Clinical trials: Metabolic Regulation
Type 2 Diabetes, Impaired Insulin Secretion
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans
Insulin resistance and the depletion of insulin secretion are major pathogenetic aspects of type 2 diabetes mellitus. Recently, inceptor, a receptor on the surface of beta cells was dicovered.
- Trial name
- NCT05575206
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes, Binge Eating
Improving Appetite Self-Regulation in African American Adults With Type 2 Diabetes
The purpose of this 6-month randomized clinical trial is to examine the feasibility of recruitment, attendance, retention, program adherence, and satisfaction of a digital application designed, Centering Appetite to improve…
- Trial name
- NCT05741125
- Testing
- DSME + ASE intervention (Centering Appetite)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Overweight and Obesity, Physical Activity
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
The purpose is to establish feasibility of delivering an individually-tailored, behavioral intervention to manage gestational weight gain [GWG] that adapts to the unique needs and challenges of overweight/obese pregnant women…
- Conditions
- Overweight and Obesity, Physical Activity, Weight Change, Body, Eating Behavior
- Trial name
- HMZ (NCT03945266)
- Testing
- Intervention group, Control group
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University
Celiac Disease
INF-α Innate Immune Response to Gliadin
Background \& Aims The enteropathy in Celiac Disease (CD) is due the adaptive and to the innate immune response to gliadin peptides.
- Trial name
- NCT03221647
- Testing
- Intestinal biopsies
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Federico II University
Healthy Obesity, Metabolically, Appetite Regulation
Colonic Propionate, Appetite, and Weight Loss
The current protocol aims to investigate the impact of the propionate ester in conjugation with restricted diet on appetite and weight loss.
- Trial name
- ProAp (NCT03322514)
- Testing
- Inulin-Propionate Esters, Inulin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Type 2 Diabetes
High-amylose Barley (HIAMBA) in the Regulation and Prevention of Type 2 Diabetes
In a series of double-blinded randomized cross-over acute studies, the investigators want to study the effects of naturally produced high-amylose barley (Lean-baking barley®) on the postprandial glucose-metabolism in subjects…
- Trial name
- NCT04702672
- Testing
- 100% wheat (control), 100% Lean-baking barley®, 100% regular barley
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Insulin Resistance
The Effect of Vasopressin on Glucose Regulation
Data from experimental animals and human epidemiological studies have suggested that hypohydration and/or low water intake is linked to poor glucose regulation and diabetes.
- Trial name
- HYPERGlu (NCT02761434)
- Testing
- Hypertonic Saline (3% NaCl), Isotonic Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Obesity
Metacognitive Beliefs in Obese Patients
The study aims to investigate the presence of metacognitive beliefs, emotional regulation, and emotional eating in obese patients and their possible relationships.
- Trial name
- METAOBES (NCT06800911)
- Testing
- Questionnaires
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Istituto Auxologico Italiano
Sodium Excess, Racial Disparities
Vascular Effects of Acute Sodium (VEAS) Study
This IRB will cover a current clinical trial (NCT04244604) that was started at Auburn University (AU IRB#19-390), the Principal Investigator's prior institution, and is supported by his NIH Career Development Award (NHLBI…
- Conditions
- Sodium Excess, Racial Disparities, Blood Pressure, Cardiovascular Risk Factor
- Trial name
- NCT04244604
- Testing
- Low Sodium Meal (140 mg sodium chloride), High Sodium Meal (2500 mg sodium chloride)
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2
The Effect of Esomeprazole on Type 2 Diabetes
The investigators aimed to prospectively investigate the effects of esomeprazole on glycaemic control in patients with type 2 diabetes mellitus. The investigators also aimed to associate this effect with gastrin levels.
- Trial name
- NCT03598738
- Testing
- Esomeprazole 40mg
- Volunteers
- 32 people
- Sponsor
- Baskent University Ankara Hospital
Obesity, Diabetes
Fibre and Appetite Regulation Trial (FART)
High intake of cereal fibre has been shown to be associated with reduced weight gain and improved insulin sensitivity. We hypothesize these effects are due to the short chain fatty acids derived from the bacterial fermentation…
- Trial name
- NCT00247455
- Testing
- Low fibre breakfast cereal (puffed rice/cornflakes), High fibre cereal (All Bran/Bran Flakes)
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Overweight and/or Obesity
Body-Based and Mind-Based Regulation in Overweight and Obese Women
This study will compare two regulation-based approaches in women with overweight or obesity. The first approach is a body-based regulation program including breathing awareness, body-awareness-based yoga practices, non-invasive…
- Trial name
- NCT07738263
- Testing
- Body-Based Regulation Program, Mind-Based Regulation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Pamukkale University
Post Prandial Blood Glucose, Gut Microbiota
Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects
The overall aim is to investigate the intake of beta-glucan in relation to glucose metabolism and satiety in a postprandial study with healthy subjects.
- Conditions
- Post Prandial Blood Glucose, Gut Microbiota, Satiety
- Trial name
- NCT03293693
- Testing
- 0.5 g beta-glucan, 3.5 g beta-glucan, 8 g beta-glucan
- Where
- Norway
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Chronic Kidney Diseases, Chronic Heart Failure
Iron Deficiency and FGF23 Regulation in CKD and HF
This study investigates the effects of intravenous (IV) iron sucrose therapy on blood levels of Fibroblast Growth Factor 23 (FGF23, a protein that regulates the amount of phosphate in the body) in iron deficiency anemia in…
- Conditions
- Chronic Kidney Diseases, Chronic Heart Failure, Iron Deficiency Anemia
- Trial name
- INDIGO (NCT03106298)
- Testing
- Iron Sucrose
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Prader Willi Syndrome, Syndromic Obesity
Prader-Willi Syndrome Macronutrient Study
The overall objective is to explore the mechanisms by which macronutrients regulate food intake and weight gain in Prader Willi Syndrome (PWS).
- Conditions
- Prader Willi Syndrome, Syndromic Obesity, Childhood Obesity
- Trial name
- NCT02011360
- Testing
- Low Carbohydrate diet, Low Fat diet
- Where
- 2 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- Duke University
Obesity, Sleep Restriction
Effects of Time of Sleep Restriction in Obesity
The purpose of this study is to determine the effect of different time of sleep restriction on control of food intake and metabolism of obese and normal subjects.
- Conditions
- Obesity, Sleep Restriction, Appetite Regulation, Eating
- Trial name
- NCT01259895
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Obesity, Appetite Regulation
ProSat - Long Term Effect of Probiotics on Satiety
The aim of the ProSat study is to examine the effects of a probiotic capsule containing Lb. Casei on subjective appetite sensation, ad libitum energy intake, and appetite hormone response in a single meal test and to determine…
- Trial name
- ProSat (NCT01240018)
- Testing
- Probiotic
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Growth Hormone Deficiency
Low Dose Growth Hormone (GH) on Insulin Sensitivity and Cortisol Production Rates
Study hypothesis: Growth hormone (GH), through its generation of free 'bioavailable' insulin-like growth factor (IGF)-I, can improve insulin sensitivity in adults with GH deficiency.
- Trial name
- NCT00517062
- Testing
- Growth hormone (Genotropin)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity and Overweight, Appetite Regulation
Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese Adults
Obesity is a global health crisis affecting over 2.3 billion individuals worldwide. This prospective study aims to evaluate the comparative effects of standardised Cissus quadrangularis extract (CQE) and Dichrostachys glomerata…
- Trial name
- NCT06827002
- Testing
- Dichrostachys glomerata, Cissus quadrangularia, Dextrin
- Where
- Cameroon
- Volunteers
- 248 people
- Sponsor
- University of Yaounde 1