Clinical trials: Metabolism Disorder
Gamification, Type 2 Diabetes
The Effect of Gamification on Patients With Type 2 Diabetes
Diabetes is a broad-spectrum metabolic disorder that causes a defect in the organism's carbohydrate, fat, and protein metabolism processes due to insulin deficiency or impaired insulin effect.
- Conditions
- Gamification, Type 2 Diabetes, Self-management, Digital Health
- Trial name
- NCT05725330
- Testing
- Gamification and education with mobile game application
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Sakarya University
Obesity
Identification of Novel Targets for Regulation of Adipose Tissue Mass
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders.
- Trial name
- NCT00773565
- Testing
- Optifast
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Gottfried Rudofsky
T2DM (Type 2 Diabetes Mellitus)
Bioequivalence Study of Chiglitazar/Metformin Extended-Release Tablets
This is a single-center, randomized, open-label, two-period, two-sequence crossover bioequivalence study under fed conditions. The primary objective is to evaluate the bioequivalence of a single oral dose of the test formulation…
- Trial name
- NCT07519265
- Testing
- Chiglitazar/Metformin extended-release fixed-dose combination tablet, dose 1, Chiglitazar tablet, dose 1, Metformin extended-release tablet, dose 1
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Chipscreen Biosciences, Ltd.
Type 2 Diabetes, Dyslipidemia
Fenofibrate and Metformin Insulin Sensitivity in Type 2 Diabetics Study
Double-blind, randomized placebo-controlled study in type 2 diabetes and dyslipidemic patients.Patients will be randomized to one of four treatment arms for 16 weeks: placebo, fenofibrate, metformin, or metformin and fenofibrate…
- Trial name
- NCT00362765
- Testing
- Fenofibrate, Metformin
- Where
- 3 sites in Finland, Ireland and 1 more
- Volunteers
- 8 people
- Sponsor
- Solvay Pharmaceuticals
Neurological Disorder, ALS (Amyotrophic Lateral Sclerosis)
INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study
INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study
- Conditions
- Neurological Disorder, ALS (Amyotrophic Lateral Sclerosis), Motor Neuron Disease, ALS - Amyotrophic Lateral Sclerosis
- Trial name
- NCT07543367
- Testing
- Stentrode
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Synchron, Inc.
Malignant Soft Tissue Sarcoma
Use of Propranolol Hydrochloride in the Treatment of Metastatic STS
Fifty patients with pathological proof of malignant soft tissue sarcoma will receive Anthracyclin based chemotherapy combined with propranolol 40 mg twice daily.
- Trial name
- NCT03108300
- Testing
- Propranolol Hydrochloride, Doxorubicin
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Epilepsy, Epilepsy Intractable
Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet
The purpose of this pilot study is to measure adherence and quality of life in adults with intractable epilepsy following the Modified Atkins Diet (MAD) with Betaquik, a ready-to-use medium chain triglyceride (MCT) emulsion, as…
- Conditions
- Epilepsy, Epilepsy Intractable, Seizures, Seizure Disorder
- Trial name
- NCT03790436
- Testing
- Betaquik
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Dyslipidemia, Atherosclerosis
Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions
Background: The right amount of fats in the blood (cholesterol and triglycerides) are a key part of a healthy organism. Too much or too little of these fats may manifest as diseases (dyslipidemia).
- Trial name
- NCT06676046
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity
Geisinger Education Intervention Study in Obesity Protocol
Overweight and obesity has become an epidemic which warrants more aggressive treatment. However, few primary care physicians (PCPs) address this issue or do not possess adequate education regarding treatment modalities such as…
- Trial name
- GEISO (NCT01160146)
- Where
- United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Hyperlipidaemia, Hyperlipidemia
Nigella Sativa Supplementation in Hyperlipidemia Treatment
Hyperlipidemia is defined as an elevation of plasma cholesterol, lipid, or lipoprotein levels above normal due to abnormal fat metabolism or function, and individuals with hyperlipidemia are approximately twice as likely to…
- Trial name
- NCT06890546
- Testing
- Nigella Sativa Oil capsule, Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul Bilgi University
Obesity
The Effect of Nutrisystem Meal Provision on Weight
The study is to determine the effect of a behavioral weight loss program supplemented with Nutrisystem meal replacements on weight, blood pressure, fasting blood glucose, and blood lipids levels over 12 weeks.
