Clinical trials: Metabolism and Elimination
Prediabetes
Glycemic Response to Two Doses of Low Sugar Apple Juice
Single center, double-blind, randomized controlled cross-over trial with four treatments and four time points. The study has three primary objectives.
- Trial name
- HB-RCT2-2015 (NCT04747639)
- Testing
- 500 ml glucose-depleted apple juice, 500 ml conventional apple juice, 250 ml glucose-depleted apple juice
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Clinical Research Center Kiel GmbH
Healthy
A Study to Assess the Absorption, Metabolism, and Routes of Excretion Following Oral Administration of (14C) Radiolabeled JNJ--42756493 to Healthy Male Participants
The purpose of this study is to assess the absorption, metabolism, and excretion of JNJ-42756493 in healthy male adult participants after administration of a single oral dose of 12 milligram (mg) of unlabeled JNJ-42756493 admixed…
- Trial name
- NCT02692677
- Testing
- JNJ-42756493
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Absorption, Metabolism
Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-Simufilam Following a Single Oral Dose in Healthy Male Subjects
To evaluate the absorption, metabolism, and excretion of [14C]-simufilam in healthy male subjects following a single oral administration of 100 mg of (approximately 100 µCi) [14C]-simufilam.
- Conditions
- Absorption, Metabolism, Excretion
- Trial name
- NCT06195319
- Testing
- Simufilam
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cassava Sciences, Inc.
Healthy Volunteers
A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Praliciguat in Healthy Male Volunteers
The primary objective is to characterize the pharmacokinetics (PK) of praliciguat and total radioactivity and to assess the elimination of total radioactivity from a single oral dose of [14C]-praliciguat.
- Trial name
- NCT03818295
- Testing
- [14C]-praliciguat
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cyclerion Therapeutics
Metabolism and Excretion
An Open-label, Single-dose Study to Determine the Metabolism and Excretion of [14C]E2006 in Healthy Male Subjects
The purpose of this study is to determine the metabolism and excretion of [14C]E2006 in healthy male subjects.
- Trial name
- NCT02046213
- Testing
- E2006
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Type 2 Diabetes
SGLT2 Inhibition: Uric Acid Excretion Study
The current study investigates the effects of SGLT2 inhibitor empagliflozin on uric acid excretion.
- Trial name
- UREX (NCT05210517)
- Testing
- Empagliflozin 25 MG, Benzbromaron, Empagliflozin 25 MG + benzbromarone 100 mg
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Amsterdam UMC, location VUmc
Healthy Volunteers
Radiolabeled Study of AG-221 in Healthy Male Subjects.
This is a single-center, 2-part, open-label study to evaluate the metabolism and excretion and absolute bioavailability of [14C]-AG-221 in healthy male subjects.
- Trial name
- NCT02443168
- Testing
- AG-221, 14C AG-221
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Celgene
Healthy
AZD0914 Phase 1 ADME Study in Healthy Volunteers
This study will investigate the metabolic fate and routes of excretion of 14CAZD0914 in six male healthy volunteers.
- Trial name
- NCT02298920
- Testing
- AZD0914
- Where
- 2 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Entasis Therapeutics
Healthy Participants, Obesity
A Study Investigating the Safety, Absorption, Elimination, and the Effect on the Immune System of ACI-19764 in Healthy Participants and in Participants With Cardiovascular Risk Factors
The main purposes of this study are: to investigate the safety and tolerability of ACI-19764 when it is administered to healthy participants and participants with cardiovascular risk factors to determine how quickly and to what…
- Conditions
- Healthy Participants, Obesity, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT07463196
- Testing
- ACI-19764 at dose A1, ACI-19764 at dose A2, ACI-19764 at dose A3
- Where
- Netherlands
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- AC Immune SA
Healthy Adults
A Study to Understand How the Body Processes [14C]PF-07104091 in Healthy Participants
The purpose of this study is to learn how the body processes the study medicine PF-07104091. The study is seeking participants who are: Healthy male aged 18 to 65 years of age Participants in the study will receive 14C-labeled…
- Trial name
- NCT07127770
- Testing
- PF-07104091
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cardiovascular Diseases
Absorption, Distribution, Metabolism and Excretion of [14C] Labelled BIA 5-1058
The purpose of the study is to determine the mass balance recovery in expired air, urine and faeces after a single oral dose of 400 mg 14C-labeled BIA 5-1058; to provide plasma, urine and faecal samples for metabolite profiling…
- Trial name
- NCT04069130
- Testing
- 400 mg of BIA 5-1058
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Healthy
Single-dose Study of [14C]PF-05221304 Metabolism and Excretion in Healthy Adult Male Subjects
The purpose of the study is to characterize the absorption, distribution, metabolism, and excretion (ADME) of a single oral dose of [14C]PF-05221304 in Healthy Adult Male Subjects
- Trial name
- NCT03448172
- Testing
- [14C]PF-05221304
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Participants
A Study to Evaluate the Drug Levels of BMS-986166 in Healthy Male Participants
The purpose of this study is to assess the drug levels of BMS-986166 in healthy male participants.
- Trial name
- NCT05409157
- Testing
- BMS-986166, Bisacodyl
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy Participants
A Study to Determine the Absorption, Metabolism, and Routes of Excretion of (14C) Radiolabeled Ibrutinib in Healthy Male Participants
The purpose of this study is to investigate the absorption, the metabolic pathways and the excretion of ibrutinib in healthy male adult participants after administration of a single oral dose of 50 mg to 140 mg (5 mg/mL solution)…
- Trial name
- NCT01674322
- Testing
- Ibrutinib
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Volunteers, Mass Balance Study
A Phase I, Open-Label, Single-Center Study to Assess the Absorption, Metabolism, and Excretion of [14C]-AZD3293
This study will be an open-label, non-randomized, absorption, metabolism, and excretion study to evaluate the mass balance, metabolite profiles, and rates and routes of elimination of [14C]-AZD3293 and derived metabolites…
- Trial name
- AZD3293hADME (NCT02126514)
- Testing
- AZD3293
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
What the Body Does to Foliglurax in Healthy Volunteers
This study evaluates how the body takes up and gets rid of foliglurax after swallowing a liquid dose.
- Trial name
- Foliglurax (NCT04002895)
- Testing
- Foliglurax
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Healthy
A Study Designed to See How [14C]-CORT125134 is Taken up, Broken Down and Removed From the Body
The study was designed to evaluate how CORT125134 is taken up, broken down and removed from the body when given as an oral capsule to healthy subjects.
- Trial name
- NCT03067376
- Testing
- [14C]-CORT125134
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Type 1 Diabetes Mellitus
Effect of CSII and CGM on Progression of Late Diabetic Complications
The purpose of the study is to investigate whether the combination of insulin pump therapy and continued glucose monitoring (CGM) is superior to multiple daily insulin injections to prevent progression of albuminuria in patients…
- Trial name
- NCT01454700
- Testing
- Insulin pump therapy (CSII) plus continuous glucose monitoring (CGM), Multiple daily insulin injections (MDI)
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Steen Andersen
Nutrition, Absorption, Metabolism and Excretion in Healthy Volunteers
Bioavailability of Omega-3 Fatty Acids From Fish Oil Supplements
This study is investigating whether a new type of fish oil supplement, in the form of soft chews, leads to better absorption of omega-3s in the body compared to traditional fish oil capsules.
- Conditions
- Nutrition, Absorption, Metabolism and Excretion in Healthy Volunteers, Fish Oils, Omega 3 Fatty Acids
- Trial name
- Ocean's O3 (NCT06665464)
- Testing
- Fish oil supplement 1, Fish oil supplement 2
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Healthy Volunteer Study
Mass Balance Study of AT-527 in Healthy Adult Male Subjects (R07496998)
Mass balance study of AT-527 in Healthy Male Subjects.
- Trial name
- NCT05004415
- Testing
- AT-527 (R07496998)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.