Clinical trials: Metabolic Regulation
Resilience, Cognitive Function and Well-Being
Aging Resilience Through Microbiota Optimization and Regulation
Sarcopenia, characterized by the progressive loss of muscle mass and strength in older adults, is a key factor in health deterioration.
- Conditions
- Resilience, Cognitive Function and Well-Being, Muscle Function, Handgrip Strength Test, Insulin Sensitivity
- Trial name
- ARMOR (NCT06649981)
- Testing
- FMT capsule
- Where
- 2 sites in Chile
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gonzalo Jorquera, PhD
Obesity
Compare Effects of a Soluble Fiber on Weight and Blood Cholesterol
Obesity and type 2 diabetes have clearly been linked together and identified as epidemics in much of the developed world. Historically several different dietary fibers have been used as means of reducing body weight and the…
- Trial name
- NCT00682916
- Testing
- Y288
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Obesity
Appetite Regulation by Human Chemosignals From Tears and Plasma
Obesity is closely related to metabolic diseases and its prevalence is sharply increasing. However, there is no safe and effective treatment for obesity so far, the investigators need a breakthrough idea to curtail the constant…
- Trial name
- NCT01389869
- Testing
- Sniffing emotional tears, Sniffing trickled saline, Sniffing fasting plasma
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hyperglycemias, Prediabetes
Efficacy of the pA1c®HI Postbiotic in Metabolic Regulation in Healthy Individuals With Hyperglycemia
This study will evaluate the effects of pA1c®HI, a heat-inactivated postbiotic derived from the bacterium Pediococcus acidilactici, on blood glucose regulation and other aspects of metabolic health in adults with elevated blood…
- Trial name
- CR2027 (NCT07903870)
- Testing
- Postbiotic
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genbioma Aplicaciones SL
Lipodystrophy, Insulin Resistance
Insulin Regulated Amino Peptidase in Patients With Familial Lipodystrophy of DUNNIGAN
Familial Partial Lipodystrophy type 2 (FPLD2) is a heterogeneous group of rare lipodystrophy due to autosomal dominant mutation in LMNA encoding Lamin A/C.
- Trial name
- IRAP-DUN (NCT04578379)
- Where
- Reunion
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Cryotherapy, Training
Short to Long Effects of Whole Body Cryostimulation on Insulin Sensitivity Among Overweight
Therapeutic effectiveness of coldness in relieving pain and reducing inflammation has been known for many years now. Over that time, various coldness therapies have gained in popularity, including winter swimming, snow baths or…
- Conditions
- Cryotherapy, Training, Overweight, Insulin
- Trial name
- NCT04375969
- Testing
- whole body cryostimulation treatment, Connection WBC treatment and HIIT training, Control Group
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Glycemic Response to Feeding in Healthy Participants, Postprandial Amino Acid Concentrations
Comparison of Dairy and Plant-based Alternatives in Adolescents and Older Adults
The purpose of the Dairy vs Plant study is to compare the effects of dairy and plant-based alternative products on blood sugar regulation and nutrient quality in adolescents and older adults.
- Conditions
- Glycemic Response to Feeding in Healthy Participants, Postprandial Amino Acid Concentrations, Appetite Regulation
- Trial name
- NCT06874400
- Testing
- Dairy, Plant-based alternative
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Atherosclerosis
Characterizing PAI-1 Modulation on Monocyte Adhesion
To determine how altering the expression of a gene known as PAI-1 may affect the adhesive capacity of cells that play a critical role in the developement of human atherosclerosis.
- Trial name
- NCT00512031
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Aging, Glucose Intolerance
Regulation of B-Cell Function & Glucose Tolerance in Older People
This VA CDA-2 proposal will test in detail if lifestyle intervention with aerobic exercise training improves the body's production of insulin in older people at risk to develop diabetes.
- Trial name
- NCT00554112
- Testing
- Exercise
- Volunteers
- 90 people
- Sponsor
- US Department of Veterans Affairs
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dyslipidemia
Regulation of Intestinal and Hepatic Lipoprotein Production by Glucagon Like Peptide 2
1. To assess whether Glucagon like peptide 2 (GLP-2) affects lipoprotein production (study A) 2. To assess whether GLP-2 affects the release of preformed chylomicrons (study B)
- Trial name
- NCT01958775
- Testing
- GLP-2
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Obesity, Eating Disorders
A Brief Appetite Awareness Intervention for Eating and Weight Regulation Among College Freshmen
The proposed study is a randomized clinical trial investigating the effects of a weight gain and eating dysregulation prevention intervention among college freshmen women.
- Trial name
- NCT02496637
- Testing
- Appetite Awareness, Nutrition Education
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypoparathyroidism
Hypoparathyroidism Natural History Study
This is a prospective three-year natural history study of adults with hypoparathyroidism. The goal is to monitor patients with hypoparathyroidism to define end-organ damage in the context of the disease.
- Trial name
- SHINE (NCT05793853)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Appetite and General Nutritional Disorders
The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men
INTRODUCTION: Global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in…
- Trial name
- PROTEIN (NCT04876495)
- Testing
- Whey protein isolate, Potato protein isolate, Rice protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Obesity, Insulin Resistance
Inflammation Regulation in Obese Patients
Insulin resistance is one of the main mechanisms involved in metabolic diseases. inflammation has been implicated in its pathogenesis, due to innate immunity activation by free fatty acids, lipopolysaccharides (LPS) and lactate.
- Trial name
- NCT01561664
- Testing
- muscle and fat biopsy
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Depression, Insulin Resistance
Endogenous Opioid Activity and Affective State in Insulin Resistant Women
Insulin resistance, a primary component of the metabolic syndrome, is an escalating phenomenon in the United States, and confers an increased risk of depression and mood disorder, particularly in women.
- Conditions
- Depression, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT02069379
- Testing
- Metformin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Narcolepsy
Body Weight Regulation in Patients With Narcolepsy
This study will measure energy expenditure (the rate at which the body burns calories), physical activity and caloric intake in people with narcolepsy to learn more about how the risk of becoming overweight or diabetic may be…
- Trial name
- NCT00283894
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Malnutrition Elderly, Protein Malnutrition
The Effect of a Plant-based, Protein-dense Sauce on Essential Amino Acid Concentrations and Gut Fullness in Older Adults
The goal of this clinical trial is to determine whether meals fortified with plant-based high protein sauce (ProSauce) provide better metabolic availability of essential amino acids compared to meals with standard lower-protein…
- Trial name
- ProSauce (NCT06965699)
- Testing
- ProSauce, low-protein sauce
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Appetite
Metabolic Responses After 12-week Hypocaloric Diet Supplemented With a Cereal-based Plant Protein Biscuit
Biscuits enjoy high popularity in the human diet and can be excellent snack alternatives and potential carriers of ingredients with appetite regulating properties.
- Trial name
- NCT05213559
- Testing
- wheat biscuit enriched with plant proteins, common wheat biscuit
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Metabolic Regulation, Fasting
Effects of Dietary Manipulation on Metabolism in Healthy Adults
This study will examine the potential changes in the blood levels of a recently discovered metabolic regulator in response to changes in diet in healthy adults.
- Conditions
- Metabolic Regulation, Fasting, Ketogenic Diet
- Trial name
- NCT00476125
- Testing
- Dietary manipulation ketogenic diet, Dietary Manipulation - 12 day ketogenic diet, 16 Hour Fast
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center