Clinical trials: Metabolic and Nutritional Disorders
Obesity, Diabetes
Semaglutide 2.4 mg in Patients With Poor Weight-loss
A double-blinded, randomised, placebo-controlled trial of semaglutide 3.0 mg/ml in patients with poor weight-loss following bariatric surgery.
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- BARI-STEP (NCT05073835)
- Testing
- Semaglutide 3 mg
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Diabetes, Hypertension
Genetics of Type 2 Diabetes Among Han Chinese
Objectives: To conduct a genome-wide association study (GWAS) to identify susceptibility genetic variants for diabetes among Han Chinese.
- Trial name
- NCT00837408
- Where
- China
- Volunteers
- 2,379 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Leukemia, Lymphoma
Effect of Tight Control of Blood Glucose During Hyper-CVAD Chemotherapy For Acute Lymphocytic Leukemia (ALL)
The goal of this clinical research study is to learn if intense management and control of blood sugar levels during treatment for acute lymphocytic leukemia, Burkitts lymphoma, or lymphoblastic lymphoma will result in decreased…
- Trial name
- NCT00500240
- Testing
- Insulin Glargine, Insulin Aspart
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy Lifestyle, Health Behavior
Better App: (Further-)Development and Evaluation of a Digital Lifestyle Programme
In recent years, we developed and evaluated personalised lifestyle interventions, the BETTER programmes (BETER in Dutch, acronym for Move, Eat, Change).
- Trial name
- BETTERapp (NCT05837468)
- Testing
- BETTERapp
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Zuyd University of Applied Sciences
Mitochondrial Diseases, Developmental Delay Disorder
Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental Disorders
Background: Small-Fiber-Neuropathy describes the degeneration of mildly or unmyelinated nerve fibers and causes neuropathic pain and autonomic dysfunction.
- Conditions
- Mitochondrial Diseases, Developmental Delay Disorder, Small Fiber Neuropathy, Cerebral Palsy
- Trial name
- SFN_children (NCT05645874)
- Testing
- Skin biopsy
- Where
- Germany
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Diabetes Mellitus, Type 1
Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes Mellitus.
testing of autonomic function and relationship with exercise and Qol in diabetic patients and controls
- Trial name
- NCT03481374
- Testing
- autonomic function testing
- Where
- Belgium
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Obstructive Sleep Apnea, Metabolic Syndrome
Effects of CPAP on Cardiovascular Risk in Obstructive Sleep Apnea (OSA) and Metabolic Syndrome
The increased risk of atherosclerotic morbidity and mortality in patients with obstructive sleep apnea (OSA) has been linked to arterial hypertension, insulin resistance, systemic inflammation, and oxidative stress in previous…
- Trial name
- NCT00635674
- Testing
- CPAP device - REMstar Plus, Respironics, Murrysville, USA
- Where
- Slovakia
- Volunteers
- 32 people
- Sponsor
- Pavol Jozef Safarik University
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Depression, Obesity
Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women
This study will compare the effectiveness of two weight loss programs, one supplemented with health education and the other supplemented with behavioral counseling, in treating women who are depressed and overweight.
- Trial name
- NCT00572520
- Testing
- Weight loss treatment, Behavior therapy for depression, Health education counseling
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- University of Massachusetts, Worcester
Alkaptonuria
Suitability of Nitisinone in Alkaptonuria 2
This is a proposal to develop the orphan designated drug, nitisinone, for the treatment of a rare Mendelian disease, Alkaptonuria (AKU).
- Trial name
- SONIA 2 (NCT01916382)
- Testing
- Nitisinone
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Liverpool
Type 2 Diabetes
GLucobay M OBservation Study for Efficacy and Safety in Treatment of Type-2 Diabetes Patients
An observational and multicenter study to assess the effectiveness and safety of Glucobay®- M under daily life treatment of type-2 diabetes patients.The study objectives are to investigate the effectiveness and safety of…
- Trial name
- GLOBE (NCT01219582)
- Testing
- Glucobay M (Acarbose/Metformin, BAY81-9783)
- Where
- India
- Volunteers
- 9,364 people
- Sponsor
- Bayer
Obesity, Bariatric Surgery
Comparison of Epidural and Intravenous Analgesia in Laparoscopic Sleeve Gastrectomy Patients
This retrospective observational study aimed to compare the effects of epidural analgesia and intravenous analgesia on early postoperative pulmonary function in patients undergoing laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy
- Trial name
- EAvs IV in LSG (NCT07712224)
- Testing
- Epidural analgesia (0.125% bupivacaine/2mcg fentanyl solution), Intravenous analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Type 2 Diabetes Mellitus
Efficacy and Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of Canagliflozin (TA-7284) in combination with Insulin in patients with type 2 Diabetes for 16 weeks administration.
- Trial name
- NCT02220920
- Testing
- Canagliflozin (TA-7284), Insulin
- Where
- 7 sites in Japan
- Volunteers
- 146 people
- Sponsor
- Tanabe Pharma Corporation
Type 2 Diabetes Mellitus
Prediction of Findings From the Ongoing CAROLINA Trial Using Healthcare Database Analyses
This cohort study was initiated to predict the findings of CAROLINA trial in a real world setting using electronic claims data from insurance databases with results anticipated prior to the completion of CAROLINA.
- Trial name
- NCT03648424
- Where
- United States
- Volunteers
- 48,262 people
- Sponsor
- Brigham and Women's Hospital
Diabetic Foot, Diabetes
Predictors of Skin Temperature, Plantar Pressure and Ulceration in Diabetic Foot Patients.
Diabetes is a chronic disease with increasing prevalence worldwide with a high burden to individuals and the society and it is expected to be the 7th leading cause of death in 2030.
- Trial name
- NCT03254095
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Hypercholesterolemia
Effects of Vytorin Versus Placebo in Subjects With Primary Hypercholesterolemia (Study P04420)
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 3 study of Vytorin 10/10 (ezetimibe 10 mg with simvastatin 10 mg), Vytorin 10/20 (ezetimibe 10 mg with simvastatin 20 mg), and Vytorin…
- Trial name
- NCT00413972
- Testing
- ezetimibe with simvastatin
- Volunteers
- 392 people
- Sponsor
- Organon and Co
Radiocontrast-Induced Nephropathy, Chronic Kidney Disease
Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease
Contrast-induced nephropathy (CIN) is the third most common cause of hospital acquired acute kidney injury, accounting for 10% of all cases. The pathophysiology of CIN is unclear. Possible mechanisms involve 1.
- Conditions
- Radiocontrast-Induced Nephropathy, Chronic Kidney Disease, Diabetes Mellitus
- Trial name
- NCT00808795
- Testing
- N-acetylcysteine
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
Type 2 Diabetes
The Diabetes Aerobic and Resistance Bands Exercise (DARE-Bands) Trial
BACKGROUND Resistance exercise training with free weights or weight machines clearly improves glucose (sugar) control in type 2 diabetes (T2D).
- Trial name
- DARE-Bands (NCT02009995)
- Testing
- Aerobic Training (AT), AT plus Primarily Home-Based Resistance Band Training
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University of Calgary
Postpartum Anemia Nos, Iron-deficiency
Intravenous Iron Carboxymaltose, Isomaltoside and Oral Iron Sulphate for Postpartum Anemia
Anemia affects between 20 and 50 % of women in the postpartum period. It is associated with several adverse health consequences, such as impaired physical work capacity, deficits in cognitive function and mood, reduced immune…
- Trial name
- NCT03957057
- Testing
- Iron Carboxymaltose, Iron Isomaltoside, Ferrous sulphate
- Where
- Slovenia
- Volunteers
- 300 people
- Sponsor
- University Medical Centre Ljubljana
Morbid Obesity, Severe Obesity
Trial Assessing the Immunogenicity and Safety of Two Influenza Vaccine Strategies Among Severe Obese Adult Patients
Obesity has been considered as a risk factor for mortality and development of complications during infection with the influenza virus.
- Trial name
- FLUO (NCT05409612)
- Testing
- Supemtek®, Vaxigriptetra®
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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