Clinical trials: Metaplasia
Gastric Intestinal Metaplasia
Efficacy and Safety of Berberine for Gastric Intestinal Metaplasia
The goal of this clinical trial is to investigate the efficacy of Berberine in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults. It will also learn about the safety of Berberine.
- Trial name
- NCT07129460
- Testing
- Berberine hydrochloride
- Volunteers
- 204 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Barretts Esophagus With Low Grade Dysplasia, Dysplasia
Acetic Acid for the Detection of Esophageal Neoplasms
Barrett's esophagus is a complication of chronic gastroesophageal reflux disease that occurs in up to 10% to 15% of patients with this pathology.
- Conditions
- Barretts Esophagus With Low Grade Dysplasia, Dysplasia, Intestinal Metaplasia
- Trial name
- NCT04054713
- Testing
- Acetic acid chromoendoscopy, Seattle protocol
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Gastric Cancer, Gastric (Stomach) Cancer
Gastric Cancer Endoscopic Screening in an Intermediate-risk Country - ROGCAS, a Dual-centre Pilot Program
Endoscopic screening of gastric cancer combined with screening colonoscopy
- Conditions
- Gastric Cancer, Gastric (Stomach) Cancer, Atrophic Gastritis, Intestinal Metaplasia of Gastric Mucosa
- Trial name
- ROGCAS (NCT06316882)
- Testing
- Screening endoscopy
- Where
- Portugal
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Unidade Local De Saúde Do Norte Alentejano
Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence
Validation the Artificial Intelligence System for Automatic Evaluation of the Extent of Intestinal Metaplasia
The operative link on gastric intestinal metaplasia assessment (OLGIM) staging systems using biopsy specimens were commonly used for histological assessment of gastric cancer risk.
- Conditions
- Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence, Endoscopy
- Trial name
- NCT05464108
- Testing
- The diagnosis of Artificial Intelligence and endosopists
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Shandong University
Intestinal Metaplasia of Gastric Mucosa
Intestinal Metaplasia Cohort for Gastric Cancer Prediction
In this study, we aim to establish a prospective cohort of patients with endoscopically and histologically confirmed intestinal metaplasia, collect gastric mucosal tissue samples from this cohort, and follow the development of…
- Trial name
- NCT06075199
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Gastric Intestinal Metaplasia
Metformin Efficacy and Safety for Gastric Intestinal Metaplasia
Gastric intestinal metaplasia significantly increases the risk of gastric cancer. Metformin, a biguanide, which is widely used for treating diabetes mellitus, has recently been suggested to have a suppressive effect on…
- Trial name
- NCT05288153
- Testing
- Metformin, Folate
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Intestinal Metaplasia
Atrophic Gastritis and OLGIM Stage
Three clinical research coordinators recruited patients aged 40-75 who underwent screening endoscopy at the Digestive Endoscopy Center of Qilu Hospital from July 1, 2022, to July 30, 2024.
- Trial name
- NCT06585553
- Where
- China
- Volunteers
- 2,121 people
- Sponsor
- Shandong University
Gastric Cancer, Metaplasia
Reversal of Preneoplastic Metaplasia in the Stomach With MEK Inhibitor
This is a study of the safety and effectiveness of Trametinib treatment in patients who have received successful endoscopic submucosal resection of a Stage I gastric cancer.
- Conditions
- Gastric Cancer, Metaplasia, Stage I Gastric Cancer, Initial-onset Gastric Cancer
- Trial name
- NCT04454476
- Testing
- Trametinib treatment, Endoscopy
- Where
- 3 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Gastric Cancer, Gastric Intestinal Metaplasia
Cytosponge for Gastric Intestinal Metaplasia
Gastric cancer has a very poor prognosis. The disease is often diagnosed at a late stage, when curative treatment options are limited or ineffective.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy
- Trial name
- CyGIM (NCT05657080)
- Testing
- Cytosponge-TFF3
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- University of Cambridge
Gastric Xanthoma, Helicobacter Pylori Infection
A Study on the Relationship Between Gastric Xanthoma and Gastric Cancer and Precancerous Lesions
To explore the effects of gastric xanthoma on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Gastric Xanthoma, Helicobacter Pylori Infection, Gastric Cancer, Intestinal Metaplasia
- Trial name
- NCT06282484
- Where
- China
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastritis H Pylori, Gastritis Chronic
Evaluation of Antral Biopsies Obtained in Normal Esophagogastroduodenoscopy
Esophagogastroduodenoscopy (EGD) is commonly performed in patients presenting with abdominal pain and dyspeptic symptoms, serving as a valuable diagnostic and therapeutic tool.
