Clinical trials: Metabolic Regulation
Metabolic Syndrome X, Type 2 Diabetes Mellitus
Effect of Fish Oil on Insulin Sensitivity
The purpose of this study is to determine whether a prolonged (9 month) high (6g/d) of marine oil improves insulin sensitivity and glucose control in subjects with impaired glucose regulation.
- Conditions
- Metabolic Syndrome X, Type 2 Diabetes Mellitus, Sarcopenia
- Trial name
- NCT01241474
- Testing
- EPAX 6000 (marine omega 3 EPA/DHA fatty acid concentrates, Maize (corn) oil
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Aberdeen
Appetite Regulation, Obesity
Effect of Oligofructose on Appetite in Overweight Subjects
This study seeks to look into the effects of oligofructose supplementation on appetite, energy intake, and body weight and body composition in overweight subjects.
- Trial name
- NCT00912197
- Testing
- Oligofructose
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Polycystic Ovary Syndrome
Development of a Structured Education Programme for Women With Polycystic Ovary Syndrome
Polycystic Ovary syndrome (PCOS) is a common hormonal imbalance affecting about 12% of women in the UK. The number of women with PCOS is rising.
- Trial name
- SUCCESS (NCT01462864)
- Testing
- Structured Lifestyle Education
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- University of Leicester
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Stroke, Hyperglycemia
Glucose Regulation in Acute Stroke Patients (GRASP) Study
The purpose of this study is to assess the feasibility, safety and preliminary efficacy of the use of insulin infusions as treatment for hyperglycemic acute ischemic stroke patients.
- Trial name
- NCT00282867
- Testing
- IV glucose insulin and potassium, GIK, standard care
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of Virginia
Childhood Obesity
Efficacy of ENTREN-F Program: A Psycho-family Intervention in Childhood Obesity
ENTREN-F Programme describes a novel structured psychosocial family-based intervention from Primary Care using a train trip metaphor aimed at improving healthy lifestyles for the whole family.
- Trial name
- ENTREN-OB (NCT04465799)
- Testing
- ENTREN, ENTREN-F, Control group
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Universidad Autonoma de Madrid
Prediabetic State
Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects
Branching chain amino acids (BCAA) have both beneficial and detrimental effects of on metabolism have been established and therefore warrants further investigation.
- Trial name
- BCAA (NCT02684565)
- Testing
- BCAA High Protein supplement, BCAA Low Protein supplement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Obesity, Menopausal Syndrome
Regulation of Cortisol Metabolism and Fat Patterning
The purpose of this study is to determine if estrogen or testosterone can affect cortisol levels and where fat builds up in our bodies.
- Trial name
- NCT00694733
- Testing
- Depo Lupron/Aromatase inhibitor, Estrogen cream
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Spinal Cord Injuries, Type 2 Diabetes
Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes
It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition.
- Trial name
- NCT06706284
- Testing
- Semaglutide Injectable Product
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Marzieh Salehi
Dietary Prevention
Effects of Legumes on Glucose Regulation
Dietary prevention strategies are increasingly recognized as essential to combat the current epidemic of obesity and related metabolic disorders.
- Trial name
- NCT01706042
- Testing
- legume meal, white bread
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lund University
Overweight and Obese Adults, High Intensity Interval Exercise (HIIE)
Acute Effects of Isoenergetic HIIE vs. MICE on Key Parameters of Fat Mass Loss in Young Females With Overweight or Obesity
Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases.
- Trial name
- COMEFIT (NCT06868862)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Overweight
Identifying the Effect and Working Mechanisms of MyPlan 2.0 in Older Adults
The aim of this study is to investigate whether and how 'MyPlan 2.0' helps older adults to be more physically active or less sedentary. Two groups will be created, an intervention group and a waiting-list control group.
- Trial name
- NCT03799146
- Testing
- MyPlan 2.0, Waiting List
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Ghent
Health, Appetite Regulation
Sodium Alginate in Chocolate Milk, Satiety and Glycemic Control
This study compares the effects of isovolumetric (325 ml) preloads of chocolate milk supplemented with sodium alginates at incremental doses on inter-meal glucose levels, appetite scores and food intake in healthy adult men.
- Conditions
- Health, Appetite Regulation, Glucose Metabolism
- Trial name
- NCT01877460
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Insulin Resistance Syndrome
Diagnostic Interest of the IRAP Protein (Insulin Regulated Amino Peptidase) in Insulin Resistance
There is currently no reliable, diagnostic tests of insulin resistance other than the hyperinsulinemic euglycemic clamp which, due to its constraints and cost, is reserved for research.
- Trial name
- IRAP-IR (NCT04028895)
- Testing
- Dosage of IRAP during OGTT
- Where
- 4 sites in France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy, Overweight (BMI > 25)
Effect of Probiotics on Appetite Regulation in Adults With Overweight/Obesity
The goal of this 16-week randomised, placebo-controlled parallel study is to investigate the effect of a newly formed probiotic supplement on satiety and gut microbiota composition in healthy men and women with overweight or…
- Conditions
- Healthy, Overweight (BMI > 25), Overweight , Obesity, Male
- Trial name
- ProBiSat (NCT07715955)
- Testing
- Probiotic supplementation
- Where
- Netherlands
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Overweight
Effects of Meal Energy Density on Body Measures and Metabolism in Women
This study investigates whether the timing of energy intake during the day-specifically consuming more calories at breakfast or at dinner-affects body measurements, blood sugar levels, cholesterol, and feelings of hunger in women…
- Conditions
- Obesity, Overweight, Appetite Regulation, Meal Timing
- Trial name
- NCT07066618
- Testing
- Breakfast-Loaded Hypocaloric Diet, Dinner-Loaded Hypocaloric Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Melike Nur Eroğlu
Schizophrenia, Type 2 Diabetes Mellitus
Janssen - Glucose Regulation/Risp/Olanz
Abnormalities in peripheral glucose regulation and type 2 diabetes can occur more commonly in individuals with schizophrenia than in healthy subjects or in other psychiatric conditions.
- Trial name
- NCT00205738
- Testing
- Risperidone, Olanzapine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes
Walking Away: Structured Education Versus Written Information for Individuals With High Risk of Developing Type 2 Diabetes
Diabetes is a debilitating chronic disease reaching epidemic proportions. Lack of physical activity is a key factor driving this epidemic and it is therefore vital that workable methods of encouraging people to exercise and…
- Trial name
- NCT00941954
- Testing
- Structured Education, Written Information
- Where
- United Kingdom
- Volunteers
- 833 people
- Sponsor
- University Hospitals, Leicester
Diabetes, Obesity
Role of Methane in Glycemic Control
The purpose of this study is to determine how certain types of bacteria in the human gut may affect weight gain, and contribute to the development of diabetes.
- Trial name
- NCT01638429
- Testing
- Neomycin, Rifaximin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Obesity
What is the Maximum Amount of Carbohydrates That is Still Able to Induce Ketosis and Suppress Appetite?
Two dietary approaches, very low energy diets (VLEDs) and ketogenic low carbohydrate diets (KLCDs), have the ability to suppress appetite.
- Trial name
- NCT02944253
- Testing
- Low energy diet 70 gram carbohydrates, Low energy diet 100 gram carbohydrates, Low energy diet 130 gram carbohydrates
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology