Clinical trials: Metabolic Regulation
PreDiabetes, Obesity
Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
Purpose of the Study: This study is to learn more about how exercising at different times of the day (morning versus evening) affects metabolism of glucose in the body, sleep, activity outside of exercise, and other factors.
- Conditions
- PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
- Trial name
- TExIS (NCT06292000)
- Testing
- AM Exercise, PM Exercise
- Where
- United States
- Sponsor
- University of Colorado, Denver
Obesity, Women
Probiotics' Effects on Hormones, Body and Mood in Obese Women
To evaluate the regulatory effect of probiotics formula on visceral fat metabolism and sex hormone balance in obese women.
- Trial name
- NCT07013409
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Childhood Obesity
Physical Activity and Screen-Time Regulations in Childcare Centers - Aim 2
Objective is to examine the physical activity and screen-time behaviors of children enrolled in licensed childcare centers before and after the enactment of new state regulations.
- Trial name
- Pause and Play (NCT02751814)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
Learning Theory to Improve Obesity Treatment
The purpose of this study is to optimize an obesity treatment program targeting overweight 8-12 year old children using "Cue Exposure Training".
- Trial name
- iROC (NCT01708785)
- Testing
- Single food Cue Exposure Treatment, Multiple food Cue Exposure Treatment, Partial Reinforcement - Enhanced Cue Exposure Treatment
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Gestational Diabetes, Insulin Resistance
Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development
This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3, 5 and 10-12 year after delivery.
- Conditions
- Gestational Diabetes, Insulin Resistance, Obesity Prevention
- Trial name
- GEN3G (NCT01623934)
- Where
- Canada
- Volunteers
- 1,034 people
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes Mellitus
Comparison of Metformin and Pioglitazone Effects on Adipokines Concentrations in Newly Diagnosed Type 2 Diabetes Patients
Oral hypoglycemic agents encompass the mainstay of treatment in the majority of patients with type 2 diabetes. Thiazolidinediones (such a pioglitazone) and Biguanides (such as metformin), are two major groups of hypoglycemic…
- Trial name
- NCT01593371
- Testing
- Metformin, Pioglitazone
- Where
- Iran
- Volunteers
- 98 people
- Sponsor
- Tehran University of Medical Sciences
Insulin Sensitivity, Healthy Adult
Diaplex and Glycemic Control
The goal of this 16-week double-blind, placebo-controlled pilot study is to determine whether daily Diaplex supplementation improves insulin sensitivity and glycemic control in adults with elevated blood glucose levels, while…
- Trial name
- NCT07711587
- Testing
- Diaplex
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
Muscle Weakness, Muscle Loss
A Study on the Effects on Glucose Regulation, Inflammation and Serum Lipids After Fish Protein Supplementation in Elderly (GRIPE)
The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population.
- Conditions
- Muscle Weakness, Muscle Loss, Blood Sugar; High, Inflammation
- Trial name
- GRIPE (NCT03529344)
- Testing
- Blue whiting protein hydrolysate
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
A diagnosis of gestational diabetes mellitus (GDM)has significant implications for the future health of the mother. GDM is often the culmination of years of unrecognized and unmodified diabetes risk factors that lead to overt and…
- Conditions
- Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT01234649
- Testing
- Metformin XR plus liraglutide
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Woman's
Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease
Effects of VLCKD in Metabolic Syndrome
VLCKD has showed to be an impactful diet on several metabolism aspects and has proven to be useful for preventing and treating diabetes mellitus type 2, overweight, chronic inflammation and fatty liver.
- Conditions
- Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Obesity, Metabolic Syndrome
- Trial name
- KETO-MI (NCT05275608)
- Testing
- VLCKD diet with replacing meals, Hypocaloric mediterranean Diet
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Insulin Resistance
Regulation of Endogenous Glucose Production by Brain Insulin Action in Insulin Resistance
It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production.
- Trial name
- NI EGP highBMI (NCT03383822)
- Testing
- Intranasal insulin
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Obesity
The Energy Balance Study
Very low carbohydrate diets and high-complex carbohydrate, low-fat diets are popular weight-loss methods in the United States. The purpose of the Energy Balance Study is to explore how extreme differences in diet affect eating…
- Trial name
- EBS (NCT01029483)
- Testing
- Low carbohydrate diet, High-carbohydrate ad libitum intervention, High carbohydrate diet-energy matched intervention
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Insulin Resistance, Diabetes
Regulation of Endogenous Glucose Production by Brain Insulin Action
It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production.
- Trial name
- Nasal insulin (NCT02131948)
- Testing
- Intranasal insulin
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Executive Function Disorder, Emotional Regulation
Evaluation of Executive Function and Emotional Regulation in Children in Bangladesh
The study explores the impact of malnutrition at enrollment on executive function (EF) and emotional regulation (ER) in malnourished 1-year-old children and whether specially designed brain directed therapeutic feeds improve…
- Conditions
- Executive Function Disorder, Emotional Regulation, Malnutrition, Child
- Trial name
- NCT05629624
- Testing
- Chickpea based RUSF, E-RUSF, Outcome reference group/RUSF
- Where
- Bangladesh
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Obesity, Sleep
Effects of Impaired Sleep on Energy Balance
The main aim of this study is to examine the effects of restricted sleep on energy and substrate metabolism as well as relevant hormonal systems that might be involved in the underlying mechanisms.
- Trial name
- SLOPUS (NCT01198431)
- Testing
- Sleep duration
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Vitamin D Deficiency, Immunosuppression
Helminth Infection During Pregnancy on Vitamin D Regulation: HELMVIT Study
Purpose: To examine whether helminth infection during pregnancy alters Vitamin-D-metabolism and reactivity of the child's immune system Hypothesis: Helminth infection during pregnancy is associated with altered Vitamin D levels…
- Trial name
- HELMVIT (NCT04324853)
- Testing
- Microscopy ( Urine filtration), UCAA test, qPCR,, Microscopy (Kato Katz, Coproculture, Harada Mori, MIF), qPCR,
- Where
- Gabon
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Gestational Diabetes Mellitus, Gestational Diabetes Mellitus in Pregnancy
Prenatal Exercise and Glucose Regulation
Gestational diabetes mellitus (GDM) is the most common disease during pregnancy and is characterized by an inability to regulate blood glucose (sugar) levels because of resistance to the hormone, insulin, which is responsible for…
- Conditions
- Gestational Diabetes Mellitus, Gestational Diabetes Mellitus in Pregnancy, Insulin Resistance
- Trial name
- FITT-B (NCT07802262)
- Testing
- Acute exercises sessions with different exercise types and intensities
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Central Arkansas
Atherosclerosis
Effects of PA-1 Transcriptional Regulation on Monocyte Function
Researching genetic differences in people with no prior medical conditions for better understanding of cardiac diseases through genetic research.
- Trial name
- NCT00512369
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Bariatric Surgery, Obesity
Endocrinological and Neuronal Aspects of Bariatric Surgery
The overall aim of the proposed project is to investigate the contribution of changes in neuronal food processing, hypothalamic reactivity and hormonal factors to weight loss after bariatric surgery.
- Trial name
- BACEN (NCT04634929)
- Testing
- bariatric surgery, conservative diet
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Heidelberg Medical Center
Obesity, Metabolic Disease
mTORC1 and Autophagy in Human Brown Adipocytes
The long term goal is to identify the potential therapeutic targets for the treatment of obesity and its associated disorders by studying the driving factors of activation of brown adipose tissue (BAT) in human adults.
- Trial name
- mTORHBFC (NCT04206124)
- Testing
- Brown Fat Harvest During Anterior Neck Surgery
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of New Mexico