Clinical trials: Metabolite
Healthy
A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants
A total of approximately 12 healthy male or female participants will be enrolled in the study so that at least 10 participants will complete the study.
- Trial name
- NCT03937258
- Testing
- PF-04965842, Probenecid
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Total-body Irradiation, Hematopoietic Stem Cell Transplant
Radiation Biodosimetry in Children Undergoing Total Body Irradiation
The purpose of this study is to develop fecal tests that will determine the extent of radiation exposure in patients undergoing radiation treatment for cancer.
- Trial name
- NCT01337648
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Medical College of Wisconsin
Pharmacokinetics
Pharmacokinetics Study: Determination of Naproxcinod and Its Metabolites After Oral Administration in Male
This study will be performed in 2 parts conducted in parallel: Part 1 (conducted on 16 healthy subjects): Administration of naproxcinod 750 mg or naproxen 500 mg twice a day (bid) during 7 days The main aim of this study part…
- Trial name
- NCT01404598
- Testing
- naproxcinod 750 bid, naproxcinod 3000 mg od, naproxen 500 mg bid
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NicOx
Ovarian Carcinoma
Metabolite Levels in Ovarian Cancer Patients Receiving Maintenance PARP Inhibitors
This study evaluates blood samples and compares levels of metabolites (levels of vitamins, carbohydrates, proteins, etc., that are in the blood), before and after the plasma exchange in patients scheduled to receive immunotherapy…
- Trial name
- NCT04917744
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis, Medical Chart Review
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Healthy
Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2
The goal of this trial is to investigate the biological effects of oral supplementation with indole-3-propionic acid (IPA) taken twice daily in healthy adults.
- Trial name
- iPROACT-pilot2 (NCT07105514)
- Testing
- Indole-3-propionic acid (IPA)
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Cardiodynamics, Safety
Study of Selexipag and Its Metabolite ACT-333679 on Cardiac Repolarization in Healthy Male and Female Subjects
This is a single-center, double-blind, randomized, placebo- and positive-controlled, double-dummy, parallel-group, multiple-dose, up-titration study with a nested cross-over comparison between moxifloxacin and placebo in healthy…
- Conditions
- Cardiodynamics, Safety, Tolerability, Pharmacokinetics
- Trial name
- NCT02206204
- Testing
- selexipag, moxifloxacin
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Actelion
Healthy Males
Evaluation of the PK Profile of Firibastat Following Administration of Firibastat Prototype Tablet Formulations
This is a single-centre, open-label, non-randomised, period fixed sequence study designed to investigate the PK and safety of Firibastat (QGC001) modified release (MR) prototype tablet formulations and compare this to a reference…
- Trial name
- NCT03714685
- Testing
- Firibastat
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Quantum Genomics SA
Prediabetes, Type-2 Diabetes
Dietary Intervention Replacing Carbohydrate With Protein and Fat Has Greater Effect on Peripheral Blood Mononuclear Cell Metabolites Than on Plasma Metabolites in Patients With Prediabetes or Type-2 Diabetes
This study examined whether dietary-induced reductions in lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in peripheral blood mononuclear cells (PBMC) and plasma affected metabolic profiles in PBMCs and plasma.
- Trial name
- NCT02191644
- Testing
- Dietary intervention-refined rice, Dietary intervention-whole grains and legumes
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Healthy
Crossover Drug-Drug Interaction Study to Determine Effects of Cytochrome P450 3A on Exposure to Mifepristone and Its Metabolites
This is a Phase 1, single center, fixed sequence, open label, drug-drug interaction study of the effect of multiple doses of rifampin 600 mg daily, a strong CYP3A inducer, on the exposure of mifepristone at 2 dose levels.
- Trial name
- NCT03258372
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Healthy
Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy Participants
The purpose of this study was to assess the effect of multiple doses of itraconazole on single dose tepotinib pharmacokinetics in healthy participants.
