Clinical trials: Metabolic Regulation
Type 2 Diabetes
High-amylose Barley (HIAMBA) in the Regulation and Prevention of Type 2 Diabetes
In a series of double-blinded randomized cross-over acute studies, the investigators want to study the effects of naturally produced high-amylose barley (Lean-baking barley®) on the postprandial glucose-metabolism in subjects…
- Trial name
- NCT04702672
- Testing
- 100% wheat (control), 100% Lean-baking barley®, 100% regular barley
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetes
Diabetes Management Personal Trainer
This 1-year study will test the feasibility and effectiveness of a diabetes personal trainer in helping youth with diabetes manage their treatment.
- Trial name
- NCT00340093
- Testing
- Managing Diabetes
- Where
- 2 sites in United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Appetite Regulation, Energy Intake
Impact of Sourdough Bread Consumption on Long-term Energy Intake: A Pilot Study of Feasibility
The present study is a pilot study examining whether long-term sourdough bread consumption reduces energy intake and blood lipids levels over a period of 4 weeks in free-living normalweight and overweight participants.
- Conditions
- Appetite Regulation, Energy Intake, Body Weight Changes, Eating Behavior
- Trial name
- SOBER (NCT05590611)
- Testing
- Dietary Intervention with Brown Bread, Dietary Intervention with Sourdough Bread
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Obesity, Abdominal, Feeding Patterns
Circadian Rhythms in Human Adipose
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
- Trial name
- NCT06891534
- Testing
- Continuous Feeding, Intermittent feeding
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes Mellitus
Comparison of Metformin and Pioglitazone Effects on Adipokines Concentrations in Newly Diagnosed Type 2 Diabetes Patients
Oral hypoglycemic agents encompass the mainstay of treatment in the majority of patients with type 2 diabetes. Thiazolidinediones (such a pioglitazone) and Biguanides (such as metformin), are two major groups of hypoglycemic…
- Trial name
- NCT01593371
- Testing
- Metformin, Pioglitazone
- Where
- Iran
- Volunteers
- 98 people
- Sponsor
- Tehran University of Medical Sciences
Ketosis, Regulation of Muscle Protein Synthesis
Ketones and Muscle Protein Synthesis
Ketones are natural substances normally produced by the body during prolonged fasting and starvation, or in response to a "ketogenic" diet to be used as fuel by the brain and muscles.
- Trial name
- NCT04565444
- Testing
- Ketone, Ketone + Protein, Protein
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McGill University
Overweight and Obesity
Dairy Foods and Weight Loss
Obesity is a national epidemic with multiple causes and complex solutions. Research in both animals and humans has suggested that the inclusion of dairy foods into a moderate calorie restricted diet can increase weight loss and…
- Trial name
- NCT00858312
- Testing
- high dairy diet, Low Dairy
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Insulin Resistance
Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome
Sirtuin activators may prove useful in treating age-related diseases and extending lifespan in humans. Resveratrol (RSV), a polyphenol found in red wine, has been shown in vitro to enhance SIRT1 activity.
- Trial name
- RSV (NCT00654667)
- Testing
- Resveratrol
- Where
- United States
- Sponsor
- University of California, San Francisco
Overweight Adolescents, Obese Adolescents
Pilot Testing a Novel Approach to Pediatric Obesity Treatment
The goal of this clinical trial is to learn if an emotion regulation and self-monitoring intervention can help treat overweight and obesity in teens.
- Trial name
- NCT06755827
- Testing
- Emotion regulation and self-monitoring to treat pediatric obesity, Psychoeducation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Texas Tech University
Prader-Willi Syndrome
Effects of Transcutaneous Vagus Nerve Stimulation on Emotion Regulation and Executive Functioning in Prader-Willi Syndrome
The STIM-PRADER study aims to assess the effectiveness of auricular vagal neuromodulation therapy (aVNT) on emotional, behavioral, and cognitive domains impaired in Prader-Willi Syndrome (PWS).
- Trial name
- STIM-PRADER (NCT06720571)
- Testing
- Auricular vagal neuromodulation therapy (aVNT)
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University of Bordeaux
Childhood Obesity
Physical Activity and Screen-Time Regulations in Childcare Centers - Aim 2
Objective is to examine the physical activity and screen-time behaviors of children enrolled in licensed childcare centers before and after the enactment of new state regulations.
- Trial name
- Pause and Play (NCT02751814)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Physiological Effect of TCC on Glucose Metabolism
Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function
The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners.
- Trial name
- NCT03503084
- Testing
- Classical Yang's TCC exercise
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Physical Inactivity, Walking
Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife
The purpose of this study is to determine whether interaction with an adaptive Fitbit-based goal setting application can increase levels of everyday light intensity physical activity in middle-aged adults.
- Conditions
- Physical Inactivity, Walking, Cognitive Health, Self-regulation
- Trial name
- NCT05826379
- Testing
- Adaptive Daily Goal Setting, Interim Goal Prompt
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Healthy Volunteers
Finasteride, Dutasteride and Insulin Action
The purpose of this study is to see if an enzyme in the body (5-alpha reductase, 5αR) is important in controlling how the body handles sugar and fat.
- Trial name
- FIND-IT (NCT01923090)
- Testing
- Finasteride, Dutasteride
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Obesity
CHRONOtype-adjusted DIET on Weight Loss
BACKGROUND: Several reports have observed that the alteration of normal biological rhythms is associated with obesity development.
- Trial name
- CHRONO-DIET (NCT03755674)
- Testing
- CHRONOTYPE-ADJUSTED DIET
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Type 1 Diabetes Mellitus, Sleep
Sleep and Glucose Regulation in Youth With Type 1 Diabetes Mellitus
The purpose of this project is to look at how sleep affects glucose values in children with Type 1 Diabetes Mellitus. It will also evaluate if glucose is affected by times of day due to the body's own internal rhythm also known…
- Trial name
- NCT00848822
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Osteopenia, Osteoporosis
Isoflavone Treatment for Postmenopausal Osteopenia.
The aim of the project is to execute a double-blind, parallel, randomized 12-month intervention trial on postmenopausal women with osteopenia (low bone mineral density), in order to determine the effects of daily intake of…
- Trial name
- NCT02174666
- Testing
- Red clover extract
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- University of Aarhus
Obesity, Sarcopenia
Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle
Obesity in humans has been shown to result in the increased release of small inflammatory-inducing proteins, called cytokines, from the fat cells of the body.
- Trial name
- NCT02305069
- Testing
- Pioglitazone, Insulin, Octreotide
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 1 Diabetes Mellitus
Efficacy of the "Living With Type 1 Diabetes to Grown-Up" Interactive Podcast Program
The present study aims to evaluate the intervention effectiveness of the Online Interactive Podcast Program"Living with Type 1 Diabetes to Grown-Up"in patients with type 1 diabetes transitioning from adolescence to early…
- Trial name
- NCT06464640
- Testing
- Online Interactive Podcast Program "Living with Type 1 Diabetes to Grown-Up", E-book
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- Chang Gung University
Diabetes, Exercise
Differential Regulation of miRNA and Protein in Human Plasma Extracellular Vesicles by Different Types of Exercise.
Aims/hypothesis: Both continuous aerobic training (CAT) and high intensity interval training (HIIT) are recommended to promote health and prevent diseases.
- Conditions
- Diabetes, Exercise, Lifestyle Intervention
- Trial name
- NCT06609785
- Testing
- Exercise
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- West China Hospital