Clinical trials: Metabolic and Bariatric Surgery
NAFLD, Obesity, Morbid
Integrated Multi-omics Data for Personalized Treatment of Obesity-associated Fatty Liver Disease
The investigators seek to analyze the samples provided by patients with obesity-associated fatty liver disease at the multi-omics level and to integrate the results with clinical information, genotypic variants, and factors…
- Conditions
- NAFLD, Obesity, Morbid, Comorbidities and Coexisting Conditions
- Trial name
- NCT05554224
- Testing
- To propose diagnostic tests for liver diseases before surgical decisions.
- Where
- Spain
- Volunteers
- 1,104 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Obesity, Morbid, Obesity
Effects of Very Low Calorie Diet vs Metabolic Surgery on Weight Loss and Obesity Comorbidities
It is a prospective randomized trial on 218 subjects, 109 for each arms. The purpose of this trial is to compare very low calorie diet and metabolic surgery induced weight loss and its maintenance.
- Conditions
- Obesity, Morbid, Obesity, Diet, Healthy, Bariatric Surgery Candidate
- Trial name
- ARGOS (NCT04583683)
- Testing
- Very low calorie diet with Fortimel (Nutricia) supplementation, Metabolic Surgery
- Where
- Italy
- Volunteers
- 218 people
- Sponsor
- Catholic University of the Sacred Heart
Obesity, Vestibular Function Disorder
Vestibular Function in Obesity
Previous studies have demonstrated that obesity negatively affects the human vestibular system. However, whether improvement in vestibular function occurs following the resolution of obesity remains an area requiring further…
- Conditions
- Obesity, Vestibular Function Disorder, Balance Assessment, Balance Impairment
- Trial name
- NCT07033221
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Aydın University
Obesity
Naltrexone/Bupropion (Mysimba) to Optimize Weight Outcomes After Obesity Surgery
Limited/poor weight loss and weight regain are concerns following bariatric surgery, and weight regain may increase the risk for relapse of comorbidities related to obesity.
- Trial name
- NCT04399395
- Testing
- Naltrexone/bupropion, Lifestyle
- Sponsor
- Oslo University Hospital
Perioperative Care, Bariatric Surgery
Do Text Message Reminders Increase Preoperative Exercise in Obesity Surgery Candidates?
Preoperative exercise has been shown to improve physiological and functional capacity in patients undergoing abdominal surgery to prepare them for the stress of surgery.
- Conditions
- Perioperative Care, Bariatric Surgery, Obesity
- Trial name
- NCT01607177
- Testing
- Daily text message reminders
- Where
- New Zealand
- Volunteers
- 102 people
- Sponsor
- University of Auckland, New Zealand
Obesity, Neostigmine
Observational Study in Bariatric Surgery
Obesity in the world represents a growing share of the general population. At hospital, the management of these patients could be problematic especially when calculating the drug dosage.
- Conditions
- Obesity, Neostigmine, Residual Neuromuscular Blockade
- Trial name
- NEOCURE (NCT04244266)
- Testing
- NO INTERVENTION, it is an observational study
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Bariatric Surgery, Obesity, Morbid
Use of Electroanalgesia in Pain and Pulmonary Function.
It is a consensus in the literature that changes in lifestyle and carbohydrate-rich diet are part of a context that has led to an obesity pandemic.
- Trial name
- NCT04800640
- Testing
- Experimental: Electroanalgesia
- Where
- Brazil
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Augusto Motta
Obesity
Effect of Diet Versus Sleeve Gastrectomy and Gastric Bypass on Appetite
The biggest challenge in obesity management is maintaining weight loss in the long-term. Currently, bariatric surgery is the most effective treatment, leading to sustained weight loss that is not yet achievable with lifestyle…
- Trial name
- DISGAP (NCT04051190)
- Testing
- VLED group, Sleeve Gastrectomy group, Gastric Bypass group
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Laparoscopic Single Anastomosis Sleeve Ileal Bypass Versus Laparoscopic Sleeve Gastrectomy for Morbid Obesity
This study will compare two bariatric surgical interventions in terms of weight loss, gastroesophageal reflux, and effects on obesity-related comorbid conditions in morbidly obese patients.
