Clinical trials: Metabolic and Nutritional Disorders
Obesity, Abdominal
Efficacy of Electro-acupuncture for Abdominal Obesity: Study for a Randomized Controlled Trial
Electro-acupuncture provides stimulation to acupoints, and has been widely used to treat abdominal obesity in China despite of lack of high-level evidence for treatment efficacy.
- Trial name
- NCT04957134
- Testing
- Electro-acupuncture
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hubei Hospital of Traditional Chinese Medicine
Ischemic Stroke
hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase can play a role in preventing recurrent vascular events from ischemic heart disease patients, whose mechanism consists in not only the reduction of serum…
- Trial name
- NCT00361699
- Testing
- Statin
- Where
- 2 sites in Japan
- Volunteers
- 1,095 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Obesity, Abdominal
Impact of Preoperative Hypocaloric Hyperproteinic Lipid Restricting Diet on Bariatric Surgery
Obesity is one of the greatest pandemics of the 21st century with 30 million new cases each year. In France each year, 60,000 bariatric surgery procedures are performed.
- Trial name
- LipiDiet (NCT05529199)
- Where
- France
- Volunteers
- 776 people
- Sponsor
- University Hospital, Strasbourg, France
Diabetes Mellitus, Type 2, Insulin Resistance
Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old
Type 2 diabetes (T2DM) is characterized by hyperglycemia, insulin resistance, absolute or relative insulin deficiency, hyperglucagonemia, increased hepatic glucose production, frequently accelerated gastric emptying and obesity.
- Trial name
- NCT00843232
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Campinas, Brazil
Diabetic Neuropathies, Peripheral Nervous System Diseases
Effect of Physical Therapy in Improving the Health of Patients With Diabetic Peripheral Neuropathy
People with diabetes can have nerve damage in their extremities (peripheral neuropathy), and this can lead them to being less able to maintain their balance when they are standing, walking or performing complex movement tasks in…
- Trial name
- DPN-QoL (NCT02115932)
- Testing
- Strength & Balance Training
- Where
- Singapore
- Volunteers
- 143 people
- Sponsor
- National University Health System, Singapore
Diabetes Type 2
Safety Study of BMS-770767 in Subjects With Type 2 Diabetes
The purpose of this study is to determine if BMS-770767 is safe, well tolerated, measure its levels in the blood (pharmacokinetics), and measure the levels of chemicals (biomarkers) that may be affected by this drug…
- Trial name
- NCT01046422
- Testing
- BMS-770767, Metformin
- Where
- 18 sites in United States, Australia and 2 more
- Volunteers
- 76 people
- Sponsor
- Bristol-Myers Squibb
Cardiac Amyloidosis
Cardiac Amyloidosis Registry of University Hospital Leipzig
This is a clinical registry of patients with cardiac amyloidosis being treated at University Hospital Leipzig. The aim of the registry is to collect detailed information about clinical events, symptoms, imaging, biomarkers…
- Trial name
- NCT06129656
- Testing
- Routine diagnostics, Routine treatment
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Leipzig
Healthy, Obese
A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants
The main purpose of this study is to determine effect of orforglipron capsule formulation on the amount of digoxin, rosuvastatin, acetaminophen, midazolam, and simvastatin (each given alone and together with orforglipron) that…
- Conditions
- Healthy, Obese, Overweight
- Trial name
- NCT06186622
- Testing
- Orforglipron, Simvastatin, Digoxin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Child Malnutrition
Use of a 10 Points Visual Analogue Food Intake Scale for Children to Assess Intake: Prospective Study
In hospitalized children, undernutrition increases the length of hospitalization, aggravates the causal pathology, favors the occurrence of complications, and increases the cost of hospitalization.
- Trial name
- CESAR (NCT05726422)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Montpellier
Type I Diabetes
A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients With Type I Diabetes
The goal of the proposed pilot study is to determine whether glucose control can be improved with Bydureon treatment in patients with type I diabetes (T1D)
- Trial name
- NCT01928329
- Testing
- Exenatide (Bydureon®)
- Where
- 8 sites in United States
- Volunteers
- 79 people
- Sponsor
- Yale University
Disease Associated Underweight
Effects of Oral Nutrition Supplements in Children With Disease Associated Underweight
The purpose of this study is to test whether the provision of ONS to malnourished children across Europe, in addition to standard counselling, will improve weight gain and other outcomes.
