Clinical trials: Metabolic Risk Factors
Iron Overload
Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT
Hematopoietic Stem Cell Transplantation (HSCT) is currently a standard procedure for a wide range of blood-oncological diseases and genetic disorders.
- Trial name
- NCT04423237
- Testing
- Deferasirox
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- University of Pisa
Diabetes, Hypertension
Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD)
Diabetic kidney disease (DKD) is associated with high rates of cardiovascular events and death. In addition, DKD is the major cause of end-stage renal disease (ESRD) in the United States.
- Conditions
- Diabetes, Hypertension, Diabetic Kidney Disease
- Trial name
- STOP-DKD (NCT01829256)
- Testing
- Pharmacist telehealth intervention
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- Duke University
Atrophy
Effect of Exercise on Risk-factors of Elderly Women
The purpose of this study is to determine whether exercise training may impact relevant risk factors and health costs of community living women older 65 years.
- Trial name
- NCT00267839
- Testing
- physical exercise, wellness
- Where
- 2 sites in Germany
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Nutritional and Metabolic Diseases
Ratio of Dietary Calcium to Magnesium on Cardiovascular Risk
Although the epidemiological studies indicate how magnesium and calcium may interact to affect cardiovascular risk, current clinical trials have not elucidated the associations, particularly among hypertensive patients.
- Conditions
- Hypertension, Nutritional and Metabolic Diseases, Cardiovascular Risk Factor
- Trial name
- NCT04531267
- Testing
- Individualized dosage of calcium and magnesium
- Volunteers
- 42 people
- Sponsor
- Guangdong Provincial People's Hospital
Hypertension, Diabetes
Study of a Community Based Approach to Control Cardiovascular Risk Factors in India
The study is a 2 year community based cluster randomized controlled trial to assess the role that a community health worker led intervention, in concert with physician education, can play in controlling the principal…
- Conditions
- Hypertension, Diabetes, Smoking, Cardiovascular Diseases
- Trial name
- SEHAT (NCT02115711)
- Testing
- Community health worker
- Where
- India
- Volunteers
- 1,242 people
- Sponsor
- University Hospitals Cleveland Medical Center
Metabolic Syndrome
Risk Factors Related to Metabolic Syndrome in School-aged Children Who Were Born Preterm
This is a follow-up cohort study of 8 years old children born preterm at Seoul National University Children's Hospital in Korea from 2008-2009.
- Trial name
- NCT02746887
- Testing
- Preterm/term cohort
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Metabolic Syndrome, Insulin Resistance
High-intensity Interval, Low Volume Training in Metabolic Syndrome
The primary objective of the study is to compare the efficacy of an intervention with high-intensity interval, low volume training (HIIT-LV) or continuous aerobic exercise (CAE) on insulin resistance, insulin sensitivity and…
- Trial name
- Intraining-MET (NCT03087721)
- Testing
- HIIT-LV, CAE
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Peri-Implantitis, Type 2 Diabetes Mellitus
Surgical Treatment of Periimplantitis in Patients With Risk Factors
This study evaluates clinical and radiographic parameters among riks factor groups in patients with periimplantitis. This study will also treat and evaluate the patients response before and after surgical treatment.
- Conditions
- Peri-Implantitis, Type 2 Diabetes Mellitus, Smoking, Cigarette, Periodontal Diseases
- Trial name
- NCT03814434
- Testing
- Non-Surgical treatment, Surgical Treatment
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Luiz Antonio Pugliesi Alves de Lima
Cardiovascular Diseases, Cardiovascular Risk Factor
The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk
IPE-PREVENTION is a prospective, randomized, 3-month long, open-label study. A total of 70 individuals with elevated cardio-metabolic risk and heightened triglyceride levels, and who are on stable statin therapy will be…
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Triglycerides High, Diabetes Mellitus, Type 2
- Trial name
- IPE-PREVENTION (NCT04562467)
- Testing
- Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
- Where
- 3 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Overweight and Obesity, Type IIb Hyperlipidaemia
Low Carbohydrate Diet - Effect on Plasma Lipids and Metabolic Markers
Low carbohydrate diet may influence the plasma lipid levels.
- Conditions
- Overweight and Obesity, Type IIb Hyperlipidaemia, Hypercholesterolemia Aggravated
- Trial name
- NCT01476436
- Testing
- Low carbohydrate dietary advice, Continue usual diet
- Where
- 2 sites in Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cerebrovascular Accident, Stroke
Screening and Management of High-risk Populations of Stroke in Dehui City
This epidemiological survey is to analyze the prevalence rate of stroke and exposure rate of risk factors in sampling population aged 40 years and over (born before December 31,1975) in Dehui City, to provide scientific basis for…
- Conditions
- Cerebrovascular Accident, Stroke, Hypertension, Diabetes Mellitus
- Trial name
- SAMHPSDC (NCT05039034)
- Testing
- Advice according to primary prevention guidelines on stroke of China
- Where
- China
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- Yi Yang
Cardiovascular Diseases
Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary…
- Trial name
- HER-CROWN (NCT05632601)
- Testing
- PET scan
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Metabolic Dysfunction-Associated SteatoHepatitis (MASH)
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
This study is researching an investigational drug, ALN-HSD called "study drug". This study is focused on participants who are known to have Metabolic dysfunction-Associated SteatoHepatitis (MASH).
- Trial name
- NASHGEN-2 (NCT05519475)
- Testing
- ALN-HSD
- Where
- 71 sites in United States, Japan and 2 more
- Volunteers
- 120 people
- Sponsor
- Regeneron Pharmaceuticals
Cancer, Prevention Harmful Effects
Social Contextual Influences on Physical Activity
The goal of this study is to learn why some black and Latino men and women choose not to exercise very often. Researchers also want to learn more about any social and environmental factors that may affect the way an exercise…
- Trial name
- NCT01195337
- Testing
- PA Prescription Plan, Pedometer, Newsletters
- Where
- United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Femoral Neck Fractures, Pertrochanteric Fracture
Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures
The aim of this clinical trial is to compare serum concentration of bone intake proteins [ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)] and muscle atrophy marker [creatine kinase…
- Conditions
- Femoral Neck Fractures, Pertrochanteric Fracture, Bone Resorption, Bone Loss
- Trial name
- NCT05804604
- Testing
- Surgical treatment of proximal femur fracture and blood sample test, Blood sample test
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Bone Loss, Age-Related
Bone Fragility Study in Pediatric Population With Risk Factors
Low bone mass and osteoporosis are underdiagnosed in childhood in our environment and its prevalence is unknown. In most cases they are secondary to chronic diseases that conduct to a poor bone health condition and thereby a risk…
- Trial name
- NCT02751008
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Abdominal Obesity, Cardiac Disease
Effects of Different Dietary Interventions on Abdominal Fat Components, Quadriceps Muscles and Cardiometabolic Parameters
The study aims to evaluate the impact of different dietary interventions on body composition (abdominal fat components and quadriceps muscles) and cardiometabolic parameters.
- Conditions
- Abdominal Obesity, Cardiac Disease, Metabolic Disease, Cardiometabolic Syndrome
- Trial name
- NCT06320782
- Testing
- Calorie restriction and balanced distribution of macronutrients, Calorie restriction and low-carbohydrate diet, Calorie restriction and low-fat diet
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Type 2 Diabetes
Effect of Vildagliptin Versus Dapagliflozin as Add on Therapy to Metformin on Cardiovascular Risk Factors
The overarching hypothesis of this study is that vildagliptin (vilda) as add on therapy to metformin (met) in Egyptian type 2 diabetic obese patient will produce an equal, if not better, glycemic control and will reduce…
- Trial name
- NCT07077525
- Testing
- Dapagliflozin + Metformin, Vildagliptin + Metformin
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Al-Azhar University
Gestational Diabetes
Micronutrients in Pregnancy as a Risk Factor for Diabetes and Effects on Mother and Baby
There is a rapidly escalating epidemic of obesity and type 2 diabetes across the world, with the fastest rise occurring in low- and middle-income countries.
- Trial name
- PRiDE (NCT03008824)
- Where
- United Kingdom
- Volunteers
- 4,500 people
- Sponsor
- University of Warwick
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