Clinical trials: Metabolic and Nutritional Disorders
Diabetes, Memory Impairment
Strengthening, Engaging, and Empowering Dyads Through Nutrition & Wellness
A meta-analysis of over 2.3 million individuals in 14 studies showed that individuals with type II diabetes (T2DM) are at a 60% increased risk for development of any dementia compared to those without T2DM.
- Trial name
- SEED (NCT06473129)
- Testing
- Food for Life Culinary Workshops
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Montefiore Medical Center
Cancer, Malnutrition (Calorie)
Evaluation of Safety and Efficacy of Supportan® Drink
The goal of this clinical trial is to demonstrate safety and efficacy of Supportan® Drink
- Trial name
- NCT06902402
- Testing
- Supportan® Drink
- Where
- Taiwan
- Volunteers
- 135 people
- Sponsor
- Fresenius Kabi Taiwan Ltd.
Insulin Resistance, Type2 Diabetes Mellitus
High-fat Overfeeding, Hepatokines and Appetite Regulation
The present study will investigate the effect of high-fat overfeeding on a group of liver-secreted proteins linked to worsened blood sugar control, as well as proteins involved in appetite control.
- Conditions
- Insulin Resistance, Type2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity
- Trial name
- OVEREAT (NCT03369145)
- Testing
- High-fat diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
PCOS, Obesity
PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome
The purpose of this study was to determine whether combined treatment with phosphodiesterase-4 (PDE-4) inhibitor roflumilast and metformin is more effective than metformin as monotherapy in the treatment of obese women with…
- Trial name
- NCT02037672
- Testing
- metformin, metformin and roflumilast
- Where
- Slovenia
- Volunteers
- 36 people
- Sponsor
- University Medical Centre Ljubljana
Type 2 Diabetes Mellitus, Obesity
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance
Agonistic activation of fat metabolite responsive G-protein-coupled receptors (GPCR) has been linked to improved glucose metabolism through increased glucose-stimulated-insulin-secreting (GSIS) and incretin release, improved…
- Trial name
- NCT03774095
- Testing
- Hydrolyzed pine nut oil, Hydrolyzed pine nut oil and olive oil
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karina Vejrum Sørensen
Healthy, Obesity
A Pharmacokinetic Study to Compare the Dosing of Valproic Acid in Subjects With Different Body Weights
The purpose of this study is to compare the blood levels of valproic acid in subjects with different body weights and to evaluate whether the pharmacokinetic parameters of this drug is altered in the obese population.
- Conditions
- Healthy, Obesity, Pharmacokinetics
- Trial name
- NCT00298857
- Testing
- Valproic acid
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Type 2 Diabetes
Comparing Self Monitored Blood Glucose (SMBG) to Continuous Glucose Monitoring (CGM) in Type 2 Diabetes
The purpose of this study is to evaluate the use of SMBG and CGM for clinical decisions related to the management of type 2 diabetes.
- Trial name
- REACT3 (NCT01237301)
- Testing
- CGM Group, SMBG Group
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- HealthPartners Institute
Diabetes Mellitus, Non-Insulin-Dependent
An Evaluation of an Oral Antidiabetic Agent for the Treatment of Type 2 Diabetes
The purpose of this study is to determine if an investigational drug is safe and efficacious for poorly controlled type 2 diabetes mellitus.
- Trial name
- NCT00065312
- Testing
- naveglitazar
- Where
- 42 sites in United States
- Sponsor
- Eli Lilly and Company
Cardiovascular Autonomic Neuropathy, Type 2 Diabetes
Finerenone Treatment for Diabetic Cardiovascular Autonomic Neuropathy: the FibroCAN Study
Diabetic neuropathy is a serious and common complication of diabetes that currently has no cure. One form of this condition is cardiovascular autonomic neuropathy (CAN), which affects about 20% of people with diabetes-an…
- Conditions
- Cardiovascular Autonomic Neuropathy, Type 2 Diabetes, Diabetic Neuropathies
- Trial name
- FibroCAN (NCT06906081)
- Testing
- Kerendia (Finerenone, BAY94-8862)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Peter Rossing
Frailty, Malnutrition
Frail2Fit Study: Online Nutrition and Exercise Support for Older Adults With Frailty
Frail2Fit will explore the feasibility of training volunteers to deliver online nutrition, exercise, and behaviour change (supported self-management) to improve the health of older people after discharge from hospital.
