Clinical trials: Metabolism Disorder, Glucose
Type 2 Diabetes
Comparing Self Monitored Blood Glucose (SMBG) to Continuous Glucose Monitoring (CGM) in Type 2 Diabetes
The purpose of this study is to evaluate the use of SMBG and CGM for clinical decisions related to the management of type 2 diabetes.
- Trial name
- REACT3 (NCT01237301)
- Testing
- CGM Group, SMBG Group
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- HealthPartners Institute
Diabetes Mellitus, Non-Insulin-Dependent
An Evaluation of an Oral Antidiabetic Agent for the Treatment of Type 2 Diabetes
The purpose of this study is to determine if an investigational drug is safe and efficacious for poorly controlled type 2 diabetes mellitus.
- Trial name
- NCT00065312
- Testing
- naveglitazar
- Where
- 42 sites in United States
- Sponsor
- Eli Lilly and Company
Cardiovascular Autonomic Neuropathy, Type 2 Diabetes
Finerenone Treatment for Diabetic Cardiovascular Autonomic Neuropathy: the FibroCAN Study
Diabetic neuropathy is a serious and common complication of diabetes that currently has no cure. One form of this condition is cardiovascular autonomic neuropathy (CAN), which affects about 20% of people with diabetes-an…
- Conditions
- Cardiovascular Autonomic Neuropathy, Type 2 Diabetes, Diabetic Neuropathies
- Trial name
- FibroCAN (NCT06906081)
- Testing
- Kerendia (Finerenone, BAY94-8862)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Peter Rossing
Type 2 Diabetes
The Effect of LINAGLIPTIN on Inflammation, Oxidative Stress and Insulin Resistance in Obese Type 2 Diabetes Subjects
This is a single center, prospective randomized double blind, parallel and placebo controlled study to evaluate oxidative stress and inflammation before and after treatment with linagliptin for 12 weeks.
- Trial name
- 1971 (NCT02372630)
- Testing
- Linagliptin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University at Buffalo
Diabetes Mellitus
Feasability of a Care Pathway Integrating Collaborative Tele-expertise to Prevent Recurring Hospitalisations for Diabetic Patients
Telemedicine for diabetic patients is currently based simply on remotely monitoring capillary blood glucose levels. This experimental approach remains limited to insulin-treated diabetic patients with sufficient motivation and…
- Trial name
- TELXCODIA (NCT04769765)
- Testing
- Definition of the Individualized Care Pathway
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Periodontitis, Type 2 Diabetes
Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients
This study investigates the relationship between Type 2 diabetes mellitus (T2DM), glycemic control, and periodontal disease. Researchers analyzed the levels of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines…
- Conditions
- Periodontitis, Type 2 Diabetes, Glycemic Control
- Trial name
- NCT06803836
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Type2 Diabetes, Type1diabetes
Accuracy Characterization Study
To demonstrate point accuracy of the Abbott Sensor Based Glucose Monitoring System (System) interstitial glucose results against venous glucose reference and capillary fingerstick using the Consensus Error Grid over the wear…
- Conditions
- Type2 Diabetes, Type1diabetes, Insulin Dependent Diabetes
- Trial name
- ACS (NCT01932944)
- Testing
- No treatment
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Abbott Diabetes Care
Type 2 Diabetes Mellitus
FTIH of ECC5004 in Healthy and Diabetic Participants
This is a Phase 1, randomized, double-blind, placebo-controlled, single ascending dose and multiple ascending dose study of ECC5004 in healthy participants and in patients with Type 2 Diabetes Mellitus
- Trial name
- NCT05654831
- Testing
- ECC5004
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Eccogene
Diabetes, Type 1 Diabetes
The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes
The purpose of this study is to determine if the drug Alpha-1 Antitrypsin (AAT, Aralast NP) will preserve beta-cell function and help slow the progression of type 1 diabetes.
- Trial name
- NCT01319331
- Testing
- Alpha 1-Antitrypsin (AAT, Aralast NP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Obesity, Overweight
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with overweight and type 2 diabetes.
- Conditions
- Obesity, Overweight, Type 2 Diabetes
- Trial name
- NCT06972472
- Testing
- Orforglipron
- Where
- 80 sites in United States, Argentina and 5 more
- Volunteers
- 600 people
- Sponsor
- Eli Lilly and Company
Obesity, Abdominal, Insulin Resistance
Persea Americana for Total Health (PATH ) Study
The proposed work will investigate the effects of avocados on abdominal obesity and glycemic control among overweight/obese adults.
- Conditions
- Obesity, Abdominal, Insulin Resistance, Insulin Sensitivity
- Trial name
- PATH (NCT02740439)
- Testing
- Avocado, Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Cancer, Injury of Liver
Implementing Online Patient-Provider Communication Into Clinical Practice
This interdisciplinary, international collaboration study, including the the Norwegian Health Economy Administration (HELFO) will evaluate the effectiveness and real-world implementation of an online patient-provider…
- Conditions
- Cancer, Injury of Liver, Diabetes
- Trial name
- OPPC (NCT00971139)
- Testing
- Access to an OPPC service
- Where
- Norway
- Volunteers
- 199 people
- Sponsor
- Oslo University Hospital
Obesity, Inflammation
Combining HIIT and n-3 PUFA to Reduce Inflammation and Improve Metabolic Health
The goal of this project is to understand the combined effects of fish oil and exercise in obesity-associated inflammation. The investigators hypothesize that fish oil will improve gut bacteria profiles, which will in turn…
- Conditions
- Obesity, Inflammation, Human Microbiome, Insulin Resistance
- Trial name
- HIIT&PUFA (NCT05295719)
- Testing
- Omega-3 polyunsaturated fatty acid, High-Intensity Interval Training, Safflower oil
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Texas Tech University
Heart Failure, High Blood Pressure
BVA-200 vs BVA-100 Validation Study
The proposed study is a prospective, observational, investigator and patient blinded study comparing the results of blood volume measurement using the FDA-cleared Daxor BVA-100 device to the Daxor BVA-200 device.
- Conditions
- Heart Failure, High Blood Pressure, High Cholesterol, Anemia
- Trial name
- NCT06227819
- Testing
- BVA-200
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Daxor Corporation
Type 2 Diabetes Mellitus
Simplified Onboarding in Adults With Type 2 Diabetes
This is an outpatient study testing different starting doses of insulin in participants with type 2 diabetes. Participants will manage their diabetes using the Omnipod M System.
- Trial name
- SIMPLEUSE (NCT07070830)
- Testing
- Active Comparator: Omnipod M System with lower starting dose, Active Comparator: Omnipod M System with higher starting dose
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- Insulet Corporation
Diabetes Type II
Novel Biomarker for Development of T2D
The investigators wants to determine if 11β-HSD1 activity will be positively associated, and 5α-reductase activity negatively associated, with (a) degree of insulin resistance defined by the homeostatic model assessment of…
- Trial name
- NCT02326129
- Where
- 3 sites in United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Duke University
Overweight , Obesity, Prediabetes
Smartwatch-based Intervention for Cardiovascular Health (SWITCH)
This study aims to employ a cluster randomized controlled trial to evaluate the effectiveness of an mHealth-Based Multi-faceted Cardiovascular Health Intervention Model among metabolically at-risk people with overweight/obesity…
- Conditions
- Overweight , Obesity, Prediabetes, High-normal Blood Pressure, Borderline Elevated Blood Lipids
- Trial name
- NCT07372729
- Testing
- Smartwatch-Based Multi-Faceted Behavioral Intervention Model Led by Exercise and Dietary Interventions, Supported by Primary Medical Staff, Along with the Distribution of Health Education Manuals, Face-to-face health education sessions
- Where
- 3 sites in China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Diabetes Mellitus, Type 1, Type 1 Diabetes Mellitus
Treatment of Diabetic Neuropathy With Liraglutide
The purpose of this trial is to explore whether liraglutide has a long term effect on clinical symptoms and biomarkers in patients with diabetic neuropathy.
- Trial name
- TODINELI (NCT02138045)
- Testing
- Liraglutide treatment
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Aalborg University Hospital
Type 2 Diabetes, Coronary Heart Disease
Trial on Safety & Performance of TAXUS Element vs. XIENCE Prime Stent in Treatment of Coronary Lesion in Diabetics
The TUXEDO-India is a prospective, single blind, multi-center randomized clinical trial to assess the TAXUS Element™ in a consecutive population of diabetic patients with coronary artery disease undergoing coronary…
- Trial name
- Tuxedo (NCT03125772)
- Testing
- TAXUS Element™ Paclitaxel-Eluting Stent System, Xience PRIME Everolimus-Eluting Stent System
- Where
- India
- Volunteers
- 1,830 people
- Sponsor
- Fortis Escorts Heart Institute
Diabetes
Avoiding Diabetes After Pregnancy Trial in Moms
Mothers with previous gestational diabetes mellitus (GDM) represent a population at higher risk of future Type 2 diabetes mellitus (T2DM), which is preventable through lifestyle modification.
- Trial name
- ADAPT-M (NCT01918345)
- Testing
- Home-based Physical Activity Program with Health Coach, Home-based Low-GI Diet Program with Health Coach
- Where
- 5 sites in Canada
- Volunteers
- 345 people
- Sponsor
- Women's College Hospital
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