- Trial name
- NCT05611697
- Testing
- Single anastomosis sleeve ileal bypass, Sleeve gastrectomy
- Where
- 2 sites in Norway
- Volunteers
- 220 people
- Sponsor
- Oslo University Hospital
Morbid Obesity
Follow-up of Adolescent Bariatric Surgery
Very little information is available about extremely obese (body mass index [BMI] > 40 kg/m2) adolescents. The purpose of the Follow up of Adolescent Bariatric Surgery (FABS) study is to collect information obtained during the…
- Trial name
- FABS (NCT00776776)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diabetes Mellitus, Type 2, Obesity
CARAT: Canagliflozin vs. Placebo for Post Bariatric Patients With Persistent Type 2 Diabetes
This is a prospective, randomized clinical trial for patients with recurrent type 2 diabetes post-gastric bypass surgery that will compare a 6 month course of canagliflozin monotherapy vs.
- Trial name
- NCT02912455
- Testing
- canagliflozin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The Cleveland Clinic
Obesity
Study of Food Preferences and Sensory Perceptions After Bariatric Surgery
Several studies report changes in food preferences in favor of low energy density foods after bariatric surgery and changes in scores of liking and desire to eat, as well as changes in hedonic evaluation certain foods.
- Trial name
- BariaTaste 2 (NCT04511442)
- Testing
- Evaluation of food preferences during a standardized and validated buffet.
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Hospices Civils de Lyon
Obesity
Quality of Life and Body Image in Women Underwent Thighplasty
Obesity is a chronic disease now considered a major public health concern in the global context, as it causes or exacerbates many diseases limitations in providing quality of life and higher treatment costs.
- Trial name
- NCT01453231
- Testing
- thighplasty
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Obesity
Mechanisms Underlying Predictors of Success From Obesity Surgery
The goal of this project is to identify predictors of success in the treatment of obesity after bariatric surgery. The specific aims of this proposal are to: 1.
- Trial name
- NCT02697253
- Testing
- Exendin 9-39 and Sitagliptin
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bariatric Surgery Candidate, Diabetes
Surgery Versus Best Medical Management for the Long Term Remission of Type 2 Diabetes and Related Diseases (REMISSION)
Bariatric surgery procedures induce weight loss through restriction and/or malabsorption. The mechanisms underlying type 2 diabetes remission and others metabolic improvements after Roux-en-Y Gastric Bypass (RYGB), sleeve…
- Trial name
- REMISSION (NCT02390973)
- Testing
- Sleeve Gastrectomy, Roux-en-Y Gastric Bypass, Biliopancreatic Diversion with Duodenal Switch
- Where
- Canada
- Volunteers
- 408 people
- Sponsor
- Laval University
Obesity
Postoperative Dietary Counseling After Bariatric Surgery
This study aims to assess the changes in physical characteristics, food intake, eating behavior, vomiting, and dumping in 100 patients who undergo bariatric surgery.
- Trial name
- NCT00125073
- Testing
- Postoperative nutritional counseling
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Morbid Obesity
Effect of Bariatric Surgery on Bile Acid Homeostasis
The purpose of this study is to evaluate the effect of bariatric surgery in bile acid homeostasis and its interrelationship with the metabolic changes induced by the surgery.
- Trial name
- NCT02366624
- Where
- Chile
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Metabolic Syndrome
Effect of Bariatric Surgery Versus Medical Therapy on Metabolic Syndrome
Bariatric surgery (BS) is known to improve the components of metabolic syndrome (MS) in obese patients. However, few studies have evaluated the impact of bariatric surgery versus medical therapy (MT) in patients with MS…
- Trial name
- EBSMTMS (NCT05363059)
- Testing
- Hypoglycemic drugs, Bariatric surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Military Medical University
Morbid Obesity, Bariatric Surgery Candidate
Intravenous Lidocaine in Bariatric Surgery.
Although peroperative intravenous lidocaine has been shown to be useful in early recovery after colorectal surgery, its beneficial effect on the specific population of obese patients scheduled for bariatric surgery remained…
- Trial name
- XYLOBAR (NCT03211455)
- Testing
- Lidocaine, isotonic saline
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Kidney Hypoxia, Diabetes Mellitus, Type 2
The Effects of Bariatric Surgery on Kidney Oxygenation in Obese Adults With Type 2 Diabetes and Hyperfiltration
In this study the investigators will examine the effects of VAT reduction by bariatric surgery on kidney hypoxia and compare kidney oxygenation before- and after surgery in both sexes using BOLD-MRI and measures of kidney…
- Trial name
- ECSTASY (NCT06284785)
- Testing
- Bariatric surgery
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
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