Clinical trials: Metabolically Healthy Obesity
Obesity
Follistatin Levels in Metabolically Healthy and Unhealthy Obese Individuals
There is no clear boundary on which obese individuals should be considered metabolically healthy and which should be considered metabolically unhealthy.
- Trial name
- NCT06229899
- Testing
- Serum follistatin levels
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Obesity Adult Onset
Gut Microbiota, Mitochondrial Function and Metabolic Health in Obesity
It has been suggested that individuals with the condition known as metabolically healthy obesity (MHO) may not have the same increased risk of developing metabolic abnormalities as their non-metabolically healthy counterparts.
- Trial name
- NCT06279780
- Testing
- very low-calorie diet
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Celia Bañuls
Healthy Obesity, Metabolically, Obesity
Determining the Physiological Mechanisms Behind the ObeEnd Device on Factors Regulating Appetite
In Canada, over 60% of adults are classified as overweight and obese resulting in a public health crisis including increasing health care costs and negatively impacting the well-being of many Canadians.
- Trial name
- NCT06411483
- Testing
- ObeEnd Band
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Obesity
Metabolically Healthy Obesity: Correlations Between BMI and Metabolic Syndrome Biomarkers
The study team's research fills the gap in the obesity literature where BMI with a cut point of 35 is frequently used to show the association between BMI and metabolic syndrome biomarkers.
- Trial name
- NCT03195712
- Where
- United States
- Volunteers
- 691 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Overweight, Obesity
Individual Factors Related to Chronic Low-grade Inflammation and Cardiometabolic Disease Risk
The goal of this observational study is to learn about low-grade inflammation in healthy individuals and individuals with overweight or obesity.
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Healthy
- Trial name
- PINEAPPL (NCT06355544)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Integrative Phenomics
Healthy, Obesity, Metabolically
A First in Human (FIH) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DR10624
DR10624 is an Fc fusion protein tri-agonist with balanced glucagon-like peptide-1 receptor (GLP-1R)/glucagon receptor (GCGR)/ fibroblast growth factor 21 receptor (FGF21R) agonizing activities.
- Trial name
- NCT05378893
- Testing
- DR10624 for injection
- Where
- New Zealand
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Zhejiang Doer Biologics Co., Ltd.
Metabolic Syndrome, Obesity
Mobile Health (M-health) Intervention to Reduce the Epigenetic Signature in Metabolic Syndrome (MetS)
The goal of this interventional study is to learn about the improvement in body composition effects of lifestyle intervention in subjects with metabolic syndrome.
- Trial name
- NCT06448806
- Testing
- mobile health lifestyle intervention
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Healthy Obesity, Metabolically, Appetite Regulation
Colonic Propionate, Appetite, and Weight Loss
The current protocol aims to investigate the impact of the propionate ester in conjugation with restricted diet on appetite and weight loss.
- Trial name
- ProAp (NCT03322514)
- Testing
- Inulin-Propionate Esters, Inulin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Metabolic Syndrome
Cognitive Dysfunction in People Who Are Obese But Metabolically Healthy
There is some evidence to suggest that obesity is a risk factor for the development of cognitive dysfunction, although this is not a universal finding.
- Trial name
- NCT01928355
- Volunteers
- 60 people
- Sponsor
- Ziv Hospital
Obesity, Weight Loss
Effects of Physical Activity on Weight Loss and Weight Maintenance in Obese Adults - Three Year Follow-up Study
Objective To study if exercise added to weight loss treatment at the beginning of the weight loss intervention or at 6 months could sustain the weight loss achieved or give extra boost for weight reduction.
- Conditions
- Obesity, Weight Loss, Physical Activity, Healthy Obesity, Metabolically
- Trial name
- LILA (NCT03861754)
- Testing
- Lifestyle modification
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Oulu
Metabolic Syndrome, Obesity & Overweight
Breath Mass Spectrometry in Metabolic Syndrome and Metabolically Healthy Obesity
This study aims to develop a non-invasive diagnostic method for metabolic syndrome (MetS) and metabolically healthy obesity (MHO) through analysis of exhaled air.
- Conditions
- Metabolic Syndrome, Obesity & Overweight, Metabolically Healthy Obesity
- Trial name
- NCT07330297
- Testing
- Breath Sampling and Analysis by PTR-MS
- Where
- Russia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Metabolic Syndrome, Healthy Participants
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity.
- Conditions
- Metabolic Syndrome, Healthy Participants, Metabolically Healthy Obesity, Metabolically Abnormal Obesity
- Trial name
- NCT07095426
- Testing
- inulin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ball State University
Metabolically Healthy Obesity
Brown Fat Tissue Related Hormone Levels in Metabolically Healthy and Unhealthy Obese Individuals
There are two types of adipose tissue in humans, white and brown adipose tissue. While the main task of white adipose tissue is energy storage, the main task of brown adipose tissue is energy expenditure.
- Trial name
- NCT05232695
- Testing
- metabolically healthy obese
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Obesity, Metabolic Syndrome
Metabolically Healthy Obese
Little is known about the associated factors and mechanisms involved in the development of metabolic disturbance in pediatric obesity.
- Trial name
- MHO (NCT06032312)
- Testing
- description
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obesity
Early Detection of Renal Abnormalities in Metabolically Healthy and Unhealthy Weight Excess"
Overweight and obesity are increasingly prevalent worldwide. Weight excess increases the risk of in developing the metabolic syndrome, which is composed by a set of cardiometabolic risk factors such as abdominal adiposity…
- Trial name
- OB-KID (NCT06338631)
- Testing
- Diet
- Where
- 2 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Istituto Auxologico Italiano
Metabolically Healthy Obesity
Gut, Immune, and Vascular Health in Metabolically Healthy Obesity
The investigators seek to better understand how a single high-fat meal impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity" (obesity and largely normal cardiometabolic profile) and…
- Trial name
- NCT07559227
- Testing
- Inulin Supplementation, High-fat meal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ball State University