Clinical trials: Metabolic and Nutritional Disorders
Cardiovascular Diseases, Atherosclerosis
Lipid Research Clinics Population Studies
To conduct epidemiologic surveys of the distribution, causes, and consequences of the dyslipoproteinemias. The Population Studies include the Prevalence Study, the Family Study, and the Mortality Follow-up Study and shared the…
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Coronary Disease, Heart Diseases
- Trial name
- NCT00005128
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anemia, Nutritional Deficiency
Anemia in Older Adults
A cross-sectional study with 829 older Mexican adults were recruited from July to September 2015, from four localities in the southern region of México.
- Conditions
- Anemia, Nutritional Deficiency, Inflammation
- Trial name
- NCT04820465
- Testing
- Non available due to cross-sectional study design
- Volunteers
- 829 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Diabetes Mellitus, Critical Illness
Degludec Insulin Use in Critically Ill Patients
Background: Dysglycemia in critically ill patients is common, where 40% to 54% of patients were found to be hyperglycemic on intensive care unit admission.
- Conditions
- Diabetes Mellitus, Critical Illness, Hyperglycemia
- Trial name
- NCT06056167
- Testing
- Degludec insulin
- Where
- Saudi Arabia
- Volunteers
- 155 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Obesity, Anxiety
Clusters in Obesity: Intuitive Eating and Mental Health Key for Personalisation
Objective: To determine clusters among weight-loss-seeking individuals for personalised obesity management and find questionnaires to help identify those who could benefit from psychological support.
- Conditions
- Obesity, Anxiety, Stress
- Trial name
- NCT06125600
- Testing
- Clustering of people living with obesity using behavioural questionnaires
- Where
- France
- Volunteers
- 989 people
- Sponsor
- University Hospital, Montpellier
Osteoporosis
Pharmacokinetics and Tolerability of Minodronic Acid and Food and Age Effects on the Pharmacokinetics
The primary objective of the the study was to evaluate the pharmacokinetic properties of minodronic acid tablets following single and multiple oral administration in healthy Chinese subjects.
- Trial name
- NCT02295436
- Testing
- minodronic acid
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Obesity
Effect and Safety of TCM-FMD in Phlegm-Dampness Type Overweight/Obesity Patients(EASTAR)
The primary aim of this study is to is to determine if a diet (TCM-FMD) which combine fasting-mimicking diet (FMD) with "dispelling dampness" meal replacement (a meal replacement made up of traditional Chinese medicine) is the…
- Trial name
- NCT04029571
- Testing
- TCM-FMD, FMD
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Renal Impairment, Diabetes
Pharmacokinetics of Vildagliptin in Mild, Moderate and Severe Renal Impaired Patients
This study assess the pharmacokinetics of vildagliptin in mild, moderate and severe renal impaired patients
- Trial name
- NCT00818571
- Testing
- Vildagliptin
- Where
- Russia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Gout
Food Effect Study of Febuxostat XR in Healthy Participants
The purpose of this study is to assess the effect of food on the bioavailability of febuxostat after a single oral dose of 80 mg febuxostat XR and to evaluate the pharmacokinetics (PK) of febuxostat after single oral doses of 40…
- Trial name
- NCT02374164
- Testing
- Febuxostat XR
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy Volunteers, Hypercholesterolaemia
A Research Study Investigating How NNC0385-0434 is Tolerated in People With or Without High Cholesterol Levels
In this study, there are two study medicines: NNC0385-0434 (the new medicine being tested) and placebo (a 'dummy' medicine). Participants will only get one of these medicines - which one is decided by chance.