- Trial name
- NCT05203822
- Testing
- Tepotinib (HydroChloride hydrate), Itraconazole
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Pressure Ulcers
Effect of an Oral Supplement Enriched in Amino Acids and the Leucine Metabolite B-hydroxy B-methylbutyrate (HMB)
The focus of this study is to look at the role of nutrition in the healing of pressure ulcers. The purpose of this study is to test whether the rate of healing of pressure ulcers is increased in those patients receiving a…
- Trial name
- NCT00502372
- Testing
- Nutritional Supplement/Amino acids and HMB, Juven
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Central Arkansas Veterans Healthcare System
Inflammatory Bowel Disease, Crohn's Disease
The Impact of 6MP Metabolite Levels on Infliximab Pharmacokinetics and Anti-infliximab Antibodies in Crohn's Disease
In this research proposal, the investigators will focus on methods to optimize the therapeutic response to anti-TNF antibodies, by determining a correlation of 6-mp metabolite levels with IFX trough levels, anti-IFX antibody…
- Trial name
- NCT02453607
- Testing
- Infliximab, thiopurine
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Ernest Seidman
Hypertensive Disorder of Pregnancy
Microbial Metabolites and Outcomes of Pregnancy Study
Emerging data connect diet, the gut microbiota and its metabolites in cardiometabolic disease. Hypertensive disorders of pregnancy (HDP) are common and are a leading cause of maternal and neonatal morbidity.
- Trial name
- MMOPS (NCT06362356)
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- The Cleveland Clinic
Alzheimer's Disease
Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers
Rilapladib is a potent and selective inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), which was previously under development for the treatment of atherosclerosis and is currently being developed for the treatment…
- Trial name
- NCT02130661
- Testing
- Rilapladib 25 mg, Rilapladib 250 mg, Itraconazole
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Subarachnoid Hemorrhage, Aneurysmal
Angiotensin Metabolite Profile After Subarachnoid Hemorrhage
The outcome of subarchnoid hemorrhage depends on the severity of the bleeding and the development of secondary neurologic deficits caused by cerebral vasospasm.
- Trial name
- NCT05222542
- Testing
- Sampling of plasma and cerebrospinal fluid at specified time points
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Dr. Roman Ullrich
Healthy
Pharmacotoxicology of Trichloroethylene Metabolites
This is a research study to look at how Dichloroacetate (DCA), and investigational drug and chloral hydrate are broken down in the body.
- Trial name
- NCT01128270
- Testing
- Dichloroacetate environmental dose, Chloral Hydrate environmental dose, Dichloroacetate therapeutic dose
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Florida
Coronary Artery Disease
Biomarkers for Cardiovascular Disease
Biomarkers for Cardiovascular Disease Summary: This study will examine the function of the lining cells of blood vessels and measure substances in the blood to see how they relate to various blood tests, including new tests under…
- Trial name
- NCT00109018
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Major Depressive Disorder (MDD)
Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation.
This is a case control study including simple random cases of 90 persons, 45 of them have depressive disorders and the other 45 are healthy individuals,age group between 18-60 years old, cases will be recruited from outpatient…
- Trial name
- NCT07771517
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Abiraterone Acetate, Gene Polymorphism
Effects of Metabolic Enzymes and Transporter Gene Polymorphisms on the Pharmacokinetics and Metabolism of Oral Abiraterone Acetate in Healthy Chinese Adults
1. To explore the relationship between the changes of plasma concentration of abiraterone acetate after taken orally on fasting or postprandial and gene polymorphism. 2.
- Conditions
- Abiraterone Acetate, Gene Polymorphism, Pharmacokinetic, Metabolic Analysis
- Trial name
- NCT04735913
- Testing
- Abiraterone acetate tablets
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Aortic Stenosis
Role of Elastin Metabolites in Aortic Remodelling in AS
Around 1-2% of people are born with a 'bicuspid' aortic valve, with only two cusps instead of the common 'tri-leaflet' valve. People with this valve develop dysfunction of the valve (narrowing or leakage) at a much earlier age.
- Trial name
- ELASTIC-AS (NCT03883490)
- Testing
- ECG, Blood test and biobanking, Trans-thoracic Echocardiogram
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Leicester