Clinical trials: Metabolism Changes
Diabetes Mellitus Type 2
Effects of Empagliflozin + Linagliptin vs Metformin + Insulin Glargine on Renal and Vascular Changes in Type 2 Diabetes
Diabetes mellitus is a wide-spread disease accompanied by strongly increased morbidity and mortality due to micro- and macrovascular complications.
- Trial name
- ELMI (NCT02752113)
- Testing
- Empagliflozin and Linagliptin, Metformin and Insulin sc
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Type 2 Diabetes Mellitus, Fear of Hypoglycemia
Effects of a Health Intervention on Fear of Hypoglycemia : a Pilot Study
The purpose of this study was to construct a Fear of Hypoglycemia(FoH) intervention program for type 2 diabetic patients based on the Behaviour Change Wheel (BCW) theory and to investigate the feasibility, acceptability, and…
- Conditions
- Type 2 Diabetes Mellitus, Fear of Hypoglycemia, Health Education, Impaired Awareness of Hypoglycemia
- Trial name
- NCT06197360
- Testing
- Based on BCW Theory of Health Education, General diabetes health education
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yangzhou University
Diabetes
Life Style Modifications Prevents Type 2 Diabetes in Asian Indians
Three year prospective randomised controlled trial in IGT subjects to study the effect of metformin and lifestyle modification in preventing the conversion to diabetes
- Trial name
- NCT00279240
- Testing
- Metformin
- Where
- India
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.V. Hospital for Diabetes
Pediatric Obesity
Medications After Adolescent Bariatric Surgery
This study will assess the feasibility to assess practicality of early weight loss medication usage in adolescent patients post-VSG with inadequate weight loss.
- Trial name
- MAABS Protocol (NCT04572217)
- Testing
- Topiramate, Phentermine
- Where
- United States
- Sponsor
- Janey Pratt
Prediabetes, Vitamin D Deficiency
Effect of Vitamin D Deficiency and Vitamin D Supplementation on Glucose Metabolism
This study was intended to evaluate the effect of vitamin D supplementation on insulin sensitivity and pancreatic islet beta-cell function.
- Trial name
- NCT00749918
- Testing
- Cholecalciferol (vitamin D3)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Chronic Hepatitis B, Hepatic Steatosis
Liver Status and Presence of MASLD/MASH in Patients With Chronic Hepatitis B
The aim of the study was to evaluate the consistency between liver biopsy and Liver Stiffness Measurement (LSM) for fibrosis and controlled attenuation parameter (CAP) for steatosis in FibroScan® in patients with chronic…
- Trial name
- Faraday (NCT06573190)
- Testing
- Transient elastography, Tenofovir Disoproxil Fumarate
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Yaşar Bayındır, MD
Nutrition Status
Malnutrition Prevalence and Nutritional Change After Preoperative Nutrition Counseling
Preoperative nutrition risk or Malnutrition is a prevalent up to 65% of surgical patients, leading to significant negative outcomes such as increased complications, poor wound healing, and higher healthcare costs.
- Trial name
- NCT07125859
- Where
- Thailand
- Volunteers
- 600 people
- Sponsor
- Siriraj Hospital
Gestational Weight Gain
Metabolic Tracking and Weight Gain During Pregnancy
In this study, the investigators aimed to have pregnant women use a hand-held device to track increases in daily caloric needs during pregnancy.
- Trial name
- NCT04131023
- Testing
- Breezing Metabolic Rate Tracking
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Obesity
Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese
The purpose of this study is to determine what changes occur in body- and liver-composition during four weeks of low calorie diet in morbidly obese females
- Trial name
- NCT01842425
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
GLP-1, Nutrition
The Effect of Pharmacotherapy With GLP-1 and GIP/GLP-1 Analogs on Changes in Qualitative and Quantitative Parameters of the Diet as Well as Metabolic and Behavioral Parameters in Patients With Excess Body Weight
The aim of this study is to comprehensively assess the early and long-term effects of GLP-1 and GIP/GLP-1 analogue medications on metabolic and behavioral parameters, with particular emphasis on qualitative and quantitative…
- Trial name
- NCT07270497
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Obesity, Weight Loss
Healthy Eating Patterns During a Lifestyle Intervention
The purpose of this study is to address the gap in knowledge regarding the relationship between eating frequency and weight loss.
