Clinical trials: Metaplasia
Gastric Intestinal Metaplasia
The Value of Black Spots in Diagnosing Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The study aims to: 1. Explore the properties of mesenchymal black spots, and to determine the value of mesenchymal black spots in diagnosing gastric intestinal metaplasia by confocal laser endomicroscopy (CLE). 2.
- Trial name
- NCT01646528
- Testing
- CLE examination for upper gastrointestinal tract
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia, Gastric Intraepithelial Neoplasia
Confocal Laser Endomicroscopy for the Diagnosis of Gastric Intestinal Metaplasia, Intraepithelial Neoplasia, and Carcinoma
i. To determine whether Confocal Laser Endomicroscopy (CLE) with optical biopsy and targeted mucosal biopsy improves the diagnostic yield of gastric IM/IN/CA in high risk populations compared to WLE with standard biopsy protocol.
- Conditions
- Gastric Intestinal Metaplasia, Gastric Intraepithelial Neoplasia, Gastric Carcinoma
- Trial name
- NCT01642797
- Testing
- Confocal laser endomicroscopy (Pentax, EG3870K), Standard White-light endoscopy (Pentax, 90i)
- Where
- 4 sites in Australia, China and 1 more
- Volunteers
- 242 people
- Sponsor
- Shandong University
Intestinal Metaplasia
Confocal Laser Endomicroscopy for the Detection of Gastric Intestinal Metaplasia: a Randomized Controlled Trial
The purpose of this study is to assess whether confocal laser endomicroscopy can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.
- Trial name
- NCT01024621
- Testing
- Endomicroscope, Standard endoscopy
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Shandong University
Intestinal Metaplasia, Intestinal Dysplasia
Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy
The investigators hypothesis that 1. clinical applicability and overall diagnostic sensitivity and specificity of pCLE for diagnosing gastric preneoplastic and neoplastic lesions is acceptable 2.
- Trial name
- pCLE-GCEP (NCT01398579)
- Testing
- Gastroscopy
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Gastric Intestinal Metaplasia
The Predictive Scores for Gastric Cancer in Gastric Intestinal Metaplasia (GIM) Patient: a Recommendation for Thai Population
The predictive scores for gastric cancer in gastric intestinal metaplasia(GIM) patient: a recommendation for Thai population. Objective: To evaluate major risk factors for gastric cancer in gastric intestinal metaplasia(GIM)…
- Trial name
- NCT01490541
- Where
- Thailand
- Volunteers
- 280 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Acute Myelogenous Leukemia, Agnogenic Myeloid Metaplasia
PTK 787 and Gleevec in Patients With AML, AMM, and CML-BP
The goal of this clinical research study is to find the highest safe doses of PTK 787 (vatalanib) and Gleevec (imatinib mesylate) that can be given to treat Chronic Myelogenous Leukemia-Blastic Phase (CML-BP), Refractory Acute…
- Conditions
- Acute Myelogenous Leukemia, Agnogenic Myeloid Metaplasia, Chronic Myelogenous Leukemia
- Trial name
- NCT00088231
- Testing
- Imatinib Mesylate (Gleevec), PTK 787 (vatalanib)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Intestinal Metaplasia
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) Images Interpretation in Gastric Intestinal Metaplasia (GIM)
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) images interpretation in Gastric Intestinal Metaplasia (GIM) Objective: The aim of this study is to evaluate the learning curve of pCLE images interpretation…
- Trial name
- NCT01491724
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastric Intestinal Metaplasia
Confocal Endomicroscopy Detection of Gastric Preneoplasia and Neoplasia
This is a prospective randomised study investigating the use of chromoendoscopy and confocal laser endomicroscopy for the detection of preneoplastic neoplasm in patients at high-risk of gastric cancer.
- Trial name
- R-CE-GCEP (NCT01384201)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Esophageal Metaplasia
Esophageal Metaplasia Using a Novel Antibody: Reversibility by Proton Pump Inhibitor
In this project, we are trying to identify patients with the earliest signs of abnormality in the lining of the lower part of the food pipe (or esophagus) known as intestinal metaplasia (IM); also commonly called Barrett's…
- Trial name
- NCT00161200
- Testing
- Ranitidine & Pantoprazole
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Hematological Malignancies, Myelodysplasia
A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies
The main objectives of this study are to evaluate the side effects of MKC-1 and to determine a safe dose of MKC-1 for future studies in patients with hematological malignancies
- Conditions
- Hematological Malignancies, Myelodysplasia, Agnogenic Myeloid Metaplasia
- Trial name
- NCT00506402
- Testing
- MKC-1
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- CASI pharmaceuticals, Inc.