- Trial name
- MIntS (NCT02383329)
- Testing
- The ONS provided to the children intervention group will be a ready to drink age adapted oral nutrition supplement providing 1,5 kcal/ml
- Where
- 19 sites in Belgium, Croatia and 7 more
- Volunteers
- 224 people
- Sponsor
- Dr. Michael Chourdakis
Diabetes
Continuous Monitoring and Control of Hypoglycemia
Evaluate safety of non-adjunctive CGM use in CGM naive participants.
- Trial name
- COACH (NCT03340831)
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- 25 sites in United States
- Volunteers
- 1,388 people
- Sponsor
- DexCom, Inc.
Diabetes
A Performance Evaluation of the Lumiradx Point of Care HbA1c Device
In patients who have diabetes, symptoms of diabetes or attending a diabetic clinic the study will evaluate agreement between the HbA1c measurements from the LumiraDx POC HbA1c assay and the Tosoh G8, as an aid in the monitoring…
- Trial name
- PHADE (NCT05403853)
- Testing
- Venepuncture, Fingerstick
- Where
- 4 sites in United Kingdom
- Volunteers
- 177 people
- Sponsor
- LumiraDx UK Limited
Malnutrition, Intestinal Diseases, Parasitic
The Effect of a Deworming Intervention to Improve Early Childhood Growth and Development in Resource-poor Areas
Worldwide, over 2 billion people suffer from worm infections in developing countries. These infections are especially damaging to the health of children, resulting in both short-term and lifelong disability.
- Trial name
- NCT01314937
- Testing
- Mebendazole, Usual care
- Where
- Peru
- Volunteers
- 1,760 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Kidney Diseases, Dialysis; Complications
PRevEnting FracturEs in REnal Disease - 1
PREFERRED-1 is a pilot study designed to determine the feasibility of a large randomized, pragmatic, open-label, comparative-effectiveness trial of denosumab for the prevention of fragility fractures in people receiving…
- Conditions
- Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder
- Trial name
- PREFERRED-1 (NCT05096195)
- Testing
- Denosumab 60 mg/ml, Calcium and vitamin D prophylaxis, Monitoring of post-injection calcium and phosphate
- Where
- 6 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Prader-Willi Syndrome
Stress and Brain Response Using MEG in PWS
Individuals with Prader-Willi Syndrome (PWS) have increased hunger and food seeking behaviour, as well as learning (cognitive) challenges.
- Trial name
- NCT04032639
- Where
- 2 sites in Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Type 2 Diabetes Mellitus
Safety and Efficacy of Autologous Adipose-Derived Stem Cell Transplantation in Type 2 Diabetics
The purpose of this study is to determine whether intravenous administration of autologous adipose-derived stem cells is of benefit in the management of types 2 diabetics.
- Trial name
- NCT00703612
- Testing
- Autologous Adipose-derived Stem cells
- Where
- 2 sites in Philippines
- Volunteers
- 34 people
- Sponsor
- Adistem Ltd
Obesity
Effect of LAPS-Exendin on Body Weight in Obese Population
The purpose of this study is to determine the optimal dose and regimen of HM11260C, in combination with a hypocaloric diet, to reduce weight in obese subjects who are otherwise considered in stable health.
- Trial name
- NCT02075281
- Testing
- HM11260C
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension
An Examination of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Patients With Type II Diabetes
This study will examine the ability of olmesartan medoxomil to lower the blood pressure of patients with Type II diabetes and high blood pressure.
- Trial name
- NCT00403481
- Testing
- olmesartan medoxomil, Olmesartan medoxomil plus Hydrochlorothiazide
- Where
- 27 sites in United States
- Volunteers
- 192 people
- Sponsor
- Daiichi Sankyo
Esophageal Motility Disorders
Esophageal Dysmotility and Dilatation After Laparoscopic Gastric Banding
The purpose of this study is to determine whether esophageal dysmotility and dilatation is an important complication in the long term follow-up following laparoscopic gastric banding for morbid obesity.
- Trial name
- NCT01234428
- Testing
- Laparoscopic surgery, gastric banding
- Where
- Switzerland
- Volunteers
- 167 people
- Sponsor
- Spital STS AG
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