Clinical trials: Metastases, CNS
Brain and Central Nervous System Tumors, Seizure
Levetiracetam in Treating Patients With Seizures Caused by Brain Metastases
RATIONALE: Anticonvulsant drugs, such as levetiracetam, may help control seizures caused by brain metastases. PURPOSE: This clinical trial is studying the side effects and how well levetiracetam works in treating patients with…
- Conditions
- Brain and Central Nervous System Tumors, Seizure, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00415376
- Testing
- levetiracetam, quality-of-life assessment
- Sponsor
- Northwestern University
Cognitive/Functional Effects, Metastatic Cancer
Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery
RATIONALE: Stereotactic radiosurgery may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x rays to kill tumor cells.
- Conditions
- Cognitive/Functional Effects, Metastatic Cancer, Neurotoxicity, Radiation Toxicity
- Trial name
- NCT01372774
- Testing
- stereotactic radiosurgery, whole-brain radiation therapy
- Where
- 37 sites in United States
- Volunteers
- 194 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Lung Adenocarcinoma, Brain Metastases
Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases
The purpose of this study is to determine whether erlotinib plus pemetrexed, cisplatin are effective and safe in treating lung adenocarcinoma with brain metastases.
- Trial name
- NCT01578668
- Testing
- erlotinib, pemetrexed, cisplatin
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Guangzhou Medical University
Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm
SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial
This phase II trial compares the effect of single fraction stereotactic radiosurgery to fractionated stereotactic radiosurgery for the treatment of patients with cancer that has spread to the brain (metastatic brain disease).
- Trial name
- NCT05222620
- Testing
- Questionnaire Administration, Stereotactic Radiosurgery, Magnetic Resonance Imaging
- Where
- 7 sites in United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Brain Metastases
Frameless Stereotactic Radiosurgery for Intact Brain Metastases
This is a randomized study to determine if not treating planning target volume (PTV) margins during radiation therapy worsens progression free survival rates in patients with brain metastases.
- Trial name
- NCT02747303
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Chicago
Cervicogenic Headache
Cervicogenic Headache, Cognitive Dysfunction
The goal of this study was to determine the frequency of cognitive dysfunction in patients with cervicogenic headache. participants will be asked questions to determine their cognitive status at once.
- Trial name
- NCT05572489
- Testing
- visual pain scale Beck depression scale Pain catastrophizing scale Short Form-36 Standard Mini mental test Montreal cognitive assessment scale
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain
Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
This randomized phase III trial compares memantine hydrochloride and whole-brain radiotherapy with or without hippocampal avoidance in reducing neurocognitive decline in patients with cancer that has spread from the primary site…
- Conditions
- Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain, Solid Neoplasm
- Trial name
- NCT02360215
- Testing
- Whole brain radiation therapy with hippocampal avoidance, Memantine, Whole brain radiation therapy
- Where
- 220 sites in United States, Canada
- Volunteers
- 518 people
- Sponsor
- NRG Oncology
Brain Metastases
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy.
- Trial name
- NCT05045950
- Testing
- Memantine -Twice Daily or Extended Release, WBRT utilizing the PRDR technique
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Medical College of Wisconsin
Dizziness, Cervicogenic Headache
Comparing the Effects of Sub-Occipital Myofascial Release With and Without SNAG on People With Cervicogenic Dizziness.
Cervicogenic dizziness is defined as a sensation of rotation, resulting from an alteration of the neck proprioceptive afferents of the upper cervical spine.Sub-occipital Release, a type of Myofascial Release (MFR) is a form of…
- Trial name
- NCT07062809
- Testing
- Sub Occipital Myofascial release and (SNAGS)., Sub Occipital Myofascial release.
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Cervicogenic Headache
Therapeutic Efficacy of Different Wavelengths of Low-Level Laser Therapy in the Treatment of Cervicogenic Headache
This study tests if low-level laser therapy (LLLT) with different light wavelengths can help people with cervicogenic headache, a type of headache caused by neck problems.
