Clinical trials: Metabolic and Bariatric Surgery
Obesity, Morbid
The Effect of High Protein Diets on Weight Loss and Lean Muscle Mass in Patients Awaiting Bariatric Surgery
All patients in CMDHB eligible for bariatric surgery are given a weight loss goal prior to surgery. It is unknown what the most effective diet is to lose weight, while still preserving muscle mass.
- Trial name
- NCT02631707
- Testing
- High protein diet
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Morbid Obesity, Postoperative Pain
Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery
This prospective randomized controlled trial aims to compare the clinical effectiveness and safety of opioid-free anesthesia (OFA) versus traditional opioid-based anesthesia (OBA) in adult patients undergoing laparoscopic…
- Conditions
- Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia, Bariatric Surgery
- Trial name
- NCT07337135
- Testing
- Opioid-Based Anesthesia (Remifentanil-Based Protocol), Opioid-Free Anesthesia (Dexmedetomidine-Ketamine-Lidocaine Protocol)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Hospital dos Lusíadas
Diabetes Mellitus, Ketoacidosis
Expected Normal Ketone Values After Very Low and Bariatric Surgery
The investigators propose a multicenter prospective study in patients undergoing either an elective bariatric procedure or an elective benign procedure, including laparoscopic/open cholecystectomy, laparoscopic/open hiatus hernia…
- Trial name
- NCT05442918
- Where
- Australia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- St Vincent's Hospital Melbourne
Obesity, Bariatric Surgery
Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy
Ultrasound-guided Modified Thoracoabdominal Nerve Plane Block (M-TAPA) is performed into the costochondral aspect at the 9th-10th costal level by injecting local anesthetics deep into the chondrium.
- Conditions
- Obesity, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy, Acute Post Operative Pain
- Trial name
- NCT06515691
- Testing
- M-TAPA block, Postoperative pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
Anesthesia, Obesity
Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients
Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.
- Trial name
- NCT03417518
- Testing
- Desflurane Inhalant Product, Propofol
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Hypo- and Hyperglycemia Following Bariatric Surgery, Association Between Glucose Excursions, Fetal Growth and Neonatal Body Composition
The BAMBI II Study
Background Bariatric surgery (BS) is an efficient treatment of severe obesity and diseases like female infertility. Almost half of the population having BS are women of reproductive age, and BMI above 35 kg/m2 and infertility…
- Trial name
- NCT07578597
- Testing
- CGM, Activity tracker, Blood samples
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Odense University Hospital
Obesity/therapy
Rhomboid Intercostal Block with Subserratus Plane Block in Bariatric Surgery
Standard analgesic techniques such as patient-controlled analgesia (PCA) and continuous epidural analgesia (CEA) are effective but associated with considerable side effects, including nausea, hypotension, and respiratory…
- Trial name
- NCT06729515
- Testing
- PCA, CEA, RISS
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Xiaguang Duan
Bariatric Surgery, Roux-en Y Gastric Bypass
Gastro-Intestinal Digestion and Physiology After Bariatric Surgery
The goal of this clinical trial is to characterize gastrointestinal digestion and physiology in patients after bariatric surgery, or people living with obesity.
- Conditions
- Bariatric Surgery, Roux-en Y Gastric Bypass, Sleeve Gastrectomy, Obesity & Overweight
- Trial name
- GIBa (NCT07286968)
- Testing
- Gastro-intestinal aspiration, Telemetric
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bariatric Surgery Candidate, Obesity
A Preoperative Cognitive Behavioural Therapy Program Based on Self-determination Theory for Bariatric Surgery Candidates
The objective of this study is to evaluate the impact of a pre-surgical intervention program based on Cognitive and Behavioural Emotional Therapies, on the degree of dietary restriction of patients who are candidates for…
- Trial name
- ACRoBAT (NCT03976674)
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Lille Catholic University
Diabetes Mellitus, Type 2, Obesity
Evaluation of the Metabolic Surgery Technique for Glycemic Improvement in Type 2 Diabetes
Surgery is one of the management options for type 2 diabetes in patients with moderate obesity. This is a recent option because it has been part of the recommendations since October 2022.
- Trial name
- CHANGE (NCT06600555)
- Testing
- metabolic surgery with SLEEVE technique, metabolic surgery with BY-PASS technique
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Médipôle Lyon-Villeurbanne
Bariatric Surgery (Gastric Bypass), Overweight
The Effect of Different Macronutrients on Gastrointestinal Hormone Secretion After Gastric Bypass Operation
The purpose of this study is to determine the type of macronutrient (carbohydrate, lipid or protein) that most potently stimulates the endogen secretion of different gut hormones (primary outcome = Glucagon-Like peptide-1) in…
- Trial name
- NCT02372526
- Testing
- Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kirstine Nyvold Bojsen-Moeller
Obesity &Amp; Overweight
Evaluation of the Care Provided to Patients Who Underwent Bariatric Surgery and Were Lost to Follow-up 5 Years After Surgery
In 2025, bariatric surgery combined with nutritional and psychological support is one of the most effective treatments for patients with morbid obesity.
- Trial name
- OBEPER (NCT07118540)
- Where
- 2 sites in France
- Volunteers
- 176 people
- Sponsor
- Central Hospital, Nancy, France
Bariatric Surgery Candidate, Vitamin Deficiency
Absorption of Transdermal Vitamins in Post Bariatric Surgery Patients
Patients undergoing bariatric surgery often develop new vitamin and/or mineral deficiencies or exacerbate prior deficiencies after surgery.
- Conditions
- Bariatric Surgery Candidate, Vitamin Deficiency, Mineral Deficiency
- Trial name
- NCT03360435
- Testing
- Patch MD MultiVitamin Plus patch
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hypoglycemia, Cerebral Blood Flow
External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia
This is a pilot study (small-scale study) that aims to understand more about how blood flow changes in people who have low blood sugar after bariatric surgery (post-bariatric hypoglycemia) compared to those who have had surgery…
- Trial name
- NCT07082478
- Testing
- in-ear device measuring blood flow
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Obesity
Clinical Significance of Alveolar Recruitment Maneuver During Bariatric Surgery
The ventilation of the patient under general anesthesia is an old problem and extensively studied, especially in visceral surgery, higher risk of postoperative complications.
- Trial name
- NCT02592226
- Testing
- Anesthesia: alveolar recruitment maneuver, Anesthesia: standardized
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Loss-of-control Eating, Obesity/Overweight
Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1)
This study will compare the effectiveness of behavioral and pharmacologic treatments, alone and in combination, for the treatment of loss-of-control eating and weight following bariatric surgery.
- Trial name
- NCT04599478
- Testing
- Naltrexone and Bupropion medication, Behavioral Weight Loss
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Yale University
Morbid Obesity Requiring Bariatric Surgery
Midterm Follow up Outcomes of (SASJ) in Management of Morbid Obesity
Obesity is a critical health problem associated with an increased risk of cardiovascular disease, diabetes, and cancers, affecting both the quality of life and life expectancy .
- Trial name
- NCT07087535
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Non-Diabetic
The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery
The goal of this study is to understand the role of glucagon signal on glucose metabolism in individuals with and without bariatric surgery.
- Trial name
- NCT07212868
- Testing
- Exogenous glucagon versus saline infusion
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
De Novo Lipogenesis in Severity of NAFLD
NAFLD is the most prevalent liver disease in the U.S., and there is a serious need to understand its progression to the advanced state, nonalcoholic steatohepatitis (NASH).
- Conditions
- Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, Bariatric Surgery Candidate, Obesity, Morbid
- Trial name
- NCT03683589
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Missouri-Columbia
Obesity, Weight Loss
Impact of the Excess Weight Loss on Mineralization Patterns of the Knee After Bariatric Operations
Evaluation of the subchondral mineralization plate after excess weight loss in patientes undergoing bariatric operation by means of CT-osteoabsorptiometry.
- Conditions
- Obesity, Weight Loss, Knee Osteoarthritis
- Trial name
- CT-OAM (NCT02404090)
- Testing
- CT-osteoarbsorptiometry
- Volunteers
- 50 people
- Sponsor
- Marko Kraljevic
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