Clinical trials: Metabolic Regulation
Obesity, Emotional Eating
Evaluation of Anhedonia and Emotional Eating in Individuals Using GLP-1 Receptor Agonists
This prospective observational study evaluates the longitudinal changes in anhedonia levels and emotional eating behaviors among adult individuals initiating glucagon-like peptide-1 (GLP-1) receptor agonist therapy for weight…
- Conditions
- Obesity, Emotional Eating, Anhedonia
- Trial name
- NCT07803185
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Gestational Diabetes, Pregnancy Related
Glycemic Observation and Metabolic Outcomes in Mothers and Offspring
The overarching goal of Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs) is to perform a comprehensive, longitudinal description of maternal glycemia over the course of pregnancy and to evaluate how…
- Trial name
- GO MOMs (NCT04860336)
- Testing
- Observational
- Where
- 9 sites in United States
- Volunteers
- 2,179 people
- Sponsor
- Northwestern University
Obesity, Overweight
The Influence of Acute Moderate-intensity Continuous Exercise on Appetite Regulation
A key area of obesity research has focused on the link between appetite, energy balance and weight control. Within this area, several appetite-related hormones and cellular cytokines have been identified as key signals…
- Trial name
- NCT06296511
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Coronary Artery Disease, Acute Coronary Syndrome
PAR Regulation of Platelet Function in Diabetic Patients
Thrombin is the most potent activator of platelets, and platelet activation is a hallmark of thrombosis. Coronary artery disease (CAD) is the major cause of mortality and morbidity in the United States and other industrialized…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Diabetes, Metabolic Syndrome
- Trial name
- NCT00855374
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Type 2 Diabetes, Cardiometabolic Syndrome
PDE3B in Metabolic Regulation
Phosphodiesterase 3B (PDE3B), an enzyme responsible for the degradation of cyclic AMP and GMP (two important second messengers used for intracellular signal transduction), has been associated with cardiometabolic outcomes.
- Conditions
- Type 2 Diabetes, Cardiometabolic Syndrome, Cardiovascular Diseases
- Trial name
- NCT06533007
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Sleep Disturbance, Fatigue Syndrome, Chronic
Bao Yuan Tang Extract and Galactooligosaccharides for Sleep Regulation
Certain classical formulas in traditional Chinese medicine and dietary prebiotics have demonstrated beneficial effects on various aspects of suboptimal health status in previous studies.
- Conditions
- Sleep Disturbance, Fatigue Syndrome, Chronic, Endocrine Disorder, Glucose Metabolism Disorder
- Trial name
- NCT07774897
- Testing
- Combination product (Bao Yuan Tang full-component extract 2.0g and galactooligosaccharides 2.0g), Galactooligosaccharides 2.0g
- Where
- 6 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Impaired Glucose Tolerance
Mechanisms Underlying the Regulation of Impaired Glucose Tolerance by Auricular Concha Electro-acupuncture
Impaired Glucose Tolerance (IGT) is an abnormal metabolic state following glucose metabolic steady state but prior to diabetes. IGT is an important stage during the progression of diabetes, with an underlying mechanism of insulin…
- Trial name
- NCT03343262
- Testing
- ta-VNS, Electro-acupuncture
- Volunteers
- 158 people
- Sponsor
- China Academy of Chinese Medical Sciences
Obesity
Impact of High Fiber Snacks on Adiposity, Glucose Regulation and Appetite
The primary objective of the proposed research is to determine the influence of 8 weeks of twice daily consumption of 120 kcal servings of dried apples or a commonly consumed low fat 120kcal muffin on components of obesity (waist…
- Trial name
- NCT02217124
- Testing
- dried apples, muffin
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Overweight, Obesity
Effect of Consuming Beans for One Month on Blood Lipids, Satiety, Intake Regulation and Body Weight
This project investigates the effect of regular consumption of commercially available processed white beans (5 cups per week) on food intake, body weight, blood pressure, satiety hormones and glycemic response over a 4-week…
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00741923
- Testing
- navy beans added to regular diet
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Toronto
Obesity
Energy Balance Weight Regulation Study
The purpose of this study is to test the hypothesis that a low-carbohydrate diet will impact hormones and other factors that regulate appetite and energy balance, and result in lower energy intake and greater weight loss, than a…
- Trial name
- BALANCE (NCT00619008)
- Testing
- Ad libitum low carbohydrate diet, Ad libitum High Complex Carbohydrate Diet, Energy-restricted high complex carbohydrate diet
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Obesity, Weight Gain
Exercise, Brain Activity, and Weight Maintenance
This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
- Conditions
- Obesity, Weight Gain, Bariatric Surgery Candidate, Appetitive Behavior
- Trial name
- NCT06511310
- Testing
- Exercise
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Insulin Resistance, Type2 Diabetes Mellitus
High-fat Overfeeding, Hepatokines and Appetite Regulation
The present study will investigate the effect of high-fat overfeeding on a group of liver-secreted proteins linked to worsened blood sugar control, as well as proteins involved in appetite control.
- Conditions
- Insulin Resistance, Type2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity
- Trial name
- OVEREAT (NCT03369145)
- Testing
- High-fat diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Type 2 Diabetes Mellitus, Obesity
DECREASE: Dapagliflozin Plus Exenatide on Central REgulation of Appetite in diabeteS typE 2
This is a 16 week, phase 4, randomized and placebo controlled trial, investigating the separate and combined effects of Sodium Glucose coTransporter 2 (SGLT2) inhibition with dapagliflozin and Glucagon Like peptide-1 (GLP-1)…
- Trial name
- DECREASE (NCT03361098)
- Testing
- Dapagliflozin 10mg, Exenatide
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Amsterdam UMC, location VUmc
Binge-Eating Disorder, Obesity
Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity
BACKGROUND: Binge eating disorder (BED) is the worldwide most-prevalent eating disorder. It is associated with psychiatric comorbidities and obesity, a high impact in life functioning, and high morbidity and mortality.
- Conditions
- Binge-Eating Disorder, Obesity, Eating Disorders, BED
- Trial name
- PREC-BED (NCT06387719)
- Testing
- Magnetic resonance imaging
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Fundació Sant Joan de Déu
Obesity
Insulin Regulation of Lipolysis and Lipolysis Proteins
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which…
- Trial name
- NCT03866408
- Testing
- Immediate weight loss, Pioglitazone, Deferred weight loss
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Weight Loss, Weight Gain Prevention
Improving Appetite Regulation in Patients With Obesity
Over 70% of U.S. adults have overweight or obesity. Currently, the most efficacious behavioral intervention for obesity is standard behavioral treatment (SBT), often composed of group sessions, calorie goals, and physical…
- Conditions
- Weight Loss, Weight Gain Prevention, Obesity
- Trial name
- NCT05200520
- Testing
- Appetite Self-Regulation Intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Multiple Sclerosis
Regulation of Lipid Metabolism in Autoimmune Disease: Multiple Sclerosis
The aim of this research is to understand how lipids such as cholesterol affect the disease process in people with MS.
- Trial name
- RELOAD-MS (NCT04053374)
- Testing
- Blood sampling
- Where
- 2 sites in United Kingdom
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University College, London
Aging, Glucose Intolerance
Regulation of B-Cell Function & Glucose Tolerance in Older People
This VA CDA-2 proposal will test in detail if lifestyle intervention with aerobic exercise training improves the body's production of insulin in older people at risk to develop diabetes.
- Trial name
- NCT00554112
- Testing
- Exercise
- Volunteers
- 90 people
- Sponsor
- US Department of Veterans Affairs
Lipodystrophy, Dunnigan Syndrome
Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's Lipodystrophy
The objective of this work is to identify biomarkers of interest in patients with insulin resistance leading to early disorders of glycemic regulation.
- Trial name
- IRAP-DUN 2 (NCT05424913)
- Testing
- research-specific blood sample
- Where
- Reunion
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Glycemic Control, Satiety Response
Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein
The proposed study aims to simulate a meal eaten at home, where meals will provide a fixed amount of protein from beef or vegetarian substitute "meat" balls with ad libitum access to one of mashed potatoes, full-fat fries, or…
- Conditions
- Glycemic Control, Satiety Response, Appetite Regulation, Diabetes
- Trial name
- NCT05610124
- Testing
- Ad libitum full-fat French fries with beef meatballs, Ad libitum instant mashed potatoes with beef meatballs, Ad libitum macaroni pasta with beef meatballs
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto