Clinical trials: Metabolic and Nutritional Disorders
End-Stage Renal Disease, Type 2 Diabetes Mellitus
A Double-Blind, Randomized, Placebo-Controlled Safety Study Evaluating the Effects of Residual Renal Function (RFF) in Patients With End-Stage Renal Disease and Type 2 Diabetes Mellitus on Peritoneal Dialysis
This study is a multi-center, double-blinded, randomized, study of bardoxolone methyl treatment in patients with End-Stage Renal Disease (ERSD) and Type 2 Diabetes Mellitus (T2DM) on peritoneal dialysis.
- Trial name
- NCT01576887
- Testing
- Bardoxolone Methyl 20 mg
- Sponsor
- Biogen
Glucose Metabolism Disorders, Perioperative Care
Accuracy and Safety of Real Time Continuous Glucose Monitoring Before, During and After Surgery
The purpose of this study is to determine the safety and accuracy of the Real-Time Continuous Glucose monitoring System (RT-CGMS)in measuring glucose in patients scheduled for surgery; before, during and after surgery.
- Trial name
- GluContinu (NCT00464529)
- Testing
- Real-Time Continuous Glucose monitoring System (RT-CGMS)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Research Foundation, The Netherlands
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Insulin Resistance and Coronary Microvascular Dysfunction in Patients With Myocardial Ischemia and Non-obstructive Coronary Artery Disease
The goal of this prospective study is to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA.
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Insulin Resistance
- Trial name
- IRIN (NCT06597851)
- Testing
- Thermodilution based assessment of coronary microcirculation, Hyperinsulinemic-euglycemic Clamp test
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Genetic Predisposition, Metabolic Diseases
GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH
The goal of this research study is to evaluate the pathophysiologic mechanisms by which genetic variation impacts response to an FDA-approved medication commonly used to treat type 2 diabetes called oral semaglutide (Rybelsus)…
- Conditions
- Genetic Predisposition, Metabolic Diseases, Type 2 Diabetes
- Trial name
- GLUCOSE-MGH (NCT06003153)
- Testing
- oral semaglutide, Mixed Meal Tolerance Test (MMTT)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypercholesterolemia
A Multicenter, Active and Placebo-controlled Study of Enteric Coated Sevelamer in Patients With Mild to Moderate Hypercholesteremia
A total of 120 patients will be entered in this study to assess the safety and efficacy of enteric coated sevelamer (ECS) to lower LDL cholesterol.
- Trial name
- Sevelamer ECS (NCT00690937)
- Testing
- Enteric coated sevelamer, Colesevelam Cholestagel
- Where
- 8 sites in India
- Volunteers
- 120 people
- Sponsor
- Genzyme, a Sanofi Company
Diabetes Mellitus, Type 2
Reaching Better Health Study: A Website to Improve Type 2 Diabetes Self-Management
Diabetes is one of the most common chronic illnesses among adults in the United States. Internet-based interventions and health promotion websites for patients with Type 2 Diabetes are typically low-cost, easily accessible, and…
- Trial name
- REACH (NCT02757937)
- Testing
- Health & Wellness Website, Control Arm
- Volunteers
- 513 people
- Sponsor
- Children's Hospital of Philadelphia
Morbid Obesity, Surgery
Ketamine Infusion vs Dexmedetomidine Infusion in Obese Patients Undergoing Bariatric Surgery
The surgeries that involve treatment of morbid obesity, i.e. bypass procedure and sleeve gastrectomy, are collectively covered under the term 'bariatric surgery'.
- Trial name
- NCT04576975
- Testing
- Ketamine, Dexmedetomidine, Normal Saline 0.9%
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Diabetes
Northern Manhattan Diabetes Community Outreach Project
The objective of this study is to examine the effectiveness of a community health worker intervention at helping to control diabetes among Latinos with poorly controlled Type 2 diabetes.
- Trial name
- NOCHOP (NCT00787475)
- Testing
- Community Health worker
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Columbia University
Type 2 Diabetes
Vildagliptin Versus Liraglutide - Patient Preference After Receiving Both Medications
Dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagonlike peptide-1 (GLP-1) mimetics or analogs, which rely on the gastrointestinal hormones that are part of the incretin system for the treatment of T2DM, provide a therapeutic…
- Trial name
- PREFER (NCT01518101)
- Testing
- Vildagliptin/ Metformin, Liraglutide, Metformin
- Where
- 8 sites in Germany
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
Weight Management Skills in African American Outpatients
Our long-term goal is to identify new insights about effective approaches to obesity management and related lifestyle changes in African Americans and about factors that enhance or limit the response to specific treatment…
- Trial name
- SHARE (NCT00146081)
- Testing
- Weight Management
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- University of Pennsylvania
Vitamin D Deficiency
Physical Exercise and Diet Management in Vitamin D Deficient Females
The purpose of this study was to determine if home based physical exercises protocol and Diet management has an effect on functional performance and depression level related to vitamin D deficiency in females.
- Trial name
- NCT06114381
- Testing
- Home Based Physical Exercise, Vitamin D3 Supplements, Diet Management
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Badr University
Osteoporosis, Obesity
Breastfeeding and Exercise for Healthy Infants and Postpartum Moms Too!
Approximately 8 million American women suffer from osteoporosis, and one out of every two women over the age of 50 will have an osteoporotic-related fracture in their lifetime (42).
- Conditions
- Osteoporosis, Obesity, Weight Loss
- Trial name
- BEHIP (NCT00966381)
- Testing
- Exercise and weight loss intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Malaria, Diabetes Mellitus
Diabetes, Metabolic Syndrome and Risk of Malaria in Cameroon
Non-communicable diseases (NCDs) such as diabetes are increasing in countries where malaria transmission is common. This study aims to investigate the relationship between NCDs and parasitic infections in Cameroon.
- Conditions
- Malaria, Diabetes Mellitus, Metabolic Syndrome, Endemic
- Trial name
- NCT06278181
- Where
- Cameroon
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Prader-Willi Syndrome, Resistance Training
Effects of Progressive Elastic Band Resistance Training
Abnormal body composition with increased body fat mass and decreased lean body mass has been found in adults with Prader-Willi syndrome (PWS), contributing to reduced physical capacity and impairment.
- Trial name
- NCT03565081
- Testing
- PWS elastic band training group
- Volunteers
- 6 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Diabetes Mellitus, Type 2, Myocardial Infarction
Effect of Patient Education on Healthy Lifestyle Behaviors and Diabetes Self-management in Diabetics
The purpose of this study is to determine the effect of planned education given to individuals with diabetes mellitus who had myocardial infarction on healthy lifestyle behaviors and diabetes self-management.
- Trial name
- NCT05954819
- Testing
- Planned patient education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Istanbul University - Cerrahpasa
Diabetes Mellitus, Type 2
Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes
The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
- Trial name
- NCT00168519
- Testing
- nitroprusside, pentalong, imdur, AICAR, isoptin
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baker Heart Research Institute
Type 2 Diabetes, Hypertension
Individually Tailored Treatment of Type 2 Diabetes
The prevalence of Type 2 diabetes (T2D) is rising rapidly worldwide. In Denmark approximately 8% of adults have T2D and more than 25.000 are diagnosed each year. This has vast consequences for society and the patient.
- Trial name
- ITT (NCT02015130)
- Testing
- Individual treatment
- Where
- 4 sites in Denmark
- Volunteers
- 2,246 people
- Sponsor
- Odense University Hospital
Hypercapnic Respiratory Failure, Sleep Disordered Breathing
Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation
Patients are invited to participate in a trial to test a new way to optimise long-term use of non-invasive ventilation using remote monitoring.
- Conditions
- Hypercapnic Respiratory Failure, Sleep Disordered Breathing, COPD, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- READ-NIV (NCT04884165)
- Testing
- Remote monitoring of home mechanical ventilation (NIV) using SRETT, Home mechanical ventilation (NIV) without remote monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Inflammation, Insulin Resistance
Mechanisms of Insulin Resistance in Humans
The Objectives of the study are to: (1)compare the inflammatory response and insulin resistance in skeletal muscles during a systemic infusion of lipid with that during a local infusion of lipid into the femoral artery.
- Trial name
- NCT00330967
- Testing
- 20% Intralipid
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Obese
Home-Based HIT in Obese Individuals
This study aims to investigate the efficacy of a novel home-based high-intensity interval training (Home-HIT) intervention in obese individuals, with elevated cardiovascular disease (CVD) risk.
- Trial name
- NCT03557736
- Testing
- Training mode
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Liverpool John Moores University
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