Clinical trials: Metastases, CNS
Postdural Puncture Headache
Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches
Postdural puncture headache (PDPH) is a severe, debilitating complication of dural puncture that can arise from insertion of an epidural or spinal needle for labour analgesia.
- Trial name
- SPGB (NCT04515901)
- Testing
- 2% lidocaine
- Where
- Canada
- Sponsor
- McMaster University
Non-small Cell Lung Cancer, Brain Metastases
Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer.
The goal of this interventional phase III clinical trial is to evaluate objective intracranial response rate (iORR) after a treatment with total cranial radiation therapy plus concomitant transdermal nitroglycerin (NTG) addition…
- Conditions
- Non-small Cell Lung Cancer, Brain Metastases, EGFR Gene Mutation
- Trial name
- NCT06238882
- Testing
- Nitroglycerin
- Where
- Mexico
- Volunteers
- 74 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Epilepsies, Partial
Safety and Tolerability of Intravenous SPM 927 as Replacement for Oral SPM 927 in Subjects With Partial Seizures
Subjects enrolled in the SP615, SP756, or SP774 open-label extension (OLE) trials receiving oral SPM 927 for at least 8 weeks and a stable dose of up to 3 antiepileptic medications may participate in a research trial at…
- Trial name
- NCT00151879
- Testing
- SPM 927
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- UCB Pharma
Post-Traumatic Headache, Concussion, Mild
Clinical Characteristics and Pathophysiology of Post-Traumatic Headache
To better understand the clinical characteristics and complex pathophysiological events that constitute persistent post-traumatic headache (PPTH) and to identify possible calcitonin gene-related peptide (CGRP) hypersensitivity in…
- Trial name
- NCT03791515
- Testing
- Calcitonin Gene-Related Peptide
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Headache Disorders, Tension-Type Headache
An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache Patients
Headache disorders are among the most prevalent medical conditions worldwide. The diagnosis of headache disorders is based on medical history taking.
- Conditions
- Headache Disorders, Tension-Type Headache, Migraine Disorders, Cluster Headache
- Trial name
- NLPH-OPEN (NCT05153876)
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 1,150 people
- Sponsor
- University Hospital, Ghent
Secondary Progressive Multiple Sclerosis
Dose Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the Cerebrospinal Fluid (CSF)and Safety in Subjects With Secondary Progressive Multiple Sclerosis (SPMS)
This is a prospective, randomized, multicenter, dose escalation study to determine subject safety, pharmacokinetic, and pharmacodynamic responses in patients with SPMS
- Trial name
- NCT01181089
- Testing
- Baminercept
- Sponsor
- Biogen
Secondary-progressive Multiple Sclerosis
Safety Study of Human Neural Stem Cells Injections for Secondary Progressive Multiple Sclerosis Patients
This will be a phase I, open, multicenter, international study performed by 3 participating centres across two countries (Italy and Switzerland).
- Trial name
- NSC-SPMS (NCT03282760)
- Testing
- Human Neural Stem Cells
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 24 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Brain and Central Nervous System Tumors
LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases
RATIONALE: LMB-7 immunotoxin can locate tumor cells and kill them without harming normal cells. PURPOSE: Phase I trial to study the effectiveness of LMB-7 immunotoxin in treating patients who have leptomeningeal metastases…
- Trial name
- NCT00003020
- Testing
- LMB-7 immunotoxin
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Diffuse Large B-Cell Lymphoma, Drug Toxicity
Reduction of MTX Levels After Glucarpidase Treatment in DLBCL Patients at Risk of CNS
Diffuse large B-cell lymphoma (DLBCL) is an aggressive subset of non-Hodgkin's lymphoma (NHL). Central nervous system (CNS) involvement in patients with NHL is a serious complication.
- Trial name
- NCT05022797
- Testing
- Glucarpidase 1000 UNT [Voraxaze]
- Where
- 2 sites in Spain
- Volunteers
- 3 people
- Sponsor
- Fundacion CRIS de Investigación para Vencer el Cáncer
Diplegic Cerebral Palsy
Diplegic Cerebral Palsy and Action Observation Training
In this study, video-based action observation training and live action observation training in children with spastic diplegic cerebral palsy; It was aimed to examine the effect on motor function, activity participation and…
- Trial name
- NCT05209282
- Testing
- Video Based Action Observation, Live Action Observation, Conventional physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Inonu University
Post-Dural Puncture Headache
Effectiveness of Nebulized Dexmedetomidine for Treatment of Obstetric Post-Dural Puncture Headache
Postdural puncture headache (PDPH) is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia.
