Clinical trials: Metabolic and Nutritional Disorders
Obstructive Sleep Apnea, Heart Rhythm Disorder
Obstructive Sleep Apnea Destabilizes Myocardial Repolarization Homogeneity
Literature shows that patients with obesity and Obstructive Sleep Apnea (OSA), both occurring independently, are more likely to develop cardiovascular diseases and sudden cardiac death (SCD).
- Conditions
- Obstructive Sleep Apnea, Heart Rhythm Disorder, Obesity, Abdominal
- Trial name
- NCT04621032
- Testing
- Polygraphy monitoring, laboratory tests
- Volunteers
- 187 people
- Sponsor
- Nowodworskie Centrum Medyczne
Obesity
Intervention Study on Weight Loss in Patients With Obesity
The goal of this clinical trial is to evaluate the feasibility of using Socratic questioning as an alternative method for weight loss in adult patients with obesity (aged 18 to 65) in a primary care setting.
- Trial name
- NCT07124832
- Testing
- Socratic Questioning Method
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Sıdıka Ece Yokuş
Type 1 Diabetes, Type 2 Diabetes
Nurse Telephone Management of Cholesterol in Diabetes
The current project is evaluating the effect of a nurse-administered phone care in diabetes to improve access to care and healthcare delivery.
- Trial name
- NATCHOS (NCT00950963)
- Testing
- Phone Counseling, Standard Clinical Care
- Where
- United States
- Volunteers
- 762 people
- Sponsor
- Denver Health and Hospital Authority
Diabetes Mellitus, Periodontal Disease
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with…
- Trial name
- NCT03444363
- Testing
- Laser group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
GM1 Gangliosidosis
Interviews and Video Capture in Patients With GM1 Gangliosidosis
GM1 gangliosidosis is a rare disease for which there is a limited understanding of disease progression and meaningful outcome measures.
- Trial name
- NCT04310163
- Testing
- Natural history
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- LYSOGENE
Metabolism and Nutrition Disorder, Obesity
Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity
This study will look at the change in participant's body weight from the start to the end of the study. This is to compare the effect on body weight in people taking semaglutide (a new medicine) and people taking "dummy"…
- Trial name
- STEP 4 (NCT03548987)
- Testing
- Semaglutide
- Where
- 72 sites in United States, Denmark and 8 more
- Volunteers
- 902 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2, NAFLD
Screening of Liver Fibrosis Using Blood Tests in Patients With Type 2 Diabetes Mellitus
Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic SteatoHepatitis (NASH), are a frequent complication of type 2 diabetes and obesity.
- Conditions
- Diabetes Mellitus, Type 2, NAFLD, NASH
- Trial name
- L-FibroT2DM (NCT04232293)
- Testing
- Blood tests
- Where
- 2 sites in France
- Volunteers
- 722 people
- Sponsor
- Nantes University Hospital
Obesity, Physical Activity
Incentivizing Physical Activity Using Gamification, A Pilot Study
Juniors and seniors will be recruited to participate in the study, which will begin in the fall 2016 and run through May. The intervention will be a randomized-controlled trial, where students are randomized to either a control…
- Trial name
- NCT02850614
- Testing
- gaming application to encourage physical activity, FitBit
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Lynch Syndrome
NBI Versus Indigo Carmine During Colonoscopy in Lynch Syndrome
This study compares two colonoscopy techniques (with Narrow Band Imaging versus with indigo carmine chromoendoscopy) in patients having Lynch Syndrome
- Trial name
- LYNCH-CHROMO (NCT02570516)
- Testing
- Colonoscopy
- Where
- 7 sites in France
- Volunteers
- 141 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
Shockwave IVL + DES
The objective of this clinical investigation is to evaluate, in a controlled setting, the 12 months safety and efficacy of the combination of Shockwave Intravascular Lithotripsy and a polymer coated Drug Eluting Stent device, for…
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Calcifications Vascular
- Trial name
- Shockwave DES (NCT05291247)
- Testing
- Peripheral lithotripsy system (Shockwave Medical)
- Where
- 6 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Marc Bosiers, MD
Diabetes Complications, Diabetic Neuropathies
Enhance Balance and Mobility in People With Type 2 Diabetic Peripheral Neuropathy
Type 2 diabetes results in a host of neuromuscular, muscular, and autonomic system impairments that accelerate age-associated limitations in functional independence and the risk of falls.
- Trial name
- DPN (NCT02541838)
- Testing
- Muscle power, balance perturbation, aerobic exercise
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Obesity, Overweight
The Effect of Eating Pulses for 8 Weeks on Satiety and Metabolic Syndrome Risk Factors in Overweight Individuals
In 2004, almost 60% of adult Canadians were overweight or obese. This is a serious health concern due to the burden of common health risks associated with being overweight and obese, including increased blood sugar, blood lipids…
- Trial name
- NCT00604448
- Testing
- Dietary advise, Diet enriched with a meal containing pulses
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hyperlipidemias
Effect of ANKASCIN 568-P Products Regulating Blood Lipid
This study is a randomized, double-blind, placebo-controlled, parallel-controlled trial (24 weeks in total), divided into three periods (screening, treatment, and discontinuation follow-up)
- Trial name
- NCT05737355
- Testing
- ANKASCIN 568-P Red yeast rice capsules
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- SunWay Biotech Co., LTD.
Obesity
Tolerance and Pharmacokinetic/Pharmacokinetic Study of IBI362 15mg in Patients With Moderate to Severe Obesity
This study is a multicenter, randomized, partially double-blind (double-blind in both the IBI362 group and the placebo group, with the tirbopeptide group open), placebo and active drug controlled design study
- Trial name
- NCT07000955
- Testing
- Tirzepatide, IBI362
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Hyperlipidemias, Xerosis
Combined Effect of Acitretin and Narrow Band Ultraviolet B on Vitiligo Repigmentation
Since abnormal keratinocyte (KC) proliferation and differentiation as well as defective E cadherin expression were reported in vitiligo lesions, the investigators set to study the potential efficacy of combining Retinoids, which…
- Conditions
- Hyperlipidemias, Xerosis, Depression, Liver Diseases
- Trial name
- NCT04245319
- Testing
- Acitretin, Narrow band ultraviolet B
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Diabetes Mellitus, Type 2
A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight
This study is open to adults who are at least 18 years old and have a body mass index of 27 kg/m² or more. People can take part if they have type 2 diabetes and if they are currently being treated only with diet and exercise or…
- Trial name
- SYNCHRONIZE™-2 (NCT06066528)
- Testing
- Survodutide
- Where
- 143 sites in United States, Australia and 17 more
- Volunteers
- 755 people
- Sponsor
- Boehringer Ingelheim
SIAD - Syndrome of Inappropriate Antidiuresis
Urea for Treatment of Hyponatremia in Patients With SIAD Unresponsive to Fluid Restriction
Hyponatremia due to SIAD is frequently insufficiently corrected by fluid restriction alone, which remains the first-line therapy but is often poorly tolerated. Urea supplementation is recommended as second-line therapy.
- Trial name
- UREA-BIVA (NCT07528365)
- Testing
- urea
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Turin, Italy
Overweight and Obesity
Evaluation of the Effect of Epitomee Device on Gastric Emptying Rate in Healthy Subjects
Evaluation of the effect of Epitomee Device on Gastric Emptying Rate in healthy subjects
- Trial name
- NCT04485936
- Testing
- Epitomee Device
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Epitomee medical
Neonatal Hypoglycemia, Neonatal Hyperglycaemia
Glucose Disturbances in Premature Infants and Quality of Life
The aim of this study is to investigate the correlation between preterm birth, glucose level in the first two hours of life and health related quality of life in the age of 8 months and 7 years
- Trial name
- NCT04770636
- Where
- Croatia
- Volunteers
- 150 people
- Sponsor
- Clinical Hospital Center Rijeka
Obesity
Efficacy and Safety Study of Combination Therapy to Treat Uncomplicated Obesity
The purpose of this study is to determine the efficacy and safety of 3 combinations of naltrexone and bupropion SR compared to naltrexone alone, bupropion SR alone or placebo.
- Trial name
- NCT00364871
- Testing
- naltrexone and bupropion SR
- Where
- 7 sites in United States
- Volunteers
- 410 people
- Sponsor
- Orexigen Therapeutics, Inc
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