Clinical trials: Metabolic and Nutritional Disorders
Type 2 Diabetes, Hypertension
Impact of Clinical Pharmacist-Led Intervention on Management of Diabetic Hypertensive Patients in Eastern Nepal
Diabetic-Hypertensives are at a higher risk of premature microvascular and macrovascular complications than diabetes alone. Proper lifestyle management, diet, disease monitoring, and medication adherence is essential in achieving…
- Trial name
- NCT05707481
- Testing
- Clinical Pharmacist-Led Educational Intervention
- Where
- Nepal
- Volunteers
- 92 people
- Sponsor
- Chettinad Academy of Research and Education (Deemed to be University)
PreDiabetes
Efficacy and Safety of Digital Therapeutic in Adults With Prediabetes
The study aims to evaluate the efficacy and safety of a digital therapeutic (TH-001) for adult individuals with prediabetes.
- Trial name
- NCT05668819
- Testing
- TH-001
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Tesu Saglik Teknolojileri A.S.
Type 2 Diabetes
Safety Study of Mesenchymal Precursor Cells in Type 2 Diabetes
This study is being conducted to assess the overall safety and tolerability of a single intravenous infusion of three doses of Mesenchymal Precursor Cells versus Placebo in subjects with Type 2 Diabetes inadequately controlled on…
- Trial name
- NCT01576328
- Testing
- Mesenchymal Precursor Cells (MPCs)
- Where
- 18 sites in United States
- Volunteers
- 61 people
- Sponsor
- Mesoblast, Ltd.
Osteoporosis, Osteopenia
Does Treatment of Hypovitaminosis D Increase Calcium Absorption?
The purpose is to perform a one-year study designed to assess whether treatment of hypovitaminosis D increases intestinal absorption of calcium, subsequent retention of calcium within bone, decreases bone turnover, and favorably…
- Conditions
- Osteoporosis, Osteopenia, Vitamin D Deficiency, Hypoparathyroidism
- Trial name
- NCT00581828
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Clinical Evaluation of BD NEXT Pen Needle
This prospective, multi-center, 2 period cross-over study is designed to determine if people who use injection pens for subcutaneous medication delivery prefer the BD NEXT pen needle (PN) in comparison with currently marketed pen…
- Trial name
- NCT01852136
- Testing
- BD NEXT 31G x 5 mm pen needle, BD NEXT 31G x 8mm pen needle, BD NEXT 32G x 4mm pen needle
- Where
- 5 sites in United States, Canada
- Volunteers
- 217 people
- Sponsor
- Becton, Dickinson and Company
Dyslipidemia
A Long-term Study of ERN/LRPT (Extended Release Niacin/Laropiprant [MK0524A]) in Patients With Dyslipidemia (0524A-102)
This study will evaluate the efficacy of laropiprant (LRPT) to reduce flushing symptoms beyond 6 months and will measure the impact of withdrawal of laropiprant in patients following 20 weeks of stable maintenance therapy.
- Trial name
- NCT00961636
- Testing
- ER niacin (+) laropiprant (ERN/LRPT), Extended-release niacin (ERN)
- Volunteers
- 1,152 people
- Sponsor
- Merck Sharp & Dohme LLC
Arterial Hypertension, Menopause
Blood Pressure and Cardiometabolic Risk (Diet-to-HTN)
Obesity is a significant health issue that increases the risk of serious cardiovascular problems. In recent years, two dietary methods, the Ketogenic Diet (KD) and Intermittent Fasting (IF), have become popular for their…
- Conditions
- Arterial Hypertension, Menopause, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT06457711
- Testing
- Free diet Group (FDG), Very low Calorie Ketogenic Diet Group (VLCKDG), Intermittent Fasting Group (IFG)
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Diabetes Mellitus
Studying the Effectiveness of Non-Invasive Glucose Sensors in Patients With Diabetes: The SENSOR Study
The overall goal for this pilot clinical trial is to explore the accuracy and acceptability of a non-invasive, wearable glucose sensor in patients living with DM.
- Trial name
- SENSOR (NCT02800044)
- Testing
- Wearing a non-invasive glucose sensor
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Diego
Hypoglycemia, Inflammatory Response
Consequences of Hypoglycaemia on Cardiovascular and Inflammatory Responses
People with Type 1 diabetes (T1DM), type 2 diabetes (T2DM) and healthy volunteers will undergo a hypoglycaemic clamp to to investigate the effect of hypoglycaemia on cardiovascular and inflammatory responses.
- Conditions
- Hypoglycemia, Inflammatory Response, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- HCIR (NCT03976271)
- Testing
- hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Metabolic Syndrome
A Clinical Study to Evaluate the Safety and Tolerability of BioPB-01 in Healthy Adults
The present study is a randomized, placebo-controlled, parallel-group, double-blind clinical study. Seventy-eight individuals will be screened, and considering a screening failure rate of 20%, approximately 64 participants will…
- Trial name
- NCT05839444
- Testing
- BioPB-01
- Where
- 2 sites in India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus (T1DM)
Pediatric Insulin Plan Calculator for T1DM Management
This is a multi-centre, prospective, randomized, open-label controlled trial designed to evaluate the effectiveness of a flexible digital insulin dose calculator in children under 12 years of age with Type 1 Diabetes Mellitus…
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus (T1DM), T1DM, T1DM - Type 1 Diabetes Mellitus
- Trial name
- FLEXI-T1D (NCT07427134)
- Testing
- Flexible Digital Insulin Dose Calculator
- Where
- 2 sites in Iraq, Pakistan
- Volunteers
- 440 people
- Sponsor
- Sultan Qaboos University
Diabetes Mellitus, Type 1, Eating Disorders
Safe Management of People With Type 1 Diabetes and EAting Disorders studY
There is currently no effective intervention for type 1 diabetes and eating disorders. The main objective of STEADY Stage 2 is to test the feasibility of the newly developed STEADY intervention.
- Trial name
- STEADY-II (NCT05140564)
- Testing
- STEADY intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Hepatitis
Treating Nonalcoholic Steatohepatitis With Pioglitazone
Nonalcoholic steatohepatitis (NASH) is a common liver disease that resembles alcoholic hepatitis but occurs in persons who drink little or no alcohol.
- Trial name
- NCT00062764
- Testing
- Actos (Pioglitazone)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hyperlipidemia, Diabetes Mellitus
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Metabolic Syndrome, Arterial Hypertension
- Trial name
- NCT01571609
- Testing
- first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Interactions Between Neurostimulation and Physical Exercise
People with cervical spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) have reduced connections in the nerve circuits between the brain and the hands.
- Trial name
- NCT03076632
- Testing
- Cervical plus transcranial stimulation, Cervical stimulation plus hand/wrist exercise, Electromyographic (EMG)-triggered (closed-loop) stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Osteoporosis, Osteopenia or Osteoporosis
Assessment of Cortical Bone Mechanics Technology (CBMT) Fracture Discrimination Capability
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility (i.e., weakness) and an increased risk for fracture.
- Conditions
- Osteoporosis, Osteopenia or Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Risk
- Trial name
- STRONGER (NCT05721898)
- Testing
- Cortical Bone Mechanics Technology
- Where
- 5 sites in United States
- Volunteers
- 394 people
- Sponsor
- Ohio University
Anemia, Iron-Deficiency
Epidemiological Study of Iron Deficiency and Iron Deficiency Anemia in Chinese Pregnant Women
The purpose of this study is to know the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) among pregnant women in Chinese urban district at present, and to analyze the epidemiological characteristics of ID/IDA…
- Trial name
- EIDACPW (NCT02887963)
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- West China Hospital
Obesity, Type 2 Diabetes Mellitus
Safety and Effectiveness of Tirzepatide in Patients With Obesity at Hospital de Clínicas, Paraguay
This is a Phase 4 observational study evaluating the safety and effectiveness of tirzepatide (T.G.) manufactured by INDUFAR S.A.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Overweight With Comorbidities
- Trial name
- NCT07492563
- Testing
- Tirzepatide (T.G.)
- Where
- Paraguay
- Volunteers
- 300 people
- Sponsor
- LABORATORIOS INDUFAR
Type 2 Diabetes Mellitus
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy of the study drug tirzepatide in participants with type 2 diabetes mellitus.
- Trial name
- NCT03131687
- Testing
- tirzepatide, Dulaglutide
- Where
- 49 sites in United States, Poland and 2 more
- Volunteers
- 318 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Diabetic Nephropathy
Role of Triglyceride-Glucose Index and Inflammatory Biomarkers as Prognostic Tools for Progression of Diabetic Nephropathy
This study aims to evaluate the prognostic value of the Triglyceride-Glucose (TyG) index alongside inflammatory biomarkers in predicting the progression of diabetic nephropathy, exploring their correlation with disease severity…
- Trial name
- NCT07813793
- Volunteers
- 105 people
- Sponsor
- Assiut University
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