Activity, Muscular Weakness
- Trial name
- NCT03693521
- Testing
- Handgrip strength measurement, Standard care
- Where
- 7 sites in Sweden
- Volunteers
- 334 people
- Sponsor
- Göteborg University
Aging, Metabolism Disorder
The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle
The goal of this clinical trial is to test ketone bodies in healthy elderly and young individuals. The main question it aims to answer are: Do ketone bodies improve skeletal muscle function? Participants will ingest a ketone…
- Conditions
- Aging, Metabolism Disorder, Ketonemia, Muscle Disorder
- Trial name
- NCT05732909
- Testing
- D-β-hydroxybutyrate/D 1,3 butanediol monoester
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fibromyalgia, Mitochondrial Diseases
Heart Rate Variability in Response to Metformin Challenge
Diseases caused by brain energy supply defects can be innate (fibromyalgia secondary to familial mitochondrial disorders) or acquired (tardive dyskinesia or weight gain associated with prolonged antipsychotic use).
- Conditions
- Fibromyalgia, Mitochondrial Diseases, Movement Disorders, Diabetes Mellitus, Type 2
- Trial name
- NCT02500628
- Testing
- Metformin
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Woodinville Psychiatric Associates
Osteoporosis
1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
This 1-year open-label extension to CZOL446H2337 is designed to evaluate the safety and efficacy of zoledronic acid twice yearly in osteoporotic children treated with glucocorticoids.
- Trial name
- NCT01197300
- Testing
- Zoledronic acid
- Where
- 10 sites in Australia, Canada and 4 more
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals