Clinical trials: Metabolism and Elimination
Healthy
A Single-Radiolabeled Dose Mass Balance Study To Investigate The Absorption, Metabolism, And Excretion Of [14C] Palbociclib (PD-0332991) In Healthy Male Volunteers
This will be an open-label, single-center study to evaluate the mass-balance and pharmacokinetics of PD-0332991 in approximately 6 healthy male subjects receiving a single oral 125 mg dose of PD-0332991 containing approximately…
- Trial name
- NCT01756768
- Testing
- [14C]-PD-0332991
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteer, Muscular Dystrophies
Absorption, Metabolism, Excretion and Absolute Bioavailability of EDG-5506 in Healthy Volunteers
This is a Phase 1 2-part, single-center, open-label study in healthy male volunteers. Part A will assess the absorption, metabolism, excretion, and pharmacokinetics of one oral dose of radiolabeled EDG-5506.
- Conditions
- Healthy Volunteer, Muscular Dystrophies, Muscular Disorders, Atrophic, Muscular Diseases
- Trial name
- NCT05730842
- Testing
- EDG-5506 Tablet, Radiolabeled EDG-5506 Suspension, Radiolabeled EDG-5506 Intravenous
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Edgewise Therapeutics, Inc.
Healthy Volunteers
Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-BGB-3111 in Healthy Males
Phase 1 study in healthy subjects to determine the effect of an 8-hour fast from food on the pharmacokinetics of [14C]-BGB-3111.
- Trial name
- NCT04163783
- Testing
- [14C]-BGB-3111, BGB-3111
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BeiGene
Healthy
Study to Assess the Absorption, Metabolism, Excretion and Pharmacokinetics of [14C]-AKB-9778
Open-label, single-dose, Phase 1 study to assess the absorption, metabolism, excretion and pharmacokinetics of [14C]-AKB-9778 in healthy male volunteers
- Trial name
- NCT02858271
- Testing
- AKB-9778 subcutaneous injection
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Aerpio Therapeutics
Gaucher's Disease Type I
A Study to Evaluate Absolute Bioavailability, Absorption, Metabolism, and Excretion of Genz-112638 in Healthy Male Participants
Objectives: To determine pharmacokinetic (PK) variables, including absolute bioavailability (F), of Genz-99067, the free base of the L-tartaric acid salt of Genz-112638 as it exists in plasma, after a single intravenous (IV) dose…
- Trial name
- NCT06143904
- Testing
- Genz-112638, [14C]-Genz-112638
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy Volunteers
A Study of the Absorption, Metabolism, and Excretion of [14C]-Fosgonimeton (ATH-1017)
This is a Phase 1, open-label, nonrandomized, single-dose human, absorption, metabolism, and excretion study of [14C]-Fosgonimeton
- Trial name
- NCT05511558
- Testing
- [14C]-Fosgonimeton
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- LeonaBio
Non-alcoholic Fatty Liver Disease, Morbid Obesity
Ursodeoxycholic Acid in Bariatric Surgery
In an open-label trial, 20 otherwise healthy morbidly obese patients scheduled for bariatric surgery will be administered 20 mg/kg/day ursodeoxycholic acid for three weeks until the day before surgery.
- Trial name
- NCT01548079
- Testing
- Ursodeoxycholic Acid (UDCA)
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Healthy
Effects of Kava on the Body's Elimination of Caffeine and Dextromethorphan
This study will examine how kava-a widely used herbal remedy-may affect the body's elimination of other medicines. Many people take kava to reduce anxiety or cause sedation.
- Trial name
- NCT00009542
- Testing
- kava (Piper methysticum)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Chronic Kidney Failure, End-stage Renal Disease
Fosrenol and Phosphorus Balance - Lanthanum Carbonate
Positive phosphorus balance and hyperphosphatemia (increased serum phosphorus levels) are very common complications of people with advanced chronic kidney disease (i.e., stage 5 CKD), including chronic dialysis patients, and are…
- Conditions
- Chronic Kidney Failure, End-stage Renal Disease, Disorders Associated With Peritoneal Dialysis
- Trial name
- NCT01581996
- Testing
- lanthanum carbonate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Solid Tumours
Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers
To evaluate the absorption, distribution, metabolism and excretion (ADME) of single dose [14C] selumetinib in volunteers
- Trial name
- NCT01931761
- Testing
- [C14] selumetinib (oral)
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Fungal Infection
ADME Study of [14C]-Ibrexafungerp in Healthy Male Subjects
This is a Phase 1, open-label, single-centre, non-randomised study to evaluate the absorption, distribution, metabolism, and excretion (ADME) of an oral solution of [14C]-ibrexafungerp following administration in healthy male…
- Trial name
- NCT04307082
- Testing
- [14C]-Ibrexafungerp
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Scynexis, Inc.
