Clinical trials: Metabolic Risk Factors
Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance
Diabetes Prevention Program
The Diabetes Prevention Program is a nationwide clinical study to answer the question: Can Type 2 diabetes (also called noninsulin-dependent or adult-onset diabetes) be prevented or delayed? The study has recruited volunteers…
- Trial name
- NCT00004992
- Testing
- Intensive lifestyle, Metformin
- Where
- United States
- Volunteers
- 3,234 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Depression, Hypertension
Biological CVD Risk Factors in Older Depressed Patients
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g.
- Conditions
- Depression, Hypertension, Hypercholesterolemia
- Trial name
- NCT00318864
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sedentary Lifestyle, Cardiovascular Diseases
Physical Exercise Prescription With PEdometeR in General Practice for Patients With Cardiovascular Risk Factors - PEPPER
This study evaluates the efficacy, in terms of energy expenditure, physical activity level, quality of life, blood pressure, waist circumference and weight, of a general practice based intervention involving a personalised…
- Conditions
- Sedentary Lifestyle, Cardiovascular Diseases, Hypertension, Hypercholesterolemia
- Trial name
- PEPPER (NCT02317003)
- Testing
- Intervention PPIL, Control OR
- Where
- France
- Volunteers
- 126 people
- Sponsor
- University Hospital, Angers
Schizophrenia
Examining Risk Factors for Atypical Antipsychotic Metabolic Side Effects
This study will examine possible causes of metabolic side effects in people taking atypical antipsychotic (AAP) medications.
- Trial name
- NCT00815854
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Michigan
Obesity
Neuromolecular Risk Factors for Obesity (PROSPECT)
The goal of this project is to characterize the neural and psychological mechanisms that contribute to development of obesity in the early adulthood.
- Trial name
- NCT03106688
- Testing
- fMRI imaging, [11C]carfentanil PET scan, [18F]FMPEP-d2 PET scan
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Overweight and Obesity, Overweight
Piloting a Reinforcement Learning Tool for Individually Tailoring Just-in-time Adaptive Interventions
The purpose of this pilot study is to conduct a 12-week pilot feasibility study testing usability of a reinforcement learning model (AdaptRL) in a weight loss intervention (ADAPT study).
- Conditions
- Overweight and Obesity, Overweight, Obesity
- Trial name
- NCT05751993
- Testing
- ADAPT
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Obesity, Inflammation
Effect of Diet Composition on Weight Change and Metabolic Parameters
This study will assess the effect of high protein (HP) and high carbohydrate (HC) diets on weight loss and other metabolic parameters. Rationale: The prevalence of obesity is on the rise in the US.
- Trial name
- NCT01642849
- Testing
- high protein diet, high carbohydrate diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Postmenopause Women
Effect of 12-week FW Programme on Sex Hormone Levels and Risk Factors for MS in Postmenopausal Women
Postmenopausal women were separated into two groups: one participating in a 12-week fitness walking programe as the fitness walking group, and the other maintaining their regular lifestyle as the control group.
- Trial name
- NCT06454032
- Testing
- Fitness walking, Maintained lifestyle
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Adiposity
Vitamin D and Omega-3 Adiposity Trial (VITAL Adiposity)
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is a randomized clinical trial in 20,000 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (1 gram of…
- Trial name
- VITAL (NCT01785004)
- Testing
- Vitamin D3 (cholecalciferol), 2000 IU per day, omega-3 fatty acids (fish oil)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Risk Factors, Hypertension
Clinical Management of Cardiovascular Risk Factors in Adult Patients: A Before-and-After Interventional Study
This study aims to evaluate cardiovascular risk factors, clinical characteristics, and outcomes in adult patients attending an outpatient cardiology clinic.
- Conditions
- Cardiovascular Risk Factors, Hypertension, Dyslipidemia, Type 2 Diabetes Mellitus
- Trial name
- CV-RISK (NCT07447362)
- Testing
- Structured Cardiovascular Risk Management
- Where
- Chile
- Volunteers
- 220 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Medication Adherence
Lifestyle, Self-medication and Use of Nutraceuticals in a Population of Italian and Spanish Students
University students are considered a population class with a high risk of malnutrition and/or obesity, metabolic and cardiovascular diseases, with a tendency to misuse drugs and self-medication.
- Trial name
- STANIS (NCT04099420)
- Testing
- Lifestyle counseling
- Where
- 3 sites in Italy, Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Maura Palmery
COVID-19, Cardiovascular Risk Factor
Predictors of Cardiovascular Risk in Covid-19 Patients During Acute Disease and at Short Term Follow-up
Northern Italy, and particularly Lombardy, is one of the regions of the world mostly affected by COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
- Trial name
- CARDICoVRISK (NCT04371289)
- Where
- Italy
- Volunteers
- 4,356 people
- Sponsor
- Istituto Auxologico Italiano
Gestational Diabetes
Risk Factors and Diagnostic Performance of Predictors as a Screening Technique for Gestational Diabetes Mellitus
Background Gestational diabetes mellitus (GDM) is a condition that can have negative impacts on both mother and baby. Detecting GDM early is crucial, and fasting plasma glucose (FPG) has been suggested as a possible screening…
- Trial name
- NCT06109597
- Testing
- 75 g glucose tolerance test
- Where
- Saudi Arabia
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Diabetes Mellitus, Hyperglycemia
Durban Diabetes Study:A Study of the Epidemiology of Diabetes Mellitus in Urban South Africans of African Descent (DDS)
Type 2 diabetes (T2D) is an emerging epidemic in sub-Saharan Africa, with an estimated prevalence of 6%. With around seven million cases of T2D in 2000, it is anticipated that over 18 million Africans will have the disease by…
- Conditions
- Diabetes Mellitus, Hyperglycemia, Hereditary Diseases, Glucose Intolerance
- Trial name
- DDS (NCT02416440)
- Testing
- blood sample
- Where
- South Africa
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Acute Pancreatitis (AP), Diabetes Mellitus
Endocrine and Exocrine Secretory Function Alterations After Moderately Severe and Severe Acute Pancreatitis
The goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (PPDM-A). The main questions it aims to answer are: 1.
- Trial name
- NCT06590935
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Changzheng Hospital
Cardiovascular Diseases, Acute Myocardial Infarction
Biomarkers Predicting Acute Myocardial Infraction in Patients Without Standard Modifiable Risk Factors
Coronary heart disease (CHD) is the leading cause of mortality worldwide. Every year, millions of people suffer its most adverse manifestation, an acute myocardial infraction (AMI).
- Conditions
- Cardiovascular Diseases, Acute Myocardial Infarction, Acute Coronary Syndrome, Metabolic Disturbance
- Trial name
- BeyondSMuRFs (NCT05535582)
- Testing
- Investigation of clinical, laboratory and imaging profile
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- Aristotle University Of Thessaloniki
Abdominal Obesity, Metabolic Syndrome
WAVE Study- Walking and Aging in VErona Study
Monocentric unblinded two parallel-group randomized controlled trial to evaluate the effect of diet with or without Nordic Walking on weight loss, physical performance and cardiovascular risk factors in overweight and obese…
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Disability Physical, Sarcopenic Obesity
- Trial name
- WAVE (NCT03212391)
- Testing
- Diet, Walking, Nordic Walking
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Diabetes Mellitus, Hypertension
Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini
The WHO-PEN@Scale project is a three-arm cluster-randomized trial that is investigating the population-level effects of a healthcare reform in Eswatini, which aims to strengthen primary care for diabetes and hypertension.
- Trial name
- NCT04183413
- Testing
- DSD, CDP
- Where
- Eswatini
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Metabolic Syndrome, Overweight and Obesity
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes
- Trial name
- NCT05191160
- Testing
- Soy Milk, Cow's Milk, Sugar Sweetened Beverages
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes Mellitus
Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes
Dapagliflozin is a member of the sodium-glucose cotransporter-2 (SGLT2) inhibitor class antidiabetes agents which produces significant and sustained reductions in glycemic parameters in patients with type 2 diabetes (T2DM).
- Trial name
- NCT03377335
- Testing
- Dapagliflozin 10mg, Metformin
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- University of Palermo
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