Clinical trials: Metabolomics
Obesity, Brain Function
Food Intake-Related Brain and Metabolic Responses in Obesity
This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled.
- Conditions
- Obesity, Brain Function, Metabolomics, Feeding Behavior
- Trial name
- NCT07392905
- Testing
- Glucose Liquid Meal, Fat Liquid Meal, Protein Liquid Meal
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Asthma
Metabolomic Analysis of Exhaled Breath Condensate in Asthmatics
Asthma is a chronic inflammatory airway disease. Significant heterogeneity exists in the clinical manifestations and treatment responses in these patients.
- Trial name
- NCT01439737
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Coronavirus Infection, Covid19
Renal Biomarkers in AKI and COVID-19
Severe pneumoniae related to Coronavirus Disease (COVID-19), had a high in-hospital mortality; this condition are worst in subjects with acute kidney disease (AKI); conditioning increased mortality, days of assisted mechanical…
- Conditions
- Coronavirus Infection, Covid19, SARS (Severe Acute Respiratory Syndrome), AKI
- Trial name
- NCT04517630
- Testing
- urinary NGAL, TIMP-2, IGFBP7, IL-6, viral load and metabolomic
- Where
- Mexico
- Volunteers
- 51 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Adenoid Hypertrophy, Tonsillar Hypertrophy
Metabolomic Profiling of Racial Disparity
Tonsillectomy ± adenoidectomy (T\&A) is one of the most common surgical operations with over 500,000 pediatric T\&As performed annually in the United States.
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Surgery
- Trial name
- NCT06266429
- Testing
- Blood collection
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Nationwide Children's Hospital
Endometriosis
Role of Metabolomics in the Diagnosis of Endometriosis
Endometriosis is one of the most common benign gynecological, affecting about 10% of premenopausal women. The pathophysiology of this disease is still not completely clear.
- Trial name
- NCT02337816
- Testing
- laparoscopic surgery, obtainment of biological samples
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Sarcoma
Pharmacometabolomic of Trabectedin in Soft Tissue Patients
This perspective, mono institutional study is addressed to find potential serum and urine biomarkers predictive of the pharmacokinetic and pharmacodynamic profile of soft tissue sarcomas patients treated with trabectedin.
- Trial name
- Metabol-STS (NCT04394728)
- Testing
- Trabectedin
- Volunteers
- 44 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Human Metabolomic Responses to Plant Foods, Blood Pressure
Establish a Vegetable Signature Database From Human Metabolomics Responses
Vegetable is well known to prevent chronic disease,however, the mechanism of its nutrients and non-nutrients still remains to be discovered.We design a feeding study which provides plant foods to subjects one by another and…
- Trial name
- NCT01600911
- Testing
- Low phytochemical diet(LPD), high phytochemical diet(HPD)
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Healthy Volunteer
Sucralose as a Way to Enhance Regulatory T Cells
Title: Taking the SWEET approach to protect the transplanted kidney. Background: Kidneys are essential organs in our body. When they do not work, patients require machines to help them or receive a new kidney from a donor…
- Trial name
- SWEET (NCT06997133)
- Testing
- sucralose
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Caroline Lamarche
Severe Malaria
Severe and Cerebral Malaria Investigated Through Host Metabolomics
The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies. Despite treatment between 10-30% of patients with severe malaria die.
- Trial name
- NCT02451904
- Testing
- Observation
- Where
- Bangladesh
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Central Hypothyroidism, Hypothyroidism
Metabolomics of Thyroid Hormones
The aim of this study is to develop a metabolome signature of thyroid hormone status. The metabolome signature could be useful in diagnosis and treatment of thyroid dysfunction diseases, especially in cases where TSH cannot be…
- Conditions
- Central Hypothyroidism, Hypothyroidism, Hyperthyroidism
- Trial name
- MATcH (NCT03823859)
- Testing
- Indirect calorimetry, Dual energy X-ray Absorptiometry (DXA), Blood sampling
- Where
- Switzerland
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Dysbiosis, Cardiometabolic Health Indicators
Almonds, Gut Microbiome and Kids
This 8-week parallel-arm randomized controlled trial (N=70; ages 6-13) will determine the impact of daily almond butter consumption on gut microbiome composition and function, intestinal barrier integrity, and cardiometabolic…
- Trial name
- NCT07636850
- Testing
- Creamy Richards 100% Almonds! Creamy Natural Almond Butter, Cadbury Milk Chocolate Spread
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida State University
Facioscapulohumeral Muscular Dystrophy
Unraveling Metabolic Involvement in Facioscapulohumeral Dystrophy Through Metabolomics
The pathogenesis of facioscapulohumeral dystrophy (FSHD), one of the most prevalent types of inherited muscle disease, is unknown.
- Trial name
- METIN-FSHD (NCT06086548)
- Testing
- metabolomic on plasma sample
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Study on the Use of Traditional Chinese Medicine Diagnostic Tools to Assist in Identifying the Clinical Characteristics of Inflammatory Bowel Disease and Research on Metabolic Plastids of Tongue Coating
This study will be conducted at the outpatient clinic of China Medical University hospital. It is expected to enroll two groups of 30 subjects, including the experimental group must meet the clinical diagnosis of IBD, and the…
- Trial name
- NCT07314151
- Testing
- No intervention (observational study with diagnostic assessments only)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Healthy Adult Participants
Effects of Coca-Cola Zero Sugar Consumption on Urinary Metabolites in Healthy Adults
Consumption of beverages containing non-nutritive sweeteners has increased worldwide, but limited information is available regarding the short-term urinary excretion of acesulfame potassium (Ace-K) and the acute metabolic…
- Trial name
- NCT07694401
- Testing
- Coca-Cola Zero Sugar, Still water
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Czech University of Life Sciences Prague
Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis
Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple Sclerosis
The goal of this clinical trial is to learn whether a structured lifestyle program can improve health and wellbeing in people living with multiple sclerosis (MS).
- Trial name
- HEAL-MS (NCT07589062)
- Testing
- Multi-Domain Lifestyle Intervention
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- New York University Abu Dhabi
Heart Transplant Rejection
Cardiac Transplant Metabolomics With and Without Rejection
Patient who received a heart transplant may develop organ rejection. Currently, an invasive biopsy of the heart needs to be performed to diagnose rejection.
- Trial name
- ANTIPARTICLE (NCT05772442)
- Testing
- Extra blood samples (5-10 mL) drawn
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Oncology
New Biomarkers in Pancreatic Cancer Using EXPEL Concept
The investigators recently engineered a novel biomarker discovery approach that is non-destructive and fully compatible with OMICS profiling as well as routine clinical procedures (5).
- Trial name
- PANEXPEL (NCT03791073)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Pre-diabetes, Obesity
Stanford Kids CAMP Study
The Stanford Kids CAMP study aims to evaluate the feasibility of enrolling minority participants in school age children (5-13 years old) in a community summer camp setting along with the efficiency by which each participant's…
- Conditions
- Pre-diabetes, Obesity, Type-2 Diabetes Mellitus
- Trial name
- NCT05380817
- Testing
- Remote Monitoring Program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Atherosclerosis
Investigating the Gut Microbiota Modulation Effects of Allicin for Cardiovascular Disease Protection and Establishing Microbiota Directed Personalized Nutrition Guidance With Novel Humanized Gnotobiotic Mice Model, Microbial Culturomics and Metabolomic Technique
Investigators recruited 10 trimethylamine N-oxide (TMAO) producers to test the effect of garlic juice containing allicin on gut microbiota modulation and TMAO production.
- Trial name
- NCT04545879
- Testing
- Raw garlic juice containing allicin
- Where
- Taiwan
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy
Biomarker pAtterns Reflecting habITual fOod iNtakE: the BARITONE Project
The BARITONE study's overall aim is to understand how our eating habits affect our long-term health. By identifying biological traces in blood, urine and other samples - so-called biomarkers - the investigators want to be able to…
- Trial name
- BARITONE (NCT07128940)
- Testing
- Meat vs fish, Meat vs Vegetarian, Fish vs Vegetarian
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Göteborg University