- Trial name
- NCT01252303
- Testing
- Nutrisystem
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Obesity
Bioimpedance Analysis for Follow-up of Dieters
Prospective, single arm, dietary intervention study.
- Trial name
- BIA (NCT02975427)
- Testing
- Diet group
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Celiac Disease
A Low FODMAPs Diet in Celiac Patients With Persistent Gastrointestinal Symptoms
FODMAPS (fructose, oligosaccharides, monosaccharides, disaccharides and polyols) are characterised as fermentable but poorly absorbed carbohydrates which enter the colon and are utilised by colonic bacteria.
- Trial name
- NCT02946827
- Testing
- Balanced low FODMAPs /gluten free diet, Balanced gluten free diet
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Type 2 Diabetes
The Drug-drug Interaction of SHR3824 and Metformin
The purpose of the study is to investigate the potential interaction between multiple oral doses of SHR3824 and a single oral dose of metformin in healthy adult volunteers.
- Trial name
- NCT02354027
- Testing
- SHR3824 metformin
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Type 2 Diabetes Mellitus
Effects of Glimepiride on Recovery From Hypoglycemia in Participants With Type 2 Diabetes Mellitus (MK-0000-253)
This study aims to assess how glimepiride affects the recovery from hypoglycemia in participants with type 2 diabetes mellitus. The primary objective is to estimate the time taken by participants to recover from hypoglycemia to…
- Trial name
- NCT01614769
- Testing
- Glimepiride 2 mg, Glimepiride 4 mg, Hypoglycemic Clamp
- Volunteers
- 10 people
- Sponsor
- Merck Sharp & Dohme LLC
Fabry Disease
Safety and Pharmacokinetics of AT1001 (Migalastat HCl) in Healthy Subjects and Subjects With Impaired Renal Function
This study will assess the safety, tolerability, and pharmacokinetics (PK) study of a single dose of 150 mg AT1001 (migalastat HCl, GR181413A) administered orally to healthy subjects with normal renal function and to subjects…
- Trial name
- NCT01730469
- Testing
- AT1001 150 mg
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amicus Therapeutics
Binge Eating Disorder, Binge Eating
Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents
The main purpose is to investigate the effectiveness of a 10-week multicomponent camp intervention to reduce BE behavior in children and adolescents and explore in a randomized controlled setting if a parent-based…
- Conditions
- Binge Eating Disorder, Binge Eating, Loss of Control Eating, Overweight , Obesity
- Trial name
- STOB (NCT07301541)
- Testing
- A 10-week multicomponent camp intervention for children, A BED intervention for parents
- Where
- 2 sites in Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Congenital Hyperinsulinism (CHI), Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI)
Phase II Safety and Efficacy Study of 18FDOPA PET-CT in Children With Hyperinsulinemic Hypoglycemia
Children with congenital hyperinsulinism (CHI) have low blood sugar, and some of these children may require surgery to remove part or all of their pancreas.
- Trial name
- 18FDOPA (NCT01468454)
- Testing
- 18 F-DOPA
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Children's Hospital of Philadelphia
Malnutrition, Malnutrition, Child
Double Duty Interventions and Its Impact on Double Burden of Malnutrition in Children Under Five Years
Background: Double burden of malnutrition is an emerging public health problem among children under-five years due to the inevitable consequences of nutritional transition.
- Conditions
- Malnutrition, Malnutrition, Child, Obesity, Undernutrition
- Trial name
- DBM (NCT05791305)
- Testing
- double duty intervention packages
- Where
- 2 sites in Ethiopia
- Volunteers
- 456 people
- Sponsor
- Debre Berhan University
Iron Deficiency Anemia
IRON DEFICIENCY ANEMIA IN RELATION TO PINCH STRENGTH AND HAND DEXTERITY IN PRESCHOOL CHILDREN
Anemia is a major public health problem among preschool-aged children. The evidence demonstrated that early childhood anemia is a strong predictor of adulthood anemia (Gessner, 2009).
- Trial name
- IDA (NCT05959122)
- Testing
- CBC serum iron serum ferritin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University