- Trial name
- HEP (NCT01682317)
- Testing
- Eating Frequency
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Overweight, Obesity
Pedometer Use to Prevent Excessive Pregnancy Weight Gain in Overweight Women
The purpose of this study is to evaluate pedometer use by overweight women during pregnancy. The study will show if a pedometer will help women to limit weight gain during pregnancy.
- Conditions
- Overweight, Obesity, Pregnancy
- Trial name
- NCT01469260
- Testing
- Pedometer
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Autism Spectrum Disorder, Obesity
Open Trial Obesity CHANGE Program ASD
The purpose of this study is to determine if a program can help children with autism who are overweight. Specifically, this study will look to see if changes in a child's eating habits and exercise can help with weight loss.
- Trial name
- NCT03047018
- Testing
- The Changing Health in Autism through Nutrition, Getting fit and Expanding variety (CHANGE) Program
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Emory University
Body Weight Changes, Overweight
Lifestyle Education for Activity and Nutrition for a Leaner You
Although weight loss programs are effective in the short-term, maintaining weight loss is more challenging. Regularly tracking and logging physical activity (PA) and diet is related to greater improvements in PA and diet and to…
- Trial name
- LEAN (NCT00957008)
- Testing
- Group weight loss program, Group weight loss program plus use of the Senseware Armband, Use of the senseware armband alone program
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Platelet-rich Fibrin, Simvastatin
Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
ACKGROUND: Simvastatin (SIM), a pharmacological drug used for hypercholesterolemia, has been found to have pleotropic effects on bones. Simvastatin together with the appropriate carrier may decrease bone loss around implants.
- Trial name
- NCT05008068
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Metabolic Response to Dietary Modification
The CLOCK Study - A Human Dietary Intervention Study on Peripheral Circadian Clocks and Energy Metabolism
This human dietary intervention study with a cross-over design aims to investigate the effect of two different diurnal patterns of meal composition on peripheral circadian clocks and energy metabolism in healthy men.
- Trial name
- CLOCK (NCT02487576)
- Testing
- Carbohydrate-rich (HC), Fat-rich (HF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Type 2 Diabetes, Overweight
Mechanisms of Weight Loss With SGLT2 Inhibition
The purpose of this study is to investigate the effect of canagliflozin, a medication approved by the FDA for the treatment of type 2 diabetes, on body weight and metabolism in people with type 2 diabetes who are overweight or…
- Conditions
- Type 2 Diabetes, Overweight, Obesity
- Trial name
- NCT02360774
- Testing
- Canagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Beth Israel Deaconess Medical Center
Gestational Weight Gain, Physical Activity
Construct and Evaluate the Effectiveness of a Theory-based mHealth for Overweight and Obese Women During Pregnancy
This study was to construct and develop an application (APP) based on social-cognitive theory for overweight and obese women during pregnancy.
- Trial name
- NCT04553718
- Testing
- experimental group
- Where
- Taiwan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Mackay Medical College
Overweight and Obesity
Lifestyle Intervention for Healthy Change
The purpose of this study is to determine the effectiveness of a physician led, multi-disciplinary approach to treating obesity that incorporates nutrition (mainly, using genetics to identify appropriate food intake), exercise…
- Trial name
- LIVE WELL (NCT05956574)
- Testing
- Nutrigenomix, personalized dietary plan, Physical Activity, Behavioral counseling
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Augusta University
Overweight and Obesity
Evaluation of the Plant-based Approaches to Stop Obesity Diet for the Treatment of Overweight and Obesity
The accumulation of excess of body weight is one of the most important problems worldwide, thus effective and accessible treatments are required.
- Trial name
- PASO diet (NCT03608176)
- Testing
- PASO diet group, Low-fat diet group, Waiting list group
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Universidad de Sonora