Healthy Male Subject
Study of Absorption, Metabolism and Excretion Following a Single Oral Dose of [14C]KWA-0711 to Healthy Male Subjects
The purpose of this study is to evaluate the absorption, metabolism and excretion following a single oral dose of [14C]KWA-0711 to healthy male subjects.
- Trial name
- NCT02434835
- Testing
- [14C]KWA-0711
- Where
- United Kingdom
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Healthy
A Mass Balance Study to Investigate the Absorption, Metabolism, and Excretion of [14C]Sulfatinib
This is a single-center, open label and single-dose clinical trail, to explore the body mass balance and identify the major metabolites in Chinese adult male healthy volunteers after a single oral dose of [14C]Sulfatinib, to…
- Trial name
- NCT03627520
- Testing
- [14C]Sulfatinib
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hutchison Medipharma Limited
Fabry Disease
A Study to Assess the Absorption, Metabolism and Excretion of Migalastat Hydrochloride (AT1001-014)
This study is designed to describe the metabolism of AT1001 (migalastat HCl) and the contribution of metabolism and urinary excretion to its overall elimination as part of the continuing assessment of the safety and effectiveness…
- Trial name
- NCT01730482
- Testing
- [14C] AT1001
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Amicus Therapeutics
Appetite Regulation
The Effect of Dietary Fibre and Plant Protein on Appetite and Metabolic Function
Acute effects on appetite and metabolic function have been observed for whole-grain rye cereal products. The aim of this study is to evaluate if the appetite suppressing effect of a whole-grain rye breakfast cereal may be further…
- Trial name
- NCT01965210
- Testing
- Rye + high dose inulin + low dose gluten, Rye + equal doses of inulin & gluten, Rye + low dose inulin + high dose gluten
- Where
- Sweden
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Swedish University of Agricultural Sciences
Healthy Adult Male
Absorption, Metabolism, Excretion, and Mass Balance Study of [14C]-VVZ-149 in Healthy Adult Male Subjects
This is an open-label, single-dose, absorption, metabolism, excretion, and mass balance study following a single IV infusion of [14C]-VVZ-149 in healthy adult male subjects.
- Trial name
- NCT04415645
- Testing
- [14C]-VVZ-149
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vivozon, Inc.
Healthy
A Study to Investigate the Metabolism and Excretion of [14C]-TRV130 in Healthy Male Subjects
The purpose of this study is to determine the routes of excretion for TRV130 and it's metabolites, and to determine and characterize, structurally, the metabolites present in plasma, urine, and feces in healthy male subjects.
- Trial name
- NCT02169934
- Testing
- Radiolabeled TRV130
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Trevena Inc.
Cancer
An Absorption, Distribution, Metabolism and Excretion (ADME) Study of Single Oral Dose [14C] GSK2118436 in Subjects With BRAF Mutant Solid Tumors
The study is a Phase 1, open-label study designed to characterize the absorption, distribution, metabolism and excretion of GSK2118436 following administration of a single oral 14C labeled dose of GSK2118436 as a suspension in…
- Trial name
- NCT01262963
- Testing
- GSK2118436
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- GlaxoSmithKline
Healthy
Single Oral Dose of 60 mg [14C]AZD9668 in Healthy Male Volunteers
The purpose of the study is to characterise the absorption, distribution, metabolism and excretion (ADME) of a single oral dose of [14C]AZD9668.
- Trial name
- ADME (NCT01147549)
- Testing
- [C14]AZD9668
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Food Matrix Effect on Flavanol Absorption, Metabolism and Excretion: Methylxanthines
Dietary intervention study in healthy young adult males to evaluate concentration of flavanol metabolites in plasma and urine after single acute intakes of methylxanthines.
- Trial name
- NCT03526107
- Testing
- CF Control, CF-Theobromine, CF-Caffeine
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis