Clinical trials: Metastases, CNS
Small-cell Lung Cancer, Brain Metastases
SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC
This phase III trial compares the effect of stereotactic radiosurgery and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the…
- Conditions
- Small-cell Lung Cancer, Brain Metastases, SRS, Stereotactic Radiotherapy
- Trial name
- SHARP (NCT06457906)
- Testing
- Experimental group (SRS/SRT/Hypo-RT), Controled group (HA-WBRT)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Pruritus, Brain Tumor
Prevalence of a Localized or Diffuse Pruritus in a Population With One or Several, Primitive or Secondary, Brain Tumor(s)
The association between the presence of pruritus, especially centrofacial, and the presence of a brain tumor is a widespread notion in the medical community but based on a single publication by Andreev et al.
- Trial name
- PRURI-C (NCT03673878)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Brain Cancer, Neoplasm Metastases
Personalized Cellular Vaccine for Brain Metastases (PERCELLVAC3)
Cancer patients with brain metastases (BM) have poor prognosis. Current treatments produce limited efficacy. Recent advance in cancer immunotherapy has provided important new means to treat cancer patients at advanced stages.
- Trial name
- PerCellVac3 (NCT02808416)
- Testing
- Personalized cellular vaccine
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Guangdong 999 Brain Hospital
Analgesia
Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin
The aim of this study is to compare between oral prednisolone and oral pregabalin in management of PDPH to detect effectiveness of the treatment in reducing severity of PDPH, total rescue analgesic consumption and adverse effects…
- Trial name
- NCT04662125
- Testing
- caffeine, paracetamol tablet, Oral prednisolone, oral pregabalin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hemiplegia, Hemiparesis
Evaluation of the Safety and Performance of the AWAKE Device in Patients With Hemiplegia or Hemiparesis Secondary to Stroke (ACV).
Stroke is a leading cause of disability in adults, with gait impairment being a key functional limitation. Although lower limb exoskeletons are used in rehabilitation, the available evidence focuses on bilateral devices used in…
- Trial name
- VAWAKE (NCT07867847)
- Testing
- Bionic System (AWAKE)
- Volunteers
- 20 people
- Sponsor
- Bionic Mobility Solutions, S.L.
Brain Metastases, Adult, Brain Metastases
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
The spread of cancer to the brain is referred to as brain metastases. Brain metastases are a common complication of cancer. This study is being done to determine whether the use of a new imaging agent, 18F-fluciclovine, is able…
- Conditions
- Brain Metastases, Adult, Brain Metastases, Brain Cancer
- Trial name
- NCT04689048
- Testing
- 18F fluciclovine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baptist Health South Florida
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Metastatic Melanoma, Brain Metastases
Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanoma
Up to 50% of patients with unresectable metastatic melanoma will develop brain metastases during their lifetime. A possible treatment options for patients with brain metastases are surgery and radiotherapy but usually for lesions…
- Trial name
- NCT03728465
- Testing
- Nivolumab, Ipilimumab
- Where
- 11 sites in Germany
- Volunteers
- 6 people
- Sponsor
- University Hospital Tuebingen
Hyperlipidemias, Atherosclerosis
Percentage of Secondary Prevention Patients Treated to Their LDL-C Targets
A cholesterol/lipid profile screening project of high risk patients with hyperlipidaemia (secondary prevention) who already receive cholesterol-lowering therapy.
- Conditions
- Hyperlipidemias, Atherosclerosis, Coronary Heart Disease, Carotid Stenosis
- Trial name
- NCT00536965
- Where
- Austria
- Volunteers
- 951 people
- Sponsor
- AstraZeneca
PCNSL, Secondary Central Nervous System Lymphoma
A Study to Evaluate ICP-022 in Patients With R/R PCNSL and SCNSL
The phase II clinical study is to investigate the safety, tolerability, efficacy and pharmacokinetics of ICP-022.
- Trial name
- NCT04438044
- Testing
- ICP-022
- Where
- 5 sites in China
- Volunteers
- 61 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Subarachnoid Hemorrhage, Aneurysmal
Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage
Aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, which is in part due to the development of secondary brain injury.
- Trial name
- NOX2 (NCT05686265)
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cervicogenic Headache, Proprioceptive Disorders
Manual Therapy vs. Multicomponent Exercise in Cervicogenic Headache
The purpose of this study is to compare the effects of manual therapy and a multicomponent exercise program on suboccipital muscle thickness, joint position sense, pain, central sensitization, balance, and kinesiophobia in…
- Conditions
- Cervicogenic Headache, Proprioceptive Disorders, Neck Pain Musculoskeletal
- Trial name
- NCT07776093
- Testing
- Manual Therapy Protocol, Multicomponent Exercise Program
- Volunteers
- 32 people
- Sponsor
- Pamukkale University
Acute Myeloid Leukemia
Central Nervous System (CNS) Involvement in Acute Myeloid Leukemia (AML)
The present study aims at evaluating the prognostic factors at diagnosis predicting Central Nervous System (CNS) relapse in order to identify a group of patients with higher risk of CNS involvement in which prophylaxis with…
- Trial name
- AML1617 (NCT03410407)
- Testing
- Observation of CNS involvement
- Where
- 14 sites in Italy
- Volunteers
- 21 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Non-Small-Cell Lung Cancer, Brain Metastases
SRT Combined With Anlotinib for the Treatment of Brain Metastases From Non-small Cell Lung Cancer
To evaluate the efficacy and safety of SRT combined with anlotinib in the treatment of limited brain metastases from non-small cell lung cancer.
- Trial name
- NCT06476093
- Testing
- Anlotinib hydrochloride
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Lianyungang
Brain Metastases, Lung Cancer Metastatic
Dendritic Cell Therapy for Brain Metastases From Breast- or Lung Cancer
The study will use an Ommaya reservoir that drains into brain metastases to deliver activated, autolous dendritic cells to the tumor lesion, for patients who are 18 - 75 years old who have brain metastases from either lung cancer…
- Conditions
- Brain Metastases, Lung Cancer Metastatic, Breast Cancer Metastatic
- Trial name
- NCT03638765
- Testing
- DCVax-Direct
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northwest Biotherapeutics
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Malignant Melanoma Stage IV, BRAF V600 Mutation
Vemurafenib Plus Cobimetinib After Radiosurgery in Patients With BRAF-mutant Melanoma Brain Metastases
This is a phase II, open label, non-randomised study of vemurafenib and cobimetinib after radiosurgery in adult patients with BRAFV600-mutant melanoma brain metastases.
- Conditions
- Malignant Melanoma Stage IV, BRAF V600 Mutation, Brain Metastases
- Trial name
- RadioCoBRIM (NCT03430947)
- Testing
- Vemurafenib, Cobimetinib
- Where
- 3 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Technische Universität Dresden
Non-valvular Atrial Fibrillation
Safety and Effectiveness of Apixaban Compared to Warfarin in Secondary Prevention in Patients With Atrial Fibrillation
The purpose of this study are 1) to characterize the primary and secondary prevention patients, 2) to calculate incidence rates of stroke/SE or major bleeding in each cohort and 3) to investigate for Japanese secondary prevention…
- Trial name
- NCT05321810
- Testing
- Apixaban, Warfarin
- Where
- Japan
- Volunteers
- 193,565 people
- Sponsor
- Pfizer
Post-Dural Puncture Headache, Hypotension
Different Approaches of Spinal Anesthesia in Patients Undergoing Cesarean Section
The goal of this clinical trial is to compare different approaches of spinal anesthesia in pregnant females who are having cesarean section.
- Conditions
- Post-Dural Puncture Headache, Hypotension, Spinal Shock, Hematoma
- Trial name
- NCT05637645
- Testing
- Midline Approach, Paramedian Approach, Taylors approach
- Where
- 4 sites in Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bahawal Victoria Hospital Bahawalpur
Metastatic Breast Cancer, Brain Metastases
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
This study is to find out if administration of stereotactic radiosurgery (SRS) given after Nivolumab will improve overall response rate/anti-tumor activity in patients with metastatic breast cancer with brain metastases.
- Trial name
- NCT03807765
- Testing
- Nivolumab, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.