Clinical trials: Metabolomics
Congenital Heart Disease, Metabolism Disorder
Metabolic Remodeling in Fontan Patients
Assessment of metabolic alterations in adult Fontan patients with a dominant left ventricle with the help of serum examinations (Metabolomics).
- Trial name
- NCT03886935
- Testing
- Metabolomics
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Menopause, Postmenopausal Disorder
Metabotyping in the Postmenopausal Stage
Menopause is defined as the absence of menstrual periods for twelve consecutive months. Although the onset may vary, natural menopause occurs between the ages of 45 and 55 and is considered a stage in the aging process for women.
- Conditions
- Menopause, Postmenopausal Disorder, Postmenopausal Symptoms
- Trial name
- SHE-HEALTH (NCT05397015)
- Testing
- No intervention will be done
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Tumor, Cardiovascular
Decoupling Immunotherapy Toxicity and Cancer Response
This study is a novel evaluation of cardiotoxicity after ICI therapy based on traditional CV risk factors with the addition of metabolomic profiles, epigenetic aging, and CHIP.
- Trial name
- NCT07382752
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- M.D. Anderson Cancer Center
Heart Failure, Pulmonary Hypertension
Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure
Heart failure (HF) patients often develop pulmonary hypertension (PH) that leads to transition into a biventricular HF with poor prognosis.
- Conditions
- Heart Failure, Pulmonary Hypertension, Pulmonary Vascular Resistance Abnormality
- Trial name
- LUNG-HF (NCT06331208)
- Testing
- non-contrast chest CT, spirometry with diffusing lung capacity for carbon monoxide (DLCO) analysis, Omics analysis of blood plasma obtained from pulmonary artery or peripheral blood
- Where
- Czechia
- Volunteers
- 230 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Biological Markers, Diet, Healthy
Dietary Biomarkers Intervention Core
The purpose of this controlled feeding trial is to establish an Intervention Core, equipped to perform tightly controlled pharmacokinetic (PK) and dose-response (DR) feeding studies.
- Conditions
- Biological Markers, Diet, Healthy, Metabolomics, Nutrition, Healthy
- Trial name
- NCT05616585
- Testing
- Pharmacokinetic (PK)- Controlled Feeding Diet, Dose Response (DR)- Controlled Feeding Diet
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Patients With AERD Undergoing Aspirin Desensitization
The Metabolomics of Anaphylaxis
Metabolomics is the study of metabolic pathways and the unique biochemical molecules which result from the regulatory response to physiological stressors, disease processes, or drug therapy.
- Trial name
- NCT01666275
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Heart Failure
Cardiac Rehabilitation and Metabolomics in Heart Failure
This is a randomized controlled trial of participants with heart failure randomized into usual care plus integrated cardiac rehabilitation or usual care only.
- Trial name
- CROMe (NCT03743012)
- Testing
- Integrated cardiac rehabilitation, Usual Care
- Where
- Kenya
- Volunteers
- 91 people
- Sponsor
- Duke University
Ischemic Heart Disease
Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT
The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test…
- Trial name
- METS (NCT02968771)
- Testing
- Non intervention
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Aged
Clinical Trial to Investigate Pharmacokinetics, Metabolomics and Biomarker in Elderly After UDCA Administration
A clinical study to investigate pharmacokinetics, metabolomics and biomarker in healthy elderly subject after ursodeoxycholic acid administration
- Trial name
- NCT02789644
- Testing
- Ursodeoxycholic Acid
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Bladder Cancer
Establishment and Validation of an Early Diagnostic Model for Bladder Cancer Based on Serum and Urine Metabolomics
Metabolomics is a complementary approach for identifying perturbed metabolic pathways. The goal of this study is to establish and validate an early diagnostic model for bladder cancer by metabolomics.
- Trial name
- NCT04966962
- Testing
- serum and urine metabolomics
- Volunteers
- 180 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Myocardial Infarction (AMI)
POCT Detection for Blood Concentration of Tirofiban in Acute Myocardial Infarction Based on Azo-POP Probe.
The goal of this observational study is to monitor blood drug concentration during the use of tirofiban, predict the occurrence of intraoperative and postoperative complications related to interventional therapy, and evaluate the…
- Trial name
- NCT06836531
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Health, Bile Acid Synthesis Disorders
Bile Acids As Determinants of Postprandial Metabolism
This study aims to understand how bile acids (BAs) appear in the bloodstream after eating and how this might affect inflammation and metabolism.
- Conditions
- Health, Bile Acid Synthesis Disorders, Postprandial Metabolism, Postprandial Lipids Metabolism
- Trial name
- PRIME (NCT06758453)
- Testing
- Dietary Challenge
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Major Depression Disorder
Molecular Signatures of TMS Response in Treatment-Resistant Depression
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option for treatment-resistant depression (TRD).
- Trial name
- PROMET_TMS (NCT07039370)
- Testing
- TMS
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Early Breast Cancer, Neoadjuvant Treatment
Impact of "Targeted" Nutritional Apport and Exercise on the Modulation of Metabolic and Immune-related Gene Expression Signatures in Early Breast Cancer (eBC) Patients Candidate to Neoadjuvant Therapy (NAT)
NEOMET is an exploratory randomized prospective, multicenter study whose primary aim is to explore if metabolomic signatures can be modified by a lifestyle intervention including dietary supplements and physical exercise…
- Trial name
- NEOMET (NCT06928701)
- Testing
- omega-3 (n-3 Lc-PUFA), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) plus a source of palmitoleic acid (hexadecenoic acid)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Eastern Piedmont
Heart Transplant
Observational Study With Additional Procedures: Metabolomic and Ultrastructural Findings of Allograft in Heart Transplantation and Their Correlation With Graft Dysfunction.
This is a single center retrospective/prospective observational study with additional procedures meant to evaluate molecular mechanisms underlying injury in donor's heart.
- Trial name
- MetabolHeart (NCT07125703)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Myeloproliferative Disease, Polycythemia Vera
ENERGIA: Personalized Exercise Program for Fatigue in Patients With Myeloproliferative Neoplasms and Chronic Myeloid Leukemia
This study evaluates whether a personalized, supervised exercise program can improve fatigue and physical function in patients with myeloproliferative neoplasms (MPN) and chronic myeloid leukemia (CML).
- Conditions
- Myeloproliferative Disease, Polycythemia Vera, Thrombocythemia Essential, Myelofibrosis, Primary
- Trial name
- ENERGIA (NCT07518940)
- Testing
- Participants will take part in a 12-week exercise program that includes aerobic and resistance training, tailored to their individual fitness level and clinical condition.
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Carmen Fava
Breast Cancer
Effect of PPARγ2 Polymorphism and NSAIDs on Acute Alcohol-induced Changes in Serum Estrogens Among Post-menopausal Women
Postmenopausal women, stratified by a peroxisome proliferator-activated receptor gamma-2 (PPARG) polymorphism, were given the following treatments in a random order with a 5w wash-out period: a 400mg ibuprofen tablet or a placebo…
- Trial name
- EPPNASE (NCT02463383)
- Testing
- Ibuprofen Tab 400 MG
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Professor Lars Ove Dragsted
Acute Myocardial Infarction: Rehabilitation Phase
Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute MI
Ischemic heart disease remains the leading cause of death in the western world. The beneficial effects of cardiac rehabilitation on the evolution of ischemic heart disease are known, but the effects of rehabilitation on the…
- Trial name
- RIABILITOMICA (NCT06298513)
- Testing
- Cardiac rehabilitation
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Auxologico Italiano
Protein Feeding in Post-traumatic Injury Patients
Early and Adequate Protein Feeding Post-Traumatic Injury
A randomized, parallel-group, pilot study comparing the effect of the early addition of intravenous protein to enteral feeding as tolerated versus enteral feedings as tolerated alone immediately post traumatic injury.
- Trial name
- EMS (NCT02837861)
- Testing
- Routine Nutritional Support plus supplemental IV amino acids, Routine Nutritional Support
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Boston Medical Center
Autoimmune Diseases
Personalized Management of Autoimmune Diseases With AI-Guided (GenAIS TM) Dietary Supplementation
The study "Personalized Management of Autoimmune Diseases with AI-Guided (GenAIS TM) Dietary Supplementation" investigated the effectiveness of AI-guided dietary supplement (DS) prescriptions compared to standard physician-guided…
- Trial name
- NCT06470412
- Testing
- Control group, AI-Guided Group
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- S.LAB (SOLOWAYS)