Clinical trials: Metabolism Disorders
Childhood Obesity
Piloting a Family-Based Intervention of Time-Restricted Eating to Treat Obesity
This study will test whether managing the hours during which people eat, called time restricted eating, might help them to lose weight. For this study, one parent and a child will enroll as a group (called a dyad).
- Trial name
- NCT05107726
- Testing
- TRE Group
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Morbid Obesity
Six-month Study to Compare the Effects of Volume- and Pressure-Guided Adjustments on Weight Loss and Satiety
The purpose of this protocol is to determine how band fill volumes that are based on intraband pressure readings can influence the comfortability of the band and to compare weight loss with this methodology to weight loss with…
- Trial name
- NCT00960843
- Testing
- Intraband pressure recording system, Conventional Adjustment
- Where
- 2 sites in Australia, Czechia
- Volunteers
- 51 people
- Sponsor
- Ethicon Endo-Surgery
Diabetes, Diabetes Mellitus, Type 2
Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes
This trial is conducted globally. The aim of this trial is to investigate dose-finding of semaglutide administered subcutaneously once daily versus placebo and liraglutide in subjects with type 2 diabetes
- Trial name
- NCT02461589
- Testing
- semaglutide, liraglutide
- Where
- 150 sites in United States, Austria and 8 more
- Volunteers
- 706 people
- Sponsor
- Novo Nordisk A/S
Amyotrophic Lateral Sclerosis
Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis
A multicenter, open-label extension study to investigate the long-term safety of FAB122 in patients with Amyotrophic Lateral Sclerosis
- Trial name
- ADOREXT (NCT05866926)
- Testing
- FAB122
- Where
- Spain
- Volunteers
- 201 people
- Sponsor
- Ferrer Internacional S.A.
Hypertension, Dyslipidemias
Communicating Health Information and Improving Coordination With Primary Care
Survivors of childhood cancer are known to be at higher risk of developing premature, serious cardiovascular disease compared with the general population.
- Conditions
- Hypertension, Dyslipidemias, Diabetes, Childhood Cancer
- Trial name
- CHIIP (NCT03104543)
- Testing
- Education, Test results only
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- Fred Hutchinson Cancer Center
Hyperoxaluria
Hydroxyproline Influence on Oxalate Metabolism
Primary hyperoxaluria is an inborn error of metabolism that results in marked overproduction of oxalate by the liver. The excess oxalate causes kidney failure and can cause severe systemic disease due to oxalate deposition in…
- Trial name
- NCT02038543
- Testing
- Hydroxyproline and Leucine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Mucopolysaccharidosis I, Hurlers Syndrome
Clinical Study of Aldurazyme in Patients With Mucopolysaccharidosis (MPS) I
This study is being conducted to demonstrate the safety and clinical efficacy of Aldurazyme treatment in MPS I patients
- Conditions
- Mucopolysaccharidosis I, Hurlers Syndrome, Hurler-Scheie Syndrome
- Trial name
- NCT00912925
- Testing
- rhIDU (recombinant human-Alpha-L-Iduronidase)
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 45 people
- Sponsor
- Genzyme, a Sanofi Company
Vitamin D Deficiency, Vitamin D Insufficiency
Evaluating the Effect of SOLIUS UV Light Source in Improving Vitamin D Status
The aim of this study is to evaluate the safety and effectiveness of the SOLIUS System in improving serum levels of 25-hydroxyvitamin D in vitamin D deficient/ insufficient adults of various skin types.
- Trial name
- NCT04780776
- Testing
- UVB treatment
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Boston University
Diabetes, Hypertension
Combined Behavioral and Pharmacological Intervention for Cardiovascular Risk Reduction in Diabetic Patients
The purpose of this research is to study whether a multidisciplinary education in Diabetes and intervention for cardiac risk reduction in a group setting to modify patient behavior and adjust medications can achieve diabetes…
- Conditions
- Diabetes, Hypertension, Dyslipidemia, Coronary Arteriosclerosis
- Trial name
- NCT00357955
- Testing
- Behavioral counseling and peer support, Interactive Education, Role modeling
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Providence VA Medical Center
Obesity, Overweight
Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)
The purpose of this study is to determine the effects of NB relative to placebo on major adverse cardiovascular events (MACE) such as cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke in overweight and…
- Trial name
- NCT01601704
- Testing
- NB32, PBO, Weight Management Program
- Where
- 224 sites in United States
- Volunteers
- 8,910 people
- Sponsor
- Orexigen Therapeutics, Inc
Obesity, Weight Loss
Lifestyle Behavior Weight Loss Intervention
This lifestyle behavior intervention aims to weight loss in low-income overweight or obese mothers of young children through promotion of stress management, healthy eating, and physical activity.
- Trial name
- NCT04649047
- Testing
- Goal-oriented episodic future thinking
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Metabolic Syndrome, Hypertriglyceridemia
Niacin, N-3 Fatty Acids and Insulin Resistance
This research study is being conducted to test the effects of two drugs on blood lipids (cholesterol and triglycerides) and blood sugar (glucose) levels in patients with diabetes or "pre-diabetes" (both of which have a condition…
- Trial name
- NCT00286234
- Testing
- omega-3 acid ethyl esters, extended release niacin, combined treatment
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of South Dakota
Osteopenia, Arterial Hypertension
Comparative Effects of Moxonidine on Bone Metabolism, Vascular and Cellular Aging in Hypertensive Postmenopausal Women
This study evaluates the effect of moxonidine versus bisoprolol on collagen type 1 C-telopeptide in postmenopausal female patients with arterial hypertension and osteopenia.
- Trial name
- COMPASS (NCT02355821)
- Testing
- Moxonidine, Bisoprolol
- Where
- Russia
- Volunteers
- 114 people
- Sponsor
- National Research Center for Preventive Medicine
Diabetes, Pre-hypertension
Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects
The study will evaluate the effects of the direct renin inhibitor, aliskiren, on flow-mediated dilation of the brachial artery and on central aortic pressure in diabetic patients with pre-hypertension or Stage 1 hypertension.
- Conditions
- Diabetes, Pre-hypertension, Hypertension
- Trial name
- NCT01349114
- Testing
- aliskiren 300 mg once daily
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Alabama at Birmingham
Secondary Hyperparathyroidism
Etelcalcetide to Treat Secondary Hyperparathyroidism in Hemodialysis Patients With Chronic Kidney Disease-Mineral and Bone Disorder
The purpose of this study is to evaluate the effect of thrice weekly intravenous (IV) administration of etelcalcetide in the treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney…
- Trial name
- NCT01414114
- Testing
- Etelcalcetide
- Volunteers
- 37 people
- Sponsor
- KAI Pharmaceuticals
Postmenopausal Osteoporosis
A Safety and Efficacy Study to Evaluate Romosozumab (AMG 785) in South Korean Women With Osteoporosis
The primary objective is to evaluate the effect of treatment with romosozumab for 6 months compared with placebo on percent changes in bone mineral density (BMD) at the lumbar spine as assessed by dual-energy X-ray absorptiometry…
- Trial name
- NCT02791516
- Testing
- Romosozumab
- Where
- 10 sites in South Korea
- Volunteers
- 67 people
- Sponsor
- Amgen
Type 1 Diabetes
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
The objective of the proposed research is to evaluate the efficacy and safety of the use of metformin in addition to standard insulin therapy in overweight and obese children and adolescents, age 12-<20 years, with type 1…
- Trial name
- NCT01881828
- Testing
- Metformin (glucophage)
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Jaeb Center for Health Research
Pompe Disease
First-In-Human Study to Evaluate Safety, Tolerability, and PK of Intravenous ATB200 Alone and When Co-Administered With Oral AT2221
This is an international, multi-center, open-label study designed to evaluate if the co-administration of investigational new drugs ATB200 and AT2221 is safe in adults with Pompe disease.
- Trial name
- NCT02675465
- Testing
- ATB200, AT2221
- Where
- 19 sites in United States, Australia and 4 more
- Volunteers
- 29 people
- Sponsor
- Amicus Therapeutics
Congenital Adrenal Hyperplasia
A Ph2b to Evaluate Clinical Efficacy and Safety of Tildacerfont in Adult CAH
An investigation of the efficacy and safety of up to 70 weeks of treatment with Tildacerfont in subjects with classic CAH who have elevated biomarkers at baseline on their current GC regimen.
- Trial name
- NCT04457336
- Where
- 65 sites in United States, Australia and 18 more
- Volunteers
- 96 people
- Sponsor
- Spruce Biosciences
Amyotrophic Lateral Sclerosis
Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosis
The purpose of this study is to assess the safety and tolerability of clenbuterol (taken by mouth) in subjects with ALS (amyotrophic lateral sclerosis) and to assess the effectiveness of clenbuterol with regard to motor function…
- Trial name
- NCT04245709
- Testing
- Clenbuterol
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Dwight Koeberl, M.D., Ph.D.
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