- Conditions
- Gastritis H Pylori, Gastritis Chronic, Intestinal Metaplasia
- Trial name
- NCT06269380
- Testing
- Esophagogastroduodenoscopy, Endoscopic biopsy sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 671 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Ulcerative Colitis, Crohn Disease
Systems Biology of Gastrointestinal and Related Diseases
This is a longitudinal observational study on patients with gastrointestinal and related disease. The study will be conducted for at least 10 years, following each participant over time, as they either go through relapses and…
- Conditions
- Ulcerative Colitis, Crohn Disease, Obesity, Colon Polyp
- Trial name
- NCT05579444
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Viome
Stomach Neoplasm, Chronic Atrophic Gastritis
The Gastric HormonE BioMarkers of Preneoplastic Lesions Study
The goal of the study is to understand whether blood levels of hormones produced or metabolized in the stomach reflect the health of the stomach lining.
- Conditions
- Stomach Neoplasm, Chronic Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- GEM (NCT06085677)
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Autoimmune Diseases, Helicobacter Pylori Gastritis
Pyloric or Pseudopyloric Metaplasia of the Corpus Mucosa in Autoimmune Gastritis
The study is aimed to investigate the different rates of pyloric/ pseudopyloric metaplasia or spasmolytic polypeptide-expressing metaplasia (SPEM) of corpus between autoimmune gastritis and H. pylori-infected non-ulcer dyspepsia.
- Conditions
- Autoimmune Diseases, Helicobacter Pylori Gastritis, Anemia, Pernicious, Metaplasia
- Trial name
- PM_in_AIG (NCT05238181)
- Testing
- Assess pyloric or pseudopyloric metaplasia of corpus by H&E stains, Assess pyloric or pseudopyloric metaplasia of corpus by TFF2 immunohistochemistry stains, The assessment of corpus-predominant gastritis index (CGI), Operative Link for Gastritis Assessment (OLGA), and Operative Link on Gastric Intestinal Metaplasia assessment (OLGIM)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Appendicitis, Intestinal Metaplasia
Intestinal Flora and Metabonomics of Appendicitis
The goal of this observational study is to learn about the key bacterial flora and metabolites associated with appendicitis in children.
- Conditions
- Appendicitis, Intestinal Metaplasia, Metabonomics
- Trial name
- NCT06035029
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- HongyiQu
Gastric Cancer, Atrophic Gastritis
AG & IM in CA Stomach Protocol
This is a multi-center prospective case control study aiming to compare different methods of risk stratification models in predicting the risk of gastric cancer development.
- Conditions
- Gastric Cancer, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT04184960
- Testing
- Gastroscopy and gastric biopsies
- Where
- 4 sites in Hong Kong, Japan and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Gastric Intestinal Metaplasia, Artificial Intelligence
Automatic Evaluation of the Severity of Gastric Intestinal Metaplasia With Pathology Artificial Intelligence Diagnosis System
The OLGIM staging system is highly recommended for a comprehensive assessment of GIM severity to evaluate patients' gastric cancer risk.
- Conditions
- Gastric Intestinal Metaplasia, Artificial Intelligence, Pathology, Gastric Cancer
- Trial name
- NCT05447221
- Testing
- The diagnosis of Artificial Intelligence and pathologists
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia, Treatment
RFA for GIM Treatment
Use radiofrequency ablation (RFA) for Gastric intestinal metaplasia (GIM) treatment.
- Conditions
- Gastric Intestinal Metaplasia, Treatment, Radio-frequency Ablation
- Trial name
- NCT04348266
- Testing
- Radiofrequency ablation (RFA)
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Barrett's Esophagus, Intestinal Metaplasia
The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE
Detections of goblet cells and dysplasia are crucial for diagnosis and determining the surveillance program of Barrett's esophagus (BE).
- Trial name
- NCT05818072
- Testing
- One biopsy, Three biopsy, Seattle protocol
- Where
- Taiwan
- Volunteers
- 165 people
- Sponsor
- E-DA Hospital
Narrow-band Imaging, Magnifying Endoscopy
Endoscopic Grading of Intestinal Metaplasia
Long-term Helicobacter pylori infection causes premalignant gastric conditions, such as atrophic gastritis and intestinal metaplasia.
- Conditions
- Narrow-band Imaging, Magnifying Endoscopy, Gastric Intestinal Metaplasia
- Trial name
- NCT05345314
- Testing
- Narrow-band imaging endoscopy
- Where
- South Korea
- Volunteers
- 242 people
- Sponsor
- Soonchunhyang University Hospital