Clinical trials: Metagenome
Attention-deficit/Hyperactivity Disorder
Gut Microbiome and Serum Metabolome Alterations in ADHD Patients
Host-microbe interactions play a key role in brain development and function and in the etiology of neurodevelopmental disorders.
- Trial name
- ADHD (NCT03447223)
- Where
- China
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Diabetic Foot Osteomyelitis, Diabetic Foot Infection
Studying on the Difference Between Two Kinds of Osteomyelitis
To explore the microbial differences of diabetic foot osteomyelitis and osteomyelitis without diabetes.
- Conditions
- Diabetic Foot Osteomyelitis, Diabetic Foot Infection, Microbiome
- Trial name
- NCT04240964
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Circadian Rhythm Disorders, Intestinal Flora
An Observational Clinical Study on the Intestinal Flora in Circadian Rhythm Disorder and Healthy Controls
An observational clinical study on the changes of intestinal flora between people with circadian rhythm disorders and healthy controls was conducted to explore the relationship between circadian rhythm disorders and human…
- Trial name
- NCT05694481
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Rheumatoid Arthritis
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic and potentially severe autoimmune disease affecting 2 million in the United States. The role of environmental factors in modulating autoimmunity pathogenesis has been clearly described and…
- Trial name
- NCT02544334
- Testing
- Dental Plaque, Multi-dimensional health assessment questionnaire (MDHAQ), Saliva Collection
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Florida
Gastrointestinal Lymphoma
A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients
This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.
- Trial name
- NCT03930043
- Testing
- Metagenomic shotgun sequencing
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Microbiota, Antibiotic Disruption
Antibiotic-induced Disruption of the Microbiota
The use of antibiotics causes profound changes in the microbiota. However, the magnitude of the effect of intrapartum and early-life antibiotics on the breast milk and the infant oral and intestinal microbiota, and whether…
- Trial name
- ABERRANT (NCT04091282)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Hepatocellular Carcinoma
Tumor Antigen Discovery for Innovative Cancer Immunotherapies in HCC: from Benchside to Bedside (HepAnt)
Tumor Antigen Discovery for Innovative Cancer Immunotherapies in HCC: From Benchside to Bedside (HepAnt) - Study of the Role of the Metagenome in Head and Neck Tumors Using Omics Techniques (HeNomics).
- Trial name
- NCT06905262
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute, Naples
Obesity, Sarcopenia
Pilot Study of the Human Metagenome in Metabolic Diseases
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia.
- Conditions
- Obesity, Sarcopenia, Sarcopenic Obesity, Chronic Inflammation
- Trial name
- NCT06363253
- Testing
- No specific intervention
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Rectal Neoplasms, Colon Neoplasms
Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer
Colorectal cancer (CRC) is one of the most common and deadly cancers worldwide. About 1 in 4 people with CRC already have cancer spread (metastasis) when first diagnosed, and about half develop spread during their illness.
- Conditions
- Rectal Neoplasms, Colon Neoplasms, Microbiota, Metagenome
- Trial name
- NCT07154173
- Testing
- Biospecimen Collection Procedure
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Microbial Colonization, Microbial Superinvasion
Metagenomic Analysis of Gut Microbiome in Preterm
This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and…
- Conditions
- Microbial Colonization, Microbial Superinvasion, Microbial Substitution, Newborn Morbidity
- Trial name
- MAGMP (NCT03235635)
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Wonju Severance Christian Hospital
Human Microbiome, Metagenome
Changes in Vaginal, Cervical and Uterine Microflora With Levonorgestrel Intrauterine Device Placement
The goal of this study is to examine changes in the bacterial ecology and inflammatory markers of the female genital tract with levonorgestrel intrauterine device placement.
- Conditions
- Human Microbiome, Metagenome, Contraception, Cytokine
- Trial name
- NCT01496898
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Utah
Age Related Macular Degeneration
The Role of the Gut Metagenome on the Development of Age Related Macular Degeneration (AMD)
The primary objective of this study is to assess whether compositional and functional alterations of the gut metagenome may be related to AMD.
- Trial name
- NCT02438111
- Testing
- metagenome
- Where
- Switzerland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Transfemoral Amputation
Microbiome and Metagenome in Percutaneous Osseointegrated Prostheses (MMPOP)
The purpose of this study is to investigate the clinical implementation of a new percutaneous prosthetic attachment system by determining the resident microbial ecology of the implant exit site and to simultaneously study the…
- Trial name
- MMPOP (NCT02564432)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Obesity
Inter-relationships Among Glucose, Brain, Gut Microbiota and MicroRNAs (IRONmiRNA).
The brain is a recognized target of iron deposition. This process is enhanced by the presence of obesity and hyperglycemia and impacts cognitive functions.
- Trial name
- IRONmiRNA (NCT05345106)
- Testing
- Bariatric Surgery
- Where
- Spain
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Crohn Disease, Pediatric Crohns Disease
Personalized AZithromycin/metronidAZole Therapy in Pediatric Crohn's Disease (CD)
This is a multi-center, randomized, controlled open-label add-on design trial pilot study to evaluate the efficacy of personalized adjunctive antibiotic (azithromycin + metronidazole) therapy in pediatric subjects with mild to…
- Trial name
- PAZAZ (NCT04186247)
- Testing
- Azithromycin, Metronidazole, Standard of Care
- Where
- 5 sites in United States, Canada and 2 more
- Volunteers
- 13 people
- Sponsor
- University of North Carolina, Chapel Hill
Dry Eye Disease
The Ocular Microbiome in Patients With Dry Eye Disease
The primary objective of this study is the characterization of the ocular microbiome in a healthy cohort and in patients with dry eye disease using whole-metagenome shotgun sequencing.
- Trial name
- NCT04656197
- Testing
- Ocular microbiome
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Aging
A Model for Healthy Aging: Moscow Centenarians (AGE-100)
This study evaluates the associations between biomarkers of ageing, comprehensive geriatric status, telomere length and progerin level, the composition of the gut microbiota, 16sRNA metagenome sequencing in Moscow centenarians.
- Trial name
- AGE-100 (NCT02876809)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Pirogov Russian National Research Medical University
Non Small Cell Lung Cancer, Microbiome
BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics
The goal of the project is to develop and validate the BioForte technology. Its main functionality should be to in silico determine candidates for novel microbiome-based therapeutics and diagnostics.
- Conditions
- Non Small Cell Lung Cancer, Microbiome, Metagenome, Immunotherapy
- Trial name
- NCT04136470
- Testing
- Collection of stool, blood (PBMC) and biopsy (FFPE)
- Where
- 10 sites in Poland
- Volunteers
- 130 people
- Sponsor
- Ardigen
Dietary Fiber, Gastrointestinal Microbiome
Luxembourgish Fiber Cohort
Many human populations across the world are deficient in the intake of dietary fiber. This decline in fiber consumption parallels an increase in prevalence of a multitude of diseases (e.g. colorectal cancer, multiple sclerosis).
- Conditions
- Dietary Fiber, Gastrointestinal Microbiome, Healthy Volunteers
- Trial name
- Lux-FiCo (NCT04352231)
- Testing
- High Fiber Diet Intervention, Low Fiber Diet Intervention
- Where
- 2 sites in Luxembourg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health