Clinical trials: Metabolic and Nutritional Disorders
Heart Failure With Reduced Ejection Fraction, Iron Deficiency
The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life(COREVIVE-HFrEF)
This study will address whether the additional use of Ferric Derisomaltose on top of standard care will improve exercise capacity and quality of life in patients with acute heart failure and iron deficiency.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Iron Deficiency, Acute Heart Failure
- Trial name
- COREVIVE-HFrEF (NCT05971732)
- Testing
- Ferric derisomaltose
- Where
- China
- Volunteers
- 146 people
- Sponsor
- China-Japan Friendship Hospital
Pompe Disease (Late-onset)
Evaluation of the Safety, Tolerability and Efficacy of Gene Therapy Drug for Late Onset Pompe Disease (LOPD)
This is a single-center, single-arm, open-label, single-dose treatment clinical study to evaluate the safety, tolerability and efficacy of CRG003 injection in participants with late onset Pompe disease (LOPD), with a long-term…
- Trial name
- NCT06178432
- Testing
- CRG003 injection
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Huashan Hospital
Multimorbidity, Comorbidity
A Study on the Effectiveness of Comprehensive Intervention Based on Specialized Physical Education Courses in the Prevention of Comorbidity Among Junior Middle School Students
Junior high school students are in a critical period of physical and mental development, currently facing two major health challenges: first, persistently high rates of myopia with a noticeable trend toward younger onset; second…
- Conditions
- Multimorbidity, Comorbidity, Common Diseases in Children and Adolescents, Myopia
- Trial name
- NCT07237698
- Testing
- The intervention group participated in specialized physical education courses.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xiaoyan Wu
Childhood Obesity
Mountain West Prevention Research Center Core Research Project
This hybrid type 3 effectiveness-implementation sequential multiple assignment randomized trial will assess the impact of integrating population health management (PHM) strategies-text messaging and enrollment in Building Healthy…
- Trial name
- MW-PRCCRP (NCT07479498)
- Testing
- Text Message-based recruitment, Active outreach follow-up
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Paul Estabrooks
Overweight, Cardiovascular Diseases
Dietary Fat and High-Density Lipoprotein (HDL) Metabolism-Effect of Carbohydrate and Fat Intake
Generally, people with low levels of high-density lipoprotein (HDL) in blood are more likely to get heart disease than those who have normal or high levels.
- Trial name
- NCT01399632
- Testing
- Low Fat and High Carbohydrate Diet, High Fat and Low Carbohydrate Diet
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Osteoporosis, Osteopenia
Finding the Optimal Resistance Training Intensity For Your Bones
Osteoporosis is a bone disease that can result in fractures, disability and an increased risk of premature death. Exercise is recommended for fall and fracture prevention, but health care professionals often recommend walking or…
- Trial name
- NCT05541432
- Testing
- Supervised strength training (group 1), Supervised strength training (group 2), Home exercise
- Where
- 3 sites in Canada
- Volunteers
- 324 people
- Sponsor
- University of Waterloo
Diabetes, Diabetes Mellitus, Type 1
Comparison of NN1250 Versus Insulin Detemir, Both Combined With Insulin Aspart in Subjects With Type 1 Diabetes
This trial is conducted in Japan. The aim of this clinical trial is to investigate the safety (with emphasis on hypoglycaemia) after switching from long-acting insulin analogue or intermediate-acting insulin to insulin degludec…
- Trial name
- NCT00841087
- Testing
- insulin degludec, insulin detemir, insulin aspart
- Where
- 8 sites in Japan
- Volunteers
- 65 people
- Sponsor
- Novo Nordisk A/S
PCOS, Infertility
Glucose Metabolism and Live Birth Outcomes in PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine and reproductive disorder in which insulin resistance (IR) is proposed as a key pathophysiological feature of the disease's symptoms and consequences.
- Conditions
- PCOS, Infertility, Diabetes, PreDiabetes
- Trial name
- NCT04364087
- Testing
- Oral glucose tolerance test
- Where
- Vietnam
- Volunteers
- 1,208 people
- Sponsor
- Mỹ Đức Hospital
Diabetes Mellitus, Type 1
Clinical Study to Evaluate the Bio-Psychosocial Impact of Mobile App for Diabetes Type 1 ("SOCIAL DIABETES")
Based on international recommendations, the current clinical research project considers the effectiveness of a free diabetes app with a CE (Conformité Européenne) mark, "Social Diabetes", which incorporates the addition of a…
- Trial name
- NCT03455816
- Testing
- Social Diabetes App, Usual clinical monitoring group (Control group)
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Soledad Ruiz de Adana
Diabetes Mellitus, Fat; Intolerance, Pancreas
Effect of Empagliflozin on Body Composition and Ketones
The purpose of this study is to evaluate changes of body composition induced by Sodium-glucose cotransporter-2 (SGLT2) inhibitor and its metabolic consequence in Korean type 2 diabetes (T2D).
