Clinical trials: Metabolic and Nutritional Disorders
Hypercholesterolemia
A Study to Evaluate the Effects of Ezetimibe (MK-0653) on the Postprandial (Following a Meal) Lipoprotein Response in Participants With Primary Hypercholesterolemia (High Cholesterol) (MK-0653-072)(COMPLETED)
A study to evaluate the cholesterol-lowering effects of ezetimibe in participants with primary hypercholesterolemia (high cholesterol) after eating a meal that is high in cholesterol.
- Trial name
- NCT00101439
- Testing
- ezetimibe
- Volunteers
- 58 people
- Sponsor
- Organon and Co
Obesity, Hypertrophic Cardiomyopathy
Association of Obesity and Cardiovascular Outcomes in Hypertrophic Cardiomyopathy
In this study, the investigators evaluated the association between various measures of adiposity [BMI and waist circumference (WC)] and clinical outcomes in Asian patients with hypertrophic cardiomyopathy, using a nationwide…
- Conditions
- Obesity, Hypertrophic Cardiomyopathy, Cardiovascular Morbidity
- Trial name
- Paradox (NCT05645939)
- Testing
- Diasgnosis of hypertrophic cardiomyopathy
- Where
- South Korea
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Vitamin D Deficiency, Covid19
The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection
Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis…
- Trial name
- NCT04945577
- Testing
- Inflammatory Parameters, 25 OH Vitamin D Level
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Type 2 Diabetes
A Study to Assess the Pharmacokinetics, Safety and Tolerability of Sitagliptin in Adolescents (0431-081)
This study will assess the safety, tolerability and pharmacokinetics of sitagliptin in 10 to 17 year old diabetic patients.
- Trial name
- NCT00730275
- Testing
- Sitagliptin phosphate
- Volunteers
- 35 people
- Sponsor
- Merck Sharp & Dohme LLC
Latent Autoimmune Diabetes in Adults (LADA)
Hybrid Closed-Loop System in LADA Patients: A Randomized Trial
Based on the difficulties in blood glucose control among the Latent Autoimmune Diabetes in Adults (LADA) population and the deficiencies of previous studies, this research aims to conduct a clinical comparative study.
- Trial name
- NCT06941675
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanxi Bethune Hospital
Polycystic Ovary Syndrome (PCOS), Metabolic Syndrome
Malay Women With PCOS and Their Association With Metabolic Syndrome
The abnormalities that characterize the Metabolic Syndrome (MetS) confer an increased risk of cardiovascular and other diseases.
- Trial name
- MPMSS (NCT03414957)
- Testing
- Hormonal and biochemical blood tests and ultrasound scanning
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cyberjaya University College of Medical Sciences
Glucose Intolerance
Carnitine Supplementation in Type 2 Diabetic Patients
the results from animal studies and preliminary human studies show that carnitine availability and acetylcarnitine concentrations are low in insulin resistant states such as with type 2 diabetes mellitus.
- Trial name
- NCT03230812
- Testing
- Carnitene (L-Carnitine or Levocarnitine)
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Maastricht University Medical Center
Obesity
The Impact of an Investment Based Intervention on Weight-loss and Beliefs About Food in Patients Post Bariatric Surgery
Although obesity surgery is currently the most effective method for achieving weight loss, not all patients lose the desired amount of weight and some show weight regain.
- Trial name
- NCT02045628
- Testing
- Investment intervention
- Where
- United Kingdom
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Type 2 Diabetes, Self-management
The Effect of Telephone Consulting on HbA1 and Self-Management
The aim of this study was to investigate the effect of telephone counseling (12 weeks) based on the Information, Motivation, Behavioral Skills (IMB) Model in patients with type 2 diabetes mellitus (T2DM) on self-management and…
- Trial name
- NCT04723628
- Testing
- Intervention group (telephone counseling)
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Aksaray University
Amyotrophic Lateral Sclerosis, ALS
An Efficacy and Safety Study of Ravulizumab in ALS Participants
The purpose of the study is to assess the efficacy and safety of ravulizumab for the treatment of adult participants with ALS.
