Clinical trials: Metabolic Regulation
Appetite Regulation
The Effects of Rye Crisp Bread on Appetite and Metabolic Function
The aim of this study is to contribute to a better understanding of how dietary fibre in rye affects appetite and metabolic processes.
- Trial name
- S2RBAM (NCT02011217)
- Testing
- Rye crisp bread A, Rye crisp bread B, Wheat crisp bread C
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Swedish University of Agricultural Sciences
Obesity
Insulin Regulation of Lipolysis and Lipolysis Proteins
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which…
- Trial name
- NCT03866408
- Testing
- Immediate weight loss, Pioglitazone, Deferred weight loss
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Underweight
Experimental Approach to Test Predictions of Body Weight Regulation Models
The regulation of human body weight and fatness is not fully understood. Although some models of regulation have been proposed (set point, dual-intervention point, others), no studies have been designed to test their predictions.
- Trial name
- DIP (NCT06309576)
- Testing
- Fasting-refeeding cycle
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Morbid Obesity
Energy Balance and Inflammation in Obese Adults Bariatric Surgery Follow-up
The prevalence of obesity is steadily growing in many parts of the world in order to reach epidemic proportions. Changes in signaling pathways state of hunger and satiety contribute to the increase in obesity and metabolic…
- Conditions
- Obesity, Morbid Obesity, Metabolic Syndrome, Inflammation
- Trial name
- NCT02101814
- Testing
- Roux-en-Y gastric bypass (bariatric surgery)
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Federal University of São Paulo
PreDiabetes
MINDD 3: Prediabetes and Delay Discounting
The proposed research will translate research on delay discounting to the prevention of Type 2 diabetes (T2D) in persons with prediabetes.
- Trial name
- MINDD (NCT03664726)
- Testing
- Episodic Future Thinking, Episodic Recent Thinking, Scarcity Narrative
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Leonard Epstein
Overweight and Obesity
Dairy Foods and Weight Loss
Obesity is a national epidemic with multiple causes and complex solutions. Research in both animals and humans has suggested that the inclusion of dairy foods into a moderate calorie restricted diet can increase weight loss and…
- Trial name
- NCT00858312
- Testing
- high dairy diet, Low Dairy
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Dehydration, Diabetes Mellitus, Type 2
INDIGO-2: The Effect of High Water Intake on Glucose Regulation in Low-drinkers
Previous studies have indicated increased vasopressin due to hypertonic saline infusion impairs glucose regulation. The current study will examine the effect of low water intake on glucose regulation.
- Trial name
- INDIGO-2 (NCT04076995)
- Testing
- Water Intake
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Obesity & Overweight, Appetite Regulation
Colonic Delivery of DIM and Perilla Oil on Gut Hormones and Food Intake in Obesity
The goal of this clinical trial is to learn whether targeted food supplement capsules that release nutrients in the lower gut can increase appetite-regulating gut hormones and reduce food intake in adults with obesity.
- Trial name
- NCT07448519
- Testing
- Colonic-delivered DIM + Perilla oil
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Queen Mary University of London
PreDiabetes, Impaired Glucose Tolerance
Almonds and Health Effects on Metabolism, Vascular Function and Cognition
The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and Obesity
- Trial name
- NCT03419702
- Testing
- Almonds
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Maastricht University Medical Center
Obesity
Role of Sweetness in Glucose Regulation
Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of…
- Trial name
- STS (NCT03844230)
- Testing
- Control - Inhibition, Experimental I- Inhibition, Experimental II- Inhibition
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Insulin Resistance, Type 2 Diabetes Mellitus
T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
The purpose of this research study is to understand the effects of testosterone and estrogen on the body's response to the hormone insulin.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency
- Trial name
- T-IR (NCT01686828)
- Testing
- Acyline, Testosterone 1.62% gel, Letrozole
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Disorder of Glucose Regulation
SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition
We investigate the impact of taste receptors (sweet, bitter and umami) on human metabolism. There ist growing evidence, that components of the taste signalling system, including the taste receptor proteins , have important…
- Trial name
- SEGATROM (NCT02219295)
- Testing
- sweet block, bitter block, umami-block
- Where
- Germany
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
IBD
Regulation of Vitamin D Metabolism by Washed Microbiota Transplantation in Patients With IBD
WMT could effectively induce clinical response and maintain remission in patients with Inflammatory bowel disease (IBD). VD maintains gut microbiota and gut microbiota alter intestinal vitamin D metabolism (VDM),The aim of this…
- Trial name
- NCT04989374
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Obesity, Depression
Engaging Self-regulation Targets to Improve Mood and Weight and Understand Mechanism in Depressed and Obese Adults
Multimorbidity (i.e., the coexistence of 2 or more chronic conditions in an individual) is increasingly recognized as a pressing public health problem.
- Trial name
- NCT03841682
- Testing
- I-CARE2
- Where
- 2 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Diabetes Mellitus, Type 2
Pioglitazone Incretin Study
Incretin hormones are hormones produced by the gut in response to food intake. These hormones help the body to control the metabolism of glucose (sugar).
- Trial name
- NCT00656864
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Vermont
Obesity, Diabetes
Endocrine Regulation of Lipolysis in Obesity and Diabetes
Adipose tissue (AT) dysfunction is a commonly observed feature of metabolic dysfunction in obesity and diabetes. An important characteristic when examining AT function is the capacity to break down stored lipids (i.e.
- Trial name
- ERLO (NCT02598544)
- Testing
- adipose tissue sampling
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Obesity
Regulation of Muscle Protein Phenotype in Humans With Obesity
A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcomes.
- Trial name
- NCT04700800
- Testing
- Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Morbid
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss.
- Trial name
- NCT03868592
- Testing
- Gastric sleeve/bariatric surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Type 2 Diabetes, Insulin Requiring
The Effect of Ethanol on Overnight Glucose Regulation in Type 2
Hypoglycemia is the principal barrier to the achievement of target glycemic goals in type 2 diabetes. Alcohol consumption is very prevalent in our society and a proven cause of hypoglycemia.
- Trial name
- NCT00566592
- Testing
- oral ethanol, overnight, IV ethanol, soda water
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hyponatremia
Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges
Hyponatremia is the most common electrolyte disorder of all and can be observed in more than 30% of all patients in hospitals. Osmotic homeostasis of body fluids is essential for survival of all living creatures.
- Trial name
- RESERVE (NCT06408077)
- Testing
- Water administration, NaCl-Administration
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne