Clinical trials: Metabolic and Nutritional Disorders
Bariatric Surgery Candidate, Lifestyle
Direct Measurement of Food Intake Behaviour in Obese Women Before and After Bariatric Surgery or Lifestyle Intervention
To assess changes in food intake and food preference (e.g., fat and sugar) after bariatric surgery and lifestyle intervention alone with a direct measurement.
- Conditions
- Bariatric Surgery Candidate, Lifestyle, Obesity
- Trial name
- CIBuS (NCT04990947)
- Testing
- lifestyle / RYGB
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Rijnstate Hospital
Type 2 Diabetes
AI Ready and Exploratory Atlas for Diabetes Insights
The study will collect a cross-sectional dataset of 4000 people across the US from diverse racial/ethnic groups who are either 1) healthy, or 2) belong in one of the three stages of diabetes severity (pre-diabetes/diet…
- Trial name
- AI-READI (NCT06002048)
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Washington
Mitochondrial Diseases, Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
The KHENEREXT Study
This is an open-label, multi-centre study in subjects with a genetically confirmed mitochondrial deoxyribonucleic acid (DNA) transfer ribonucleic acid (tRNA)Leu(UUR) m.3243A>G mutation who completed study KH176-202.
- Conditions
- Mitochondrial Diseases, Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation, Maternally Inherited Diabetes and Deafness (MIDD), Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS)
- Trial name
- NCT04604548
- Testing
- Oral administration of 100 mg KH176 twice daily
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 11 people
- Sponsor
- Khondrion BV
Type 1 Diabetes
Low cArbohydraTe dIeT and aUtomated Insulin Delivery System for Type 1 DiabetEs
This is a randomized, controlled study in people living with type 1 diabetes using an automated insulin delivery (AID) system. Participants will be assigned to a control diet (45% carbohydrate) or a low carb diet (25%…
- Trial name
- LATITUDE (NCT05449678)
- Testing
- Low-carb diet
- Volunteers
- 38 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Pregnancy, Gestational Diabetes
Fructosamines and Gestational Diabetes (FRUCTO)
The prevalence of gestational diabetes is estimated at between 2 and 6%, but can be much higher in specific populations. The specific treatment of gestational diabetes (diet, control weight gain, self monitoring glucose , insulin…
- Trial name
- FRUCTO (NCT02159378)
- Testing
- Fructosamines
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Obesity
A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose Weight
This study is open to adults who are at least 18 years old and have a body mass index (BMI) of 30 kg/m² or more, or a BMI of 27 kg/m² or more and at least one health problem related to their weight.
- Trial name
- SYNCHRONIZE™-1 (NCT06066515)
- Testing
- survodutide
- Where
- 118 sites in United States, Australia and 12 more
- Volunteers
- 726 people
- Sponsor
- Boehringer Ingelheim
Depressive Disorder, Major, Metabolic Syndrome X
Pioglitazone for the Treatment of Major Depressive Disorder Comorbid With Metabolic Syndrome
The goal of this study is to begin to test whether or not pioglitazone, an FDA approved medication used to treat high blood sugar, may be safe and effective in treating Major Depressive Disorder (MDD) in patients with comorbid…
- Trial name
- NCT00671515
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Joseph Calabrese, MD
Type 1 Diabetes, C-peptide
C-peptide Correlation With Microvascular Complications in T1DM
The purpose of this study is to investigate the presence of residual insulin secretion in patients with DM1 and its correlation with the possible protection against early microvascular and macrovascular complications, emphasizing…
- Conditions
- Type 1 Diabetes, C-peptide, Diabetes Complications
- Trial name
- NCT04474535
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Friedreich Ataxia
Safety Study of Idebenone to Treat Friedreich's Ataxia
This study will determine the highest dose of idebonone that can safely be given to patients with Friedrich's ataxia, an inherited degenerative disease that causes loss of muscle coordination, speech problems, weakness and…
- Trial name
- NCT00015808
- Testing
- Idebenone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Gaucher Disease, Type 1
Phase III Study of ISU302 in Patients With Type 1 Gaucher Disease
The purpose of this study is to evaluate the safety and efficacy of ISU302 in patients with Type 1 Gaucher disease.
- Trial name
- NCT02770625
- Testing
- ISU302
- Volunteers
- 8 people
- Sponsor
- ISU Abxis Co., Ltd.
Diabetes, Diabetes Mellitus, Type 1
The Impact of Initiating/Switching to Insulin Detemir on Emotional Well-being and Treatment Satisfaction
This study is conducted in Europe. The aim of this study is to assess the well-being of patients following treatment with insulin detemir (Levemir®) in subjects with type 1 or type 2 diabetes in whom either initiation of or a…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- CONFIDENCE (NCT01542476)
- Testing
- insulin detemir
- Where
- Netherlands
- Volunteers
- 299 people
- Sponsor
- Novo Nordisk A/S
Osteoporosis, Postmenopausal, Osteoporosis, Age-Related
Tart Cherry Supplementation and Women's Bone Health Study
In spite of aggressive approaches to prevent and treat osteoporosis, it remains one of the most costly and debilitating diseases associated with aging.
- Trial name
- NCT04167150
- Testing
- tart cherry juice concentrate is a commercial product provided by King Orchards (Central Lake, MI)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Metabolism Disorder, Glucose, Physical Activity
Aerobic Treadmill Exercise And Metabolism
Overview- In this study, overweight or obese, sedentary participants (age=35-55 years, n=20) will be randomized to a 12-week control period or an aerobic exercise intervention.
- Conditions
- Metabolism Disorder, Glucose, Physical Activity, Sedentary Lifestyle
- Trial name
- The A-TEAM (NCT03162991)
- Testing
- Aerobic Exercise Intervention
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Childhood Obesity
Kindergarten-based Intervention for Childhood Obesity in Guangzhou(KICOG)
Early life interventions for childhood obesity may provide substantial benefits. Most existing studies aimed at school children have reported limited effectiveness, however few have targeted preschool children.
- Trial name
- KICOG (NCT03022474)
- Testing
- Healthy Lifestyles Intervention
- Volunteers
- 984 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Minimal Hepatic Encephalopathy
Probiotic Lactobacillus GG (LGG) in Patients With Minimal Hepatic Encephalopathy
This research proposes to find whether the probiotic lactobacillus GG is safe and well tolerated in patients with minimal hepatic encephalopathy. We also want to get insight into the mechanisms of action of LGG.
- Trial name
- NCT00992290
- Testing
- Lactobacillus GG
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Virginia Commonwealth University
Diabetes, Type 1
Hybrid Closed-Loop Insulin Delivery System in Type 1 Diabetes Candidates for a Living Donor Kidney Transplant
The investigators' primary aim is to determine the impact of using hybrid closed-loop (HCL) system in patients with type 1 diabetes (T1D) and end stage renal disease (ESRD) prior to kidney transplantation.
- Trial name
- NCT03494010
- Testing
- Observation
- Where
- United States
- Sponsor
- Yale University
Diabete Type 2
Assessment of Personalized Follow-up in Prevention of Type 2 Diabetes
In France, the overall prevalence of diabetes was estimated at 5% of population in 2016, type 2 diabetes (T2DM) corresponding to 90% of cases.
- Trial name
- Proxipart (NCT05325710)
- Testing
- Study nurse intervention
- Where
- France
- Volunteers
- 230 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Erectile Disfunction, Coronary Artery Disease (CAD)
"Erectile Function After PCI in MI and Non-MI Patients"
The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6…
- Conditions
- Erectile Disfunction, Coronary Artery Disease (CAD), Diabete Mellitus, Anxiety
- Trial name
- ERECT-PCI (NCT07444697)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Lipodystrophy
Carotid Doppler Peak Velocity Variation in Liposuction Fluid Management
This study aims to compare the hemodynamic parameters, postoperative plethysmography variability index, the total amount of postoperative intravenous fluid administration needed, and the urine output of two methods of fluid…
- Trial name
- NCT05930106
- Testing
- Intraoperative fluid ratio, Carotid Artery Doppler Peak Velocity Variation
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TJ Plast Advanced Center for Plastic Surgery
Type 2 Diabetes Mellitus (T2DM), Hyperglycemia
Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Hyperglycemia, Metabolic Syndrome, Older Adults (65 Years and Older)
- Trial name
- EFIR (NCT07574333)
- Testing
- Intermittent Hypoxic-Hyperoxic Training (3 days), Intermittent Hypoxic-Hyperoxic Training (10 days), Normoxic gas breathing
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
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