- Trial name
- NCT04248465
- Testing
- Ravulizumab
- Where
- 95 sites in United States, Australia and 15 more
- Volunteers
- 382 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Type 1 Diabetes
Audio Health Engagement Analysis in Diabetes: The AHEAD Study
Despite multidisciplinary care and advancements in therapeutics and technology, health outcomes remain suboptimal in pediatric diabetes centers world-wide.
- Trial name
- NCT01938807
- Testing
- CareCoach mobile application to assist in diabetes management
- Volunteers
- 43 people
- Sponsor
- University of California, San Francisco
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Hepatic Encephalopathy, Hypertension, Portal
Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy
Comparison between the efficacy of two different antibiotics in patients with overt hepatic encephalopathy. The study is randomized, controlled and double-blinded.
- Conditions
- Hepatic Encephalopathy, Hypertension, Portal, Liver Cirrhosis
- Trial name
- NCT01097811
- Testing
- Erythromycin, Neomycin
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Obesity, Morbid Obesity
Bariatric Embolization of Arteries With Imaging Visible Embolics (BEATLES)
The BEATLES study is an investigator-initiated, prospective, double-blinded, randomized, sham-controlled study that will assess the impact of bariatric embolization on the systemic levels of obesity-related hormones and, as a…
- Conditions
- Obesity, Morbid Obesity, Weight Loss
- Trial name
- BAE2 (NCT04197336)
- Testing
- Bariatric Embolization of Arteries with imaging visible Embolics
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity
Using Online Tools to Increase Weight Loss in Primary Care
The goal of the proposed project is to test the effectiveness of an intervention (Connect4Health Engage) focused on motivating and guiding patients to use empirically supported, freely available online tools for weight loss.
- Trial name
- NCT06928571
- Testing
- Connect4Health Engage, Connect4Health Discover
- Where
- United States
- Volunteers
- 473 people
- Sponsor
- University of Florida
Diabetes Mellitus
The Relative Bioavailability of INS068 Injection With Two Different Formulations in Healthy Subjects
The study is a single-centre, randomized, open, 2-period, 2-sequence crossover design clinical trial. It is planned to enroll 24 healthy male subjects. Subjects will receive INS068 injection on Day1 and Day8.
- Trial name
- NCT05336071
- Testing
- INS068 injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Obesity
A School-based Gardening Obesity Intervention for Low-income Minority Children
The investigators recently completed an NIH R21 grant, which was a randomized controlled trial (RCT) to test the effects of a gardening, nutrition, and cooking program in 375 low-income Hispanic students living in Los Angeles.
- Trial name
- NCT02668744
- Testing
- Intervention
- Where
- 16 sites in United States
- Volunteers
- 3,302 people, healthy volunteers welcome
- Sponsor
- Jaimie N. Davis
Type 2 Diabetes
Risk of CKD in Diabetic Patients With MAFLD
This cross-sectional study of 300 participants investigates the risk of chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes.
- Trial name
- NCT06304844
- Testing
- transient elastography (Fibroscan)
- Volunteers
- 300 people
- Sponsor
- Sohag University
Diabetes, Diabetes Mellitus, Type 1
Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes
The investigators are doing this study to see the effect of insulin degludec in pregnant women with type 1 diabetes, and if it is safe to use.
- Trial name
- EXPECT (NCT03377699)
- Testing
- Insulin degludec, Insulin Aspart, Insulin detemir
- Where
- 71 sites in Argentina, Australia and 13 more
- Volunteers
- 225 people
- Sponsor
- Novo Nordisk A/S
Rheumatoid Arthritis, Inflammation
Disulfiram in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation.
- Conditions
- Rheumatoid Arthritis, Inflammation, Obesity
- Trial name
- NCT07534332
- Testing
- Disulfiram (DSF)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
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