Clinical trials: Metabolome
HIV, Non-Alcoholic Fatty Liver Disease
The Gut, Liver And Metabolome in Human Immunodeficiency Virus and Non Alcoholic Fatty Liver Disease
Persons with human immunodeficiency virus (HIV) have higher risk of developing fatty liver disease (NAFLD) than HIV-negative persons but the reasons for this discrepancy are not known.
- Conditions
- HIV, Non-Alcoholic Fatty Liver Disease, Metabolic-Associated Steatotic Liver Disease
- Trial name
- GLAM HIV NAFLD (NCT06113003)
- Testing
- Prebiotic, Probiotic
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Vanderbilt University Medical Center
Overactive Bladder
Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients
This is a non-interventional study that will not pose any burden for the participants. The study subjects will be examined and treated in a standard manner according to current clinical recommendations for the treatment of…
- Trial name
- NCT06921746
- Testing
- Urine Microbiological and Metabolomic Analysis
- Where
- 4 sites in Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Ostrava
Aspirin, Microbiota
Influence of Aspirin on Human Gut Microbiota Composition and Metabolome
Colorectal cancer (CRC) is the third most common cancer type in males and the second in females, accounting for about 693,900 deaths worldwide per year.
- Trial name
- NCT03450317
- Testing
- Aspirin 80mg
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Type 1 Diabetes Mellitus Maturity Onset
Altered Faecal Microbiome and Metabolome in CT1D, AT1D and T2D
To elucidate the characteristics of global gut microbiota and fecal/serum metabolites in patients with childhood-onset type 1 diabetes, adult-onset type 1 diabetes or type 2 diabetes.
- Trial name
- NCT05252728
- Where
- China
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Liver Cirrhosis
To Evaluate the Feasibility of Collecting Duodenal Fluid With SIMBA Capsules
In this study, the feasibility to use SIMBA (Small Intestinal MicroBiome Aspiration) capsules to collect small intestinal microbiome and metabolome information will be evaluated in patients with liver cirrhosis.
- Trial name
- CAP (NCT06708832)
- Testing
- SIMBA ingestion
- Where
- Austria
- Volunteers
- 11 people
- Sponsor
- Vanessa Stadlbauer-Koellner, MD
Gallstone Disease, Bile Duct Diseases
Gut Microbiome and Metabolome in Patients With Gallstone Disease After Surgical and Endoscopic Interventions
The goal of this longitudinal observational cohort study is to examine the changes in the composition and diversity of gut microbiome and systemic metabolome in patients with symptomatic gallbladder stones with or without…
- Trial name
- NCT05689255
- Where
- Singapore
- Volunteers
- 65 people
- Sponsor
- Changi General Hospital
Acute Lymphoblastic Leukemia, Nutrition Aspect of Cancer
InterNatIonal CHildhood Leukemia Microbiome/MEtabolome Cohort
Nutritional status is a measurable and modifiable factor that is often not considered during treatment and its clinical impact undervalued due in part to the heavy demands on clinicians in low and middle income countries to…
- Conditions
- Acute Lymphoblastic Leukemia, Nutrition Aspect of Cancer, Microtia, Genetic Predisposition
- Trial name
- NICHE (NCT05929976)
- Testing
- No intervention
- Where
- 8 sites in United States, Brazil and 4 more
- Volunteers
- 4,900 people
- Sponsor
- Columbia University
Irritable Bowel Syndrome, Abdominal Pain
Impact of a Yoga Intervention on Pain and Multiomics in Participants With IBS
The purpose of this research study is to see if a six-week yoga program delivered online/virtually via Zoom, reduces abdominal pain in people with irritable bowel syndrome (IBS).
- Trial name
- NCT04315714
- Testing
- Yoga Program
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Gut Microbiota, Metabolic Profiles
Gut Microbiome-Metabolome Profiling in H. Pylori-SIBO Comorbidity
Patients with concurrent Helicobacter pylori infection and small intestinal bacterial overgrowth (SIBO) represent a clinically challenging subgroup, often experiencing refractory gastrointestinal symptoms and diminished treatment…
- Conditions
- Gut Microbiota, Metabolic Profiles, Helicobacter Pylori Infection, Small Intestinal Bacterial Overgrowth
- Trial name
- NCT07122284
- Testing
- 13C-Urea Breath Test, Hydrogen-Methane Breath Test
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Zhongshan Hospital (Xiamen), Fudan University
Healthy
Pre-analytical Sample Handling Conditions and Their Effects on the Human Serum Metabolome
This study evaluates how blood serum handling conditions can affect the concentrations of ~1,000 serum metabolites and attempts to quantify the degree of attenuation and/or potential bias in epidemiologic associations that may…
- Trial name
- NCT02697500
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center