Clinical trials: Metabolic Regulation
Hepatic Steatosis, Polycystic Ovarian Syndrome
Liver and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance.
- Conditions
- Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
- Trial name
- APPLE (NCT02157974)
- Testing
- Byetta 5Mcg Pen Injection
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertriglyceridemia
Regulation of Sterol Homeostasis
The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.
- Trial name
- NCT00018720
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Obesity, Appetite
Brain Regulation of Appetite in Twins
Scientists are examining the genetic and environmental influences on appetite and weight gain. The main purpose of this study is to look at how genetic and environmental factors may influence how the brain regulates appetite and…
- Trial name
- BRAT (NCT02483663)
- Testing
- Functional Magnetic Resonance Imaging, Dual Energy X-ray absorptiometry, Questionnaires
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Washington
Coronary Artery Disease, Type 2 Diabetes Mellitus (T2DM)
Effects of Fecal Microbiota Transplantation in Patients With Type 2 Diabetes and Coronary Artery Disease (CAD-Microbiome) - A Pilot Study
This pilot study investigates whether fecal microbiota transplantation (FMT) can modify the gut microbiome in patients with type 2 diabetes mellitus and stable coronary artery disease (CAD).
- Trial name
- CAD-Microbiome (NCT07421947)
- Testing
- Fecal Microbiota Transplantation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Diabetes, Obesity
Role of Methane in Glycemic Control
The purpose of this study is to determine how certain types of bacteria in the human gut may affect weight gain, and contribute to the development of diabetes.
- Trial name
- NCT01638429
- Testing
- Neomycin, Rifaximin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Blood Glucose Concentration, Blood Glucose Self Monitoring
Effect of Low Water Intake on Glucose Regulation Measured Using Continuous Glucose Monitoring
This clinical trial aims to learn if increasing water intake for five days can lower blood glucose in healthy, free-living individuals.
- Trial name
- NCT06645431
- Testing
- Water Intake
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Insulin Secretion, Insulin Resistance
Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 Diabetics
1. The purpose of this study is to determine whether Sitagliptin therapy suppress glucagon release and improve glucose control in Chinese type 2 diabetic. 2.
- Trial name
- NCT01610154
- Testing
- Sitagliptin
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Guangwei Li
Polycystic Ovarian Syndrome (PCOS)
Time Restricted Feeding Model in Women With Polycystic Ovary Syndrome
This study aims to evaluate the effects of a 16:8 time-restricted feeding (TRF) model on anthropometric, metabolic, and hormonal parameters in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT06807775
- Testing
- Dietary Intervention (time-restricted feeding model (16:8)), Dietary Intervention (energy restricted dietary intervention)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
COVID-19, Diabetes Mellitus
Insulin Regulation and Severity of Severe Acute Respiratory Syndrome COVID-19 Infection
The Coronavirus Disease of 2019 (COVID-19) pandemic has caused an international healthcare crisis and produced a large healthcare burden.
- Conditions
- COVID-19, Diabetes Mellitus, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- NCT05897528
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 589 people
- Sponsor
- Arrowhead Regional Medical Center
Obesity
Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
The purpose of this study is to learn more about how diet affects the hormone ghrelin. Ghrelin is made in the stomach and causes appetite to increase.
- Trial name
- NCT00694512
- Testing
- Low fat diet, High fat diet, MCT diet
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity
Physical Activity and Food Intake Interaction: Effect of Weight Loss in Obese Adolescent
In obese adolescents, energy expenditure (EE) of chronic high intensity muscular exercise (> 70% VO2max) conducted one hour before a meal causes an anorectic effect at lunch and dinner the same day.
- Trial name
- NCT02664844
- Testing
- Physical activity
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Physiological Effect of TCC on Glucose Metabolism
Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function
The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners.
- Trial name
- NCT03503084
- Testing
- Classical Yang's TCC exercise
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Obesity, Overweight
The Effect of Sodium Alginate on Appetite Sensation
The aim of the study is to investigate the effects of a low-calorie alginate containing fruit flavored beverage on appetite and body weight development.
- Trial name
- B247Algobes (NCT01101633)
- Testing
- Alginate
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
The Effects of Exercise on Appetite Regulation in Overweight/Obese Individuals
In this study the Investigators are examining the effects of a 12-week exercise program (intervention) on measures of appetite and food intake regulation in overweight to mildly obese healthy adults.
- Trial name
- NCT02047721
- Testing
- Exercise, Diet
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gestational Hypertension
Role of the Oral Microbiome in Blood Pressure Regulation in Pregnancy
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby, increasing the risk of pregnancy complications including pre-eclampsia, fetal growth restriction and preterm birth.
- Trial name
- NCT03930693
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Hypercholesterolemia, Coronary Heart Disease
Comparison of Low and High Phytosterol Diets With Respect to Cholesterol Metabolism
The objective of this study is to compare cholesterol absorption and metabolism after feeding diets naturally low or high in phytosterols. All meals will be prepared in a metabolic kitchen and analyzed for phytosterols.
- Trial name
- Phyteaux-II (NCT00860509)
- Testing
- Low Phytosterol and High Phytosterol Diets
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Adolescent Obesity, Weight Loss
Teen Weight Control
The prevalence of obesity in adolescents is remarkably high, with 38.7% of youth 12-15 years of age and 41.5% of 16-19 year olds meeting criteria for overweight or obesity.
- Trial name
- HealthTRAC (NCT04861636)
- Testing
- HealthTRAC, SBWC
- Where
- 3 sites in United States
- Volunteers
- 172 people
- Sponsor
- The Miriam Hospital
Metabolic Flexibility
Human Metabolic Flexibility: Its Role in Energy Regulation and Obesity
Obesity is commonly described as a consequence of excess calorie intake. Conventionally, the physiological variables that have been of extensive interest are food intake and energy expenditure.
- Trial name
- NCT04773132
- Testing
- Low Protein
- Where
- Singapore
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Hyperglycaemia (Non Diabetic), Prediabetes
Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover…
- Trial name
- PORK (NCT06025292)
- Testing
- Lean Pork vs Plant-Based Protein
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas