Clinical trials: Metabolic and Nutritional Disorders
Acute Malnutrition, Severe, Malnutrition, Child
Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia
The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment…
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06380504)
- Testing
- R-SWITCH integrated intervention package
- Where
- Ethiopia
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Obesity
Adipokines in Obese Adolescents With Insulin Resistance
The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after…
- Trial name
- NCT01410604
- Testing
- Metformin
- Where
- 2 sites in Mexico
- Volunteers
- 31 people
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Pharmacokinetic Properties of FIAsp in Children, Adolescents and Adults With Type 1 Diabetes
This trial is conducted in Europe. The aim of the trial is to investigate the pharmacokinetic (the exposure of the trial drug in the body) properties of FIAsp (faster-acting insulin aspart) in children, adolescents and adults…
- Trial name
- NCT02035371
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Non-REm Sleep inTervention to improvE Diabetes RESTED
Diabetes is a known risk factor for cardiovascular disease. This research aims to improve glucose metabolism in patients with T2DM thereby reducing the impact of diabetes and the subsequent risk of future cardiovascular events.
- Trial name
- RESTED (NCT04120571)
- Testing
- Sleep Audiological Intervention Device (SleepAID)
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Lincoln
High Cholesterol
Technology-Assisted Cholesterol Trial in Consumers (TACTiC)
The purpose of this AUS is to evaluate the extent to which participants can safely and effectively self-select, purchase, and use Crestor OTC 5 mg for a 6-month period according to the label.
- Trial name
- TACTiC (NCT04964544)
- Testing
- 5 mg rosuvastatin calcium with a Web App (combination product)
- Where
- United States
- Volunteers
- 1,196 people
- Sponsor
- AstraZeneca
Hypertension, Type 2 Diabetes Mellitus
Antiproteinuric Effect of Imidapril Versus Ramipril in Type 2 Diabetic and Hypertensive Patients With Microalbuminuria
Numerous clinical and experimental data show that the elective treatment of diabetic nephropathy should be based on drugs that inhibit the renin-angiotensin system (RAS).
- Conditions
- Hypertension, Type 2 Diabetes Mellitus, Microalbuminuria
- Trial name
- NCT01230034
- Testing
- Ramipril, Imidapril
- Where
- Italy
- Volunteers
- 206 people
- Sponsor
- University of Pavia
Type 1 Diabetes, Diabetes in Children
The T1D Parent Check-In: A Preventative Intervention
The goal of this clinical trial is to learn how to best support families during the first year of a child or teen's Type 1 diabetes (T1D) diagnosis.
- Trial name
- NCT06160934
- Testing
- T1D Parent Check-in
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Diabetes, Implant Site Reaction
Laser Biostimulation on Implant Covered With PRF in Controlled Diabetics
the goal of this clinical trial is to evaluate laser biostimulation effect on osseointegration of implant covered by PRF(platelet rich fibrin) in controlled diabetic patients with compromised healing potential.
- Conditions
- Diabetes, Implant Site Reaction, Platelet Rich Fibrin
- Trial name
- PRF (NCT06444334)
- Testing
- low level Diode Laser, PRF platelet rich fibrin
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- National Research Centre, Egypt
Diabetes Mellitus, Type 1, Type 1 Diabetes
"FEXIS": (Feasibility of an Extended Wear CSII Set in Participants With T1DM)
Over 1 million patients globally currently manage their Type 1 Diabetes mellitus using continuous subcutaneous insulin infusion with an infusion set that needs to be changed every 3 days.
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Type 1 Diabetes Mellitus, Diabetes Mellitus, Insulin-Dependent, 1
- Trial name
- FEXIS (NCT04503564)
- Testing
- coil-reinforced soft polymer indwelling cannula
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Capillary Biomedical, Inc.
Type 2 Diabetes
A Study of ZT002 Injection in Adult Chinese Subjects With Type 2 Diabetes Mellitus (T2DM)
This study will comprise a randomized, double blind, placebo controlled, multiple ascending dose, safety, tolerability and pharmacokinetic study of ZT002 in subjects with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT07065032
- Testing
- ZT002 Injection
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
HIV (Human Immunodeficiency Virus), Metabolic Syndrome
Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome
Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced weight loss.
- Conditions
- HIV (Human Immunodeficiency Virus), Metabolic Syndrome, HIV Infections
- Trial name
- NCT00857298
- Testing
- Dietary Intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Non-Insulin-Dependent, Hypertriglyceridemia
PK Study Comparing Metformin Eicosapentaenoate to a Combined Dose of Metformin Hydrochloride and Ethyl Ester EPA
The primary objective of the study is to contrast the pharmacokinetic profiles of metformin and EPA delivered separately as co-administered products (metformin hydrochloride or Glucophage and icosapent ethyl or Vascepa) and…
- Trial name
- NCT02113163
- Testing
- Metformin Eicosapentaenoate, Metformin HCl and Vascepa
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Thetis Pharmaceuticals LLC
Diabetes Mellitus, Type 1
A Multiple Dose Study Investigating Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0363-0845 in Participants With Type 1 Diabetes Pharmacokinetics and Pharmacodynamics: How Insulin NNC0363-0845 is Transported Throughout the Body and How It Works
This study is designed to investigate the movement of insulin NNC0363-0845 throughout the body and how it works for the treatment of type 1 diabetes mellitus.
- Trial name
- NCT05134987
- Testing
- NNC0363-0845, Insulin detemir
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Novo Nordisk A/S
Pancreatic Cancer, Adult, Cephalic Duodenopancreatectomy
Effects of Peptamen 1.6 in Malnourished Patients (or at Risk) With Pancreatic Neoplasia Undergoing Cephalic Pancreaticoduodenectomy (CPD): A Mechanistic Study
Malnutrition is a common challenge in patients with pancreatic cancer undergoing cephalic pancreaticoduodenectomy (CPD), impacting postoperative recovery and overall prognosis.
- Trial name
- NCT06852014
- Testing
- Dietary Supplement: Experimental Treatment with nutritional suplement A + nutritional suplement B, Dietary Supplement: Dietary Supplement: Experimental Treatment with nutritional suplement B + nutritional suplement A
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Obesity
Randomized Controlled Clinical Trial of Weight Loss Programs in Obese Persons
The purpose of this study is to compare two approaches to a diet and exercise-based weight loss program.
- Trial name
- SHINE (NCT00960414)
- Testing
- SHINE
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Glycogen Storage Disease VI, GLYCOGEN STORAGE DISEASE IXa1
GSD VI and GSD IX Natural History
Collection and review of clinical information related to Glycogen Storage Disease Type VI (GSD VI) OR Glycogen Storage Disease Type IX (GSD IX) generated during clinic visits.
- Conditions
- Glycogen Storage Disease VI, GLYCOGEN STORAGE DISEASE IXa1, GLYCOGEN STORAGE DISEASE IXa2, Glycogen Storage Disease IXB
- Trial name
- NCT04454216
- Testing
- No intervention
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Diabetes Mellitus, Renal Impairment
Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
Patients living with diabetes mellitus have double the risk of kidney failure compared to patients without diabetes following use of dye in many x-rays and procedures to diagnose and treat narrowing of the arteries (blood…
- Trial name
- BIOMARKERS (NCT00948116)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Barts & The London NHS Trust
Metabolic Syndrome, Overweight or Obesity
Impact of Time-Restricted Eating on Metabolic Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome
The main purpose of the clinical trial is to determine the health impact of a dietary intervention known as time-restricted eating (TRE) in patients with metabolic syndrome (defined as the presence of elevated fasting plasma…
- Conditions
- Metabolic Syndrome, Overweight or Obesity, PreDiabetes, Weight Loss
- Trial name
- TREMNIOS (NCT04328233)
- Testing
- Time-Restricted Eating
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- Nicolaus Copernicus University
Amyotrophic Lateral Sclerosis
Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis
The purpose of this study will be to demonstrate the safety, tolerability, and efficacy of arimoclomol in subjects with SOD1 positive familial Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT00706147
- Testing
- Arimoclomol
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- University of Miami
Cardiovascular Diseases, Coronary Disease
Framingham Cycle V Offspring-Spouse Nutrition Studies
To examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over seven years using the Cycle V Framingham Offspring/Spouse examination ; to examine the cross-sectional associations between…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005347
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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