- Conditions
- Frailty, Malnutrition, Sedentary Behavior
- Trial name
- NCT05384730
- Testing
- Group nutrition and exercise support
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Type 2 Diabetes
The Effect of LINAGLIPTIN on Inflammation, Oxidative Stress and Insulin Resistance in Obese Type 2 Diabetes Subjects
This is a single center, prospective randomized double blind, parallel and placebo controlled study to evaluate oxidative stress and inflammation before and after treatment with linagliptin for 12 weeks.
- Trial name
- 1971 (NCT02372630)
- Testing
- Linagliptin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University at Buffalo
Obesity, Cardiovascular Diseases
Comparison of Workplace Obesity Management Programs
The purpose of this study is to design and demonstrate the feasibility of implementing moderate and intensive environmental obesity prevention programs at major worksites.
- Conditions
- Obesity, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00122928
- Testing
- Diet, Exercise, Environmental Obesity Program - Healthy Culture
- Volunteers
- 5,124 people
- Sponsor
- Emory University
Diabetes Mellitus
Feasability of a Care Pathway Integrating Collaborative Tele-expertise to Prevent Recurring Hospitalisations for Diabetic Patients
Telemedicine for diabetic patients is currently based simply on remotely monitoring capillary blood glucose levels. This experimental approach remains limited to insulin-treated diabetic patients with sufficient motivation and…
- Trial name
- TELXCODIA (NCT04769765)
- Testing
- Definition of the Individualized Care Pathway
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Periodontitis, Type 2 Diabetes
Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients
This study investigates the relationship between Type 2 diabetes mellitus (T2DM), glycemic control, and periodontal disease. Researchers analyzed the levels of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines…
- Conditions
- Periodontitis, Type 2 Diabetes, Glycemic Control
- Trial name
- NCT06803836
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Homozygous Familial Hypercholesterolemia
A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH)
The purpose of this study is to assess the safety, tolerability, and efficacy of ALN-PCSSC in participants with homozygous familial hypercholesterolemia.
- Trial name
- ORION-2 (NCT02963311)
- Testing
- ALN-PCSSC, Standard of Care
- Where
- 3 sites in United States, Netherlands and 1 more
- Volunteers
- 9 people
- Sponsor
- The Medicines Company
Type2 Diabetes, Type1diabetes
Accuracy Characterization Study
To demonstrate point accuracy of the Abbott Sensor Based Glucose Monitoring System (System) interstitial glucose results against venous glucose reference and capillary fingerstick using the Consensus Error Grid over the wear…
- Conditions
- Type2 Diabetes, Type1diabetes, Insulin Dependent Diabetes
- Trial name
- ACS (NCT01932944)
- Testing
- No treatment
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Abbott Diabetes Care
Coronary Disease, Hypolipoproteinemia
Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)
The investigators want to study the relative effects of physical exercise vs. extended-release niacin (lipid-lowering drug) in patients with coronary heart disease and low HDL cholesterol ("good cholesterol") on lipid profile…
- Trial name
- NCT00298909
- Testing
- physical exercise, niaspan (extended-release niacin), niacin
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Leipzig
Obesity
RCT Comparing OAGB and Long Limb Roux Gastric Bypass
A prospective multicenter randomized controlled trial to compare the outcomes of one-anastomosis gastric bypass to long biliary limb Roux gastric bypass.
- Trial name
- OAGBvsLLbypass (NCT04812132)
- Testing
- One-anastomosis gastric bypass, Long biliary limb Roux gastric bypass
- Where
- Estonia
- Volunteers
- 500 people
- Sponsor
- Tartu University Hospital
Type 2 Diabetes Mellitus
FTIH of ECC5004 in Healthy and Diabetic Participants
This is a Phase 1, randomized, double-blind, placebo-controlled, single ascending dose and multiple ascending dose study of ECC5004 in healthy participants and in patients with Type 2 Diabetes Mellitus
- Trial name
- NCT05654831
- Testing
- ECC5004
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Eccogene
Diabetes, Type 1 Diabetes
The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes
The purpose of this study is to determine if the drug Alpha-1 Antitrypsin (AAT, Aralast NP) will preserve beta-cell function and help slow the progression of type 1 diabetes.
- Trial name
- NCT01319331
- Testing
- Alpha 1-Antitrypsin (AAT, Aralast NP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
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