- Trial name
- NCT04058834
- Testing
- NNC0385-0434
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
ALS, Amyotrophic Lateral Sclerosis
A Study to Explore the Role of Gut Flora in ALS
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding ALS
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Motor Neuron Disease
- Trial name
- NCT04150809
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Type 2 Diabetes
Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation
Type 2 diabetes is a chronic disease that has reached epidemic proportions. In order to improve our strategies for preventing and treating type 2 diabetes the investigators need to better understand the mechanism of this disease…
- Trial name
- NCT02198209
- Testing
- Liraglutide
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Type 2 Diabetes
A Study to Evaluate ITCA 650 Compared to Sitagliptin for the Treatment of Type 2 Diabetes
Phase 3 study to compare treatment with ITCA 650 to sitagliptin when added to metformin monotherapy in patients with type 2 diabetes.
- Trial name
- NCT01455909
- Testing
- ITCA 650 60 mcg/day, sitagliptin
- Where
- United States
- Sponsor
- Intarcia Therapeutics
Osteoporosis
Effectiveness of Smart-Video Based Game Therapy and Otago-Based Structured Exercises in Women With Osteoporosis
In this project, researchers evaluated the effects and differences of smart-video based game therapy and Otago-based structured exercises in women with osteoporosis; aimed to evaluate their applicability in women with…
- Trial name
- NCT06506409
- Testing
- Smart-Video Based Game Therapy, Otago Based Structured Exercise, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Medipol University
Hypertriglyceridemia
a Phase 1b/2a Study of JMT202 Injection in Participants With Hypertriglyceridemia
To evaluate the safety and tolerability of multiple subcutaneous injections of JMT202 injection in Chinese participants with hypertriglyceridemia
- Trial name
- phase Ib/Ⅱa st (NCT07140809)
- Testing
- JMT202 injection
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shanghai JMT-Bio Inc.
Obesity, Morbid
Duodenal-Ileal Diversion in Obese Patients Undergoing Primary Sleeve or Those With Inadequate Weight Loss After Sleeve
The objectives of this study are to assess the initial safety and device functionality of the SFM Anastomosis System including delivery systems when used to create a dual-path duodenal-ileal (D-I) diversion either during sleeve…
- Trial name
- NCT05064722
- Testing
- Self Forming Magnets (SFM)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- GI Windows, Inc.
Coronary Arterial Disease (CAD), Calcification; Heart
The Safety and Performence of ShockPulse-10 in Patients with Coronary Artery Calcification
This study is an exploratory, multicenter, single-group clinical trial aimed to evaluate the clinical outcomes of using ShockPulse-10 in the treatment of coronary artery calcification .
- Trial name
- NCT06711822
- Testing
- Shockplus-10
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Keya Medical
Type 1 Diabetes Mellitus
Randomized, Double-blind, Crossover, Pharmacokinetic (PK) and Glucodynamic (GD) Study of Continuous Subcutaneous Insulin Infusion (CSII) in Participants With Type 1 Diabetes Mellitus (T1DM)
The purpose of this study is to determine if recombinant human hyaluronidase PH20 (rHuPH20) will change the exposure and action of approved insulin analogs when given by continuous subcutaneous insulin infusion (CSII) in…
- Trial name
- NCT01275131
- Testing
- Insulin aspart, Recombinant human hyaluronidase PH20 (rHuPH20)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Halozyme Therapeutics
Obesity
Phase 2a Obesity Study of Oral Doses of Oleoyl-Estrone (MP-101)
The purpose of this study is to evaluate the safety, preliminary efficacy, and pharmacokinetics of two 14-day cycles of escalating oral doses of MP 101 in 100 obese adult subjects.
- Trial name
- NCT00449202
- Testing
- oleoyl-estrone (MP 101)
- Where
- 3 sites in United States, Switzerland
- Volunteers
- 100 people
- Sponsor
- Manhattan Pharmaceuticals
Prediabetes
The Prevalence of Metabolic Syndrome and Its Associated Factors in an Urban City
The secondary objective is to evaluate the agreement between these criteria and the prevalence of concordant and discordant according to different criteria.
- Trial name
- NCT00308672
- Where
- Taiwan
- Volunteers
- 3,000 people
- Sponsor
- China Medical University Hospital
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