Clinical trials: Metabolic Risk Factors
PreDiabetes
The Lifestyle Education About Prediabetes (Leap) Study
This research tested whether a standard version or very low-carbohydrate version of the Diabetes Prevention Program better improves outcomes like blood glucose control and body weight for patients with prediabetes.
- Trial name
- LEAP (NCT05235425)
- Testing
- Standard NDPP, Very low-carbohydrate diet
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Michigan
Type 2 Diabetes
Effects of Whole Fruit on Blood Sugar in People With Type 2 Diabetes
This study will determine the effects of consuming whole fruit on blood sugar control, liver fat, and cardiovascular health in adults with type 2 diabetes who are not treated with insulin.
- Trial name
- FRUIT2 (NCT07376226)
- Testing
- Whole Fruit
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Harvard School of Public Health (HSPH)
Metabolic Syndrome, Healthy Participants
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity.
- Conditions
- Metabolic Syndrome, Healthy Participants, Metabolically Healthy Obesity, Metabolically Abnormal Obesity
- Trial name
- NCT07095426
- Testing
- inulin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ball State University
Obesity, Abdominal, Metabolic Syndrome
Omega-3 PUFA in Prevention of Cardiovascular and Metabolic Diseases (CARDMET3)
The study is aimed to assess the efficacy of animal, plant sources of omega-3 polyunsaturated fatty acids and omega-3 pharmacological supplements on obesity, metabolic syndrome and cardiovascular disease.
- Conditions
- Obesity, Abdominal, Metabolic Syndrome, Cardiovascular Risk Factor
- Trial name
- CARDMET3 (NCT04208308)
- Testing
- Chia seeds supplementation (25 g), Chia seeds supplementation (15 g), Combine supplementation: chia seeds (15g) and fish oil Maxi Cor 70+20
- Where
- Slovakia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Pavol Jozef Safarik University
COVID-19, Cardiovascular Risk Factor
Predictors of Cardiovascular Risk in Covid-19 Patients During Acute Disease and at Short Term Follow-up
Northern Italy, and particularly Lombardy, is one of the regions of the world mostly affected by COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
- Trial name
- CARDICoVRISK (NCT04371289)
- Where
- Italy
- Volunteers
- 4,356 people
- Sponsor
- Istituto Auxologico Italiano
Obesity
Effect of a Unique Web-based Behaviour Change Program on Weight Loss and Cardiovascular Risk Factors
Web- or internet-based programs have the potential to induce and, possibly, help to sustain, significant lifestyle modification.
- Trial name
- NCT01472276
- Testing
- Web-based program
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Dipeptidyl-Peptidase 4 Inhibitors, LDL Cholesterol
Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes Trial
The purpose of this study is to determine whether Anagliptin or Sitagliptin are effective in reducing the low-density lipoprotein cholesterol in patients with type 2 diabetes and cardiovascular risk factors on statin.
- Conditions
- Dipeptidyl-Peptidase 4 Inhibitors, LDL Cholesterol, Glycosylated Hemoglobin, Diabetes Mellitus
- Trial name
- REASON (NCT02330406)
- Testing
- Anagliptin, Sitagliptin
- Where
- Japan
- Volunteers
- 353 people
- Sponsor
- Institute for Clinical Effectiveness, Japan
Metabolic Syndrome, Cardiovascular Risk Factor
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk
Metabolic Syndrome (MetS) and cardiovascular disease are associated with systemic inflammation (SI). Activation of the mechanisms of inflammation is triggered by the inflammatory cytokines.
- Trial name
- NCT04232852
- Testing
- Probiotic mix
- Where
- Greece
- Sponsor
- Attikon Hospital
Obesity, Hypertension
Improving Heart Health in Appalachia
Individuals in Appalachian Kentucky are vulnerable to cardiovascular disease (CVD) by virtue of having high rates of multiple CVD risk factors.
- Conditions
- Obesity, Hypertension, Hyperlipidemia, Depression
- Trial name
- HeartHealth (NCT01884246)
- Testing
- Self-care CVD risk reduction, Referral to primary care provider for CVD risk management
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Debra Moser
Microbiome, Metabolic Syndrome
Dietary Fibers Effect on the Gut Microbiota Composition
The randomized double-blinded placebo-controlled multicenter study will be held in parallel groups. During 5 weeks the efficacy of different endpoints as a measure of response to the daily intake of dietary fibers (8 g of either…
- Conditions
- Microbiome, Metabolic Syndrome, Cardiovascular Risk Factor, Inflammation
- Trial name
- NCT04114513
- Testing
- Maltodextrin, Inulin, Pectin
- Where
- Russia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Atlas Biomed
Gallstone
The Risk Factors of Symptomatic Gallbladder Stone: Age-Sex Matched Case-control Study Performed in Single Institute
The main purpose of this study is to investigate the region-specific cause of gallbladder stone incidence in Jeju Self-Governing Province, Korea.
- Trial name
- NCT02808546
- Volunteers
- 342 people
- Sponsor
- Cheju Halla General Hospital
Cardiovascular Diseases, Acute Myocardial Infarction
Biomarkers Predicting Acute Myocardial Infraction in Patients Without Standard Modifiable Risk Factors
Coronary heart disease (CHD) is the leading cause of mortality worldwide. Every year, millions of people suffer its most adverse manifestation, an acute myocardial infraction (AMI).
- Conditions
- Cardiovascular Diseases, Acute Myocardial Infarction, Acute Coronary Syndrome, Metabolic Disturbance
- Trial name
- BeyondSMuRFs (NCT05535582)
- Testing
- Investigation of clinical, laboratory and imaging profile
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- Aristotle University Of Thessaloniki
Obesity, Metabolic Syndrome
Exploring the Efficacy and Safety of Herbal Medicine on Korean Obese Women With or Without Metabolic Syndrome Risk Factors - A Study Protocol for a Double-blind, Randomised, Multi-center, Placebo-controlled Clinical Trial
The Purpose of this trial is to investigate the efficacy and safety of GGT on Korean obese Women with or without metabolic syndrome Risk factors
- Trial name
- NCT03479346
- Testing
- GGT
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Gachon University Gil Oriental Medical Hospital
Left Ventricular Dysfunction, Myocardial Infarction
St. Vincent's Screening To Prevent Heart Failure Study
The STOP-HF study is a prospective, randomized, controlled trial recruiting asymptomatic individuals with risk factors for left ventricular dysfunction from 50 primary care clinics in Dublin and south east Ireland.
- Conditions
- Left Ventricular Dysfunction, Myocardial Infarction, Hypertension, Diabetes
- Trial name
- STOP-HF (NCT00921960)
- Testing
- Intervention Care
- Where
- Ireland
- Volunteers
- 1,378 people
- Sponsor
- St Vincent's University Hospital, Ireland
Olanzapine, Breast Cancer
Olanzapine Based Dexamethasone-sparing Regimen for Breast Cancer Patients With Metabolic-risk Factors
The aim of THE STUDY to determine whether an olanzapine-based dexamethasone-sparing antiemetic regimen is non-inferior to the standard dexamethasone-containing regimen in preventing delayed-phase Chemotherapy-induced nausea and…
- Conditions
- Olanzapine, Breast Cancer, Dexamethasone
- Trial name
- NCT07743827
- Testing
- Pantoprazole, olanzapine, Dexamethasone
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Alexandria University
Obesity, Heart Diseases
The Effect of Xenical on Weight and Risk Factors
The purpose of this study is to determine the effect of using the weight loss medication Xenical (generic name - orlistat) on weight loss and change in heart disease risk factors in patients of the Healthy Heart Program Lipid…
- Trial name
- NCT00152360
- Testing
- Orlistat
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Type 2 Diabetes Mellitus
Women and Risk of Type 2 Diabetes
This is a follow-up survey of women, 10-12 years after they were included in the population-based Stork Groruddalen study of pregnant women, primarily set up to study gestational diabetes and related health issues in pregnancy in…
- Trial name
- NCT03870724
- Where
- Norway
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Weight Loss, Obesity
A Grapefruit Feeding Trial in Healthy, Overweight Adults
Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles.
- Conditions
- Weight Loss, Obesity, Cardiovascular Risk Factors
- Trial name
- NCT01452841
- Testing
- Grapefruit, Control
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Complications
Incidence and Risk Factors of Ocular Complications Among Patients With Homocystinuria
Background: Cysteine beta-synthase (CBS) deficiency, often known as classic homocystinuria (HCU), is an uncommon inborn mistake in methionine metabolism.
- Trial name
- NCT06545305
- Testing
- Lensectomy and vitrectomy
- Where
- Saudi Arabia
- Volunteers
- 6 people
- Sponsor
- King Fahad Armed Forces Hospital
Chronic Kidney Disease
Risk Factors for Foot Ulceration in the Chronic Kidney Disease (CKD) Population
Foot ulceration is a risk factor that has been associated with early death in patients with chronic kidney disease. Little is known about the relationship between these risk factors that develop in patients with kidney failure…
- Trial name
- NCT01089829
- Testing
- Foot examination
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Cardiff University
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