- Trial name
- NCT04327726
- Testing
- Dexmedetomidine Nebulization, 0.9% Saline Nebulization
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Zagazig University
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS
The purpose of this study is to examine the effect of treatment with fampridine in patients with secondary progressive MS (SPMS) or primary progressive MS (PPMS) with upper limb dysfunction (as defined by a 9-HPT time of between…
- Trial name
- NCT02208050
- Testing
- Fampridine
- Where
- 2 sites in Ireland
- Volunteers
- 64 people
- Sponsor
- University College Dublin
Leptomeningeal Metastases
Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases
With the rapid development of targeted drugs, the treatment of patients with leptomeningeal metastasis has become a very difficult problem in clinical work.
- Trial name
- NCT06861218
- Testing
- pemetrexed, vometinib
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Zhejiang Cancer Hospital
Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor
Melphalan in Patients With Neoplastic Meningitis
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of melphalan in patients with persistent or recurrent…
- Conditions
- Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor, Leukemia, Lymphoma
- Trial name
- NCT00002750
- Testing
- melphalan
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Breast Carcinoma, Digestive System Neoplasm
Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study
This phase I trial collects blood samples to investigate the prevalence of changes in genes (genetic mutations) in solid tumor patient populations seeking care at Mayo Clinic Embedded Cancer Center at St. Vincent's Riverside.
- Conditions
- Breast Carcinoma, Digestive System Neoplasm, Malignant Brain Neoplasm, Malignant Central Nervous System Neoplasm
- Trial name
- NCT04456140
- Testing
- Biospecimen Collection, Genetic Counseling, Genetic Testing
- Where
- 2 sites in United States
- Volunteers
- 230 people
- Sponsor
- Mayo Clinic
Spinal Cord Injuries, Blood Pressure Disorders
ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury
Empower BP is a pivotal, interventional, multicenter, prospective, randomized, controlled double-blinded study to evaluate the safety and effectiveness of the ARC-IM System in managing symptomatic blood pressure instability in…
- Trial name
- Empower BP (NCT07147296)
- Testing
- ARC-IM System Implantation, ARC-IM Therapy (Group 1), ARC-IM Therapy (Group 2)
- Where
- 13 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- ONWARD Medical, Inc.
Epilepsy, Simple Partial Seizures
Remegal Fixed Dose as Adjunctive Therapy in Patients With Partial Seizures
The purpose of this study is to determine weather Remegal in fixed dosage 1500 mg/daily is effictive and safe in patients with epilepsy with partial seizures
- Conditions
- Epilepsy, Simple Partial Seizures, Complex Partial Seizures, Partial Seizures With Secondary Generalization
- Trial name
- NCT01749046
- Testing
- Remegal
- Where
- 9 sites in Russia
- Volunteers
- 224 people
- Sponsor
- Valexfarm
Neoplasm Metastasis, Spinal Cord Compression
Metastatic Spinal Cord Compression (MSCC): Treatment Timing and Survival Rate
Patients with metastatic spinal cord compression (MSCC) are treated with different options according to the life expectancy. Survival and surgical outcome can be influenced by surgical timing in MSCC patients treated with…
- Trial name
- NCT02934594
- Testing
- Palliative Decompression
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer, Cognitive/Functional Effects
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Stereotactic radiation therapy can send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Lung Cancer, Metastatic Cancer
- Trial name
- NCT00377156
- Testing
- radiation therapy, stereotactic radiosurgery
- Where
- 64 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cervicogenic Headache
Ischemic Compression Technique Versus Jones Technique in Cervicogenic Headache Patients
The primary objective of the study is to determine the effects of Jones and Ischemic compression technique on pain, range of motion and disability in patients with cervicogenic headache.
- Trial name
- NCT06875869
- Testing
- Jones technique, Ischemic compression therapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
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