- Trial name
- NCT03877406
- Testing
- Empagliflozin 10 MG, Hypoglycemics Oral
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Bundang Hospital
Search MeSH
Developing and Validating Clinical Efficacy for Obesity Digital CBT Model
The aim of the present study is to develop and validate the effects of a new cognitive behavioral therapy (CBT) using digital healthcare mobile apps such as Noom Coach and InBody.
- Trial name
- NCT03465306
- Testing
- Cognitive Behavioral Therapy, Self-guided
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hypertension, Abdominal Obesity
Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With Hypertension
Part 1 determined: aliskiren, amlodipine and angiotensin II concentrations in interstitial fluid of fat and skeletal muscle; aliskiren and angiotensin II concentrations, and renin activity and concentration in fat and skeletal…
- Trial name
- NCT00498433
- Testing
- Aliskiren, Amlodipine
- Where
- 2 sites in Germany
- Volunteers
- 46 people
- Sponsor
- Novartis
Hypertriglyceridemia, Metabolic Syndrome
Study to Assess Tricor Therapy Effectiveness in Patients With Metabolic Syndrome (TRISTAN)
This study is a prospective observational program within the frames of which Tricor (fenofibrate) is prescribed to patients with hypertriglyceridemia within a routine procedure as a part of the combination therapy with statins.
- Trial name
- TRISTAN (NCT04650152)
- Testing
- Tricor (fenofibrate), 145 mg, film-coated tablet
- Where
- 63 sites in Russia
- Volunteers
- 1,000 people
- Sponsor
- Abbott
Obesity, Gestational Diabetes
Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial
The purpose of this study is to verify if postprandial walks are effective in obese pregnant women, as regards to gestational weight gain and typical diseases of that period, as gestational diabetes and preeclampsia.
- Conditions
- Obesity, Gestational Diabetes, Preeclampsia
- Trial name
- NCT02180152
- Testing
- Postprandial walks
- Where
- Brazil
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Diabetes Mellitus Type 2, Hypercholesterolemia
Effect of Ezetimibe or Simvastatin or Both on Low Densitiy Lipoprotein -Subfractions in Patients With Type 2 Diabetes
It is of interest how ezetimibe alone or in combination with statin may influence atherogenic dense Low Density Lipoprotein (dLDL) in patients with type 2 diabetes mellitus.
- Trial name
- EZE (NCT01384058)
- Testing
- ezetimibe, simvastatin, Ezetimibe 10/Simvastatin 20
- Where
- 2 sites in Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Healthy Volunteers
Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway
The purpose of this study was to determine if airway pH has an effect on albuterol-induced vasodilation in the airway. Methods: Ten healthy volunteers performed the following respiratory maneuvers: quiet breathing, hypocapnic…
- Trial name
- NCT01216748
- Testing
- quiet breathing, Hypocapnic Hyperventilation, Hypercapnic Hyperventilation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Miami
Diabetes Mellitus, Type 2
C-Reactive Protein (CRP) in Obese Diabetic Women
The purpose of this study is to determine whether treatment with rosuvastatin for 6 months in obese type 2 diabetic women will improve their lipid profiles and thus prevent the progression to cardiovascular disease.
- Trial name
- NCT00262548
- Testing
- Rosuvastatin; improvement of lipid profile
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Body Composition
Effect of Cinnamon Powder Capsules on Body Composition
Obesity is a global health concern that significantly affects individuals, and its prevalence is still rising at an alarming rate. While various treatments are available, they often come with unwanted side effects.
- Trial name
- NCT06119555
- Testing
- Cinnamon Capsules
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Iron Deficiency Anemia
Intravenous Ferric Carboxymaltose vs IV Iron Sucrose or IV Iron Dextran in Treating Iron Deficiency Anemia in Women
The purpose of this study is to compare safety and the oxidative stress potential of two doses of an investigational IV iron, ferric carboxymaltose (FCM), compared to an equal single dose of IV iron sucrose or IV iron dextran in…
- Trial name
- NCT01290315
- Testing
- Ferric Carboxymaltose (FCM), Iron Sucrose / Iron Dextran
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- American Regent, Inc.
Tuberculosis, Diabetes Mellitus
Tuberculosis Drug Levels and Continuous Glucose Monitoring in Diabetic Patients
Diabetes significantly increases the risk of developing active tuberculosis (TB). Diabetic patients who do develop TB have worse treatment outcomes and overall mortality.
- Trial name
- NCT05329415
- Testing
- TB Drug Levels
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- London North West Healthcare NHS Trust
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