- Trial name
- WELL (NCT07163208)
- Testing
- Low-Level Laser Therapy (LLLT), Routine Physical Therapy (RPT)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- University of Lahore
Primary Brain Tumors, Metastatic Malignant Neoplasm to Brain
Study of 4-Demethyl-4-cholesteryloxycarbonylpenclome (DM-CHOC-PEN) in Patients With Brain Tumors
DM-CHOC-PEN is a polychlorinated pyridine cholesteryl carbonate that has demonstrated antineoplastic activities in patients with advanced cancers - melanoma, lung, breast and glioblastoma multiforme (GBM) involving the CNS during…
- Trial name
- DM-CHOC-PEN (NCT02038218)
- Testing
- 4-Demethyl-4-cholestryloxycarbonylpenclomedine
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- DEKK-TEC, Inc.
Aneurysm, AVM
Intraoperative Laser Speckle Contrast Imaging to Assess Blood Flow During Neurosurgery
Cerebral blood flow (CBF) is of paramount importance to human brain function, as the brain relies on a continuous blood supply to meet its energy needs.
- Conditions
- Aneurysm, AVM, Dural Arteriovenous Fistula, Glioma
- Trial name
- LSCI-NSURG (NCT05028400)
- Testing
- Laser speckle contrast imaging (LSCI)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Brain and Central Nervous System Tumors, Metastatic Cancer
Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders
RATIONALE: Learning about the side effects of stereotactic radiosurgery in patients with brain tumors or other brain disorders may help doctors plan treatment and help patients live more comfortably.
- Conditions
- Brain and Central Nervous System Tumors, Metastatic Cancer, Radiation Toxicity
- Trial name
- NCT00255671
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Case Comprehensive Cancer Center
Multiple Sclerosis
Electrical Brain Stimulation for Treatment of Secondary Symptoms in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease associated with physical disability, psychological impairment, and cognitive dysfunction. As a result, the disease burden is high, and treatment options are limited.
- Trial name
- NCT06401928
- Testing
- transcranial direct current stimulation, transcranial direct current stimulation combined with cognitive training
- Where
- Iran
- Volunteers
- 53 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Post-Dural Puncture Headache, Ganglion Sphenopalatine Block
The Effect of Ganglion Sphenopalatine Block (GSP-block) Follow-Up
The purpose of this study is to evaluate the long term effects of the ganglion sphenopalatine block (GSP block) on postdural puncture headache.
- Trial name
- GSP-FOLLOW (NCT05301387)
- Testing
- Ganglion Sphenopalatine Block
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Non-small Cell Lung Cancer
Tiragolumab and Atezolizumab in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC) and Untreated Brain Metastases
This clinical trial is aimed at the evaluation of the safety and clinical activity of tiragolumab in combination with atezolizumab with or without chemotherapy in the first line treatment of metastatic non-squamous NSCLC patients…
- Trial name
- NCT05746481
- Testing
- Tiragolumab, Atezolizumab, Pemetrexed
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Liza Villaruz, MD
Cervicogenic Headache
Mobilization Versus Manipulation for the Treatment of Cervicogenic Headaches
There is currently a gap within the literature as to the effects of a thrust versus non-thrust mobilizations techniques specifically to the upper cervical spine C0-C3 along with home exercise program to help reduce frequency and…
- Trial name
- NCT03919630
- Testing
- Thrust Mobilization, Non-Thrust Mobilizations
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Franklin Pierce University
Solid Tumors, Brain Metastases
18F ML-10 for Early Detection of Response of Brain Metastases to WBRT
The purpose of this study is to evaluate the potential of [18F]-ML-10 to serve as a non-invasive imaging tool for the early detection of apoptosis in brain metastases in response to radiation therapy.
- Trial name
- NCT00791063
- Testing
- 18F ML-10
- Volunteers
- 10 people
- Sponsor
- Aposense Ltd.
Castration-resistant Prostate Cancer, Metastatic Cancer
pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer
This trial will evaluate the use of one versus two DNA vaccines, delivered concurrently with PD-1 blockade using pembrolizumab followed by treatment with pembrolizumab alone, and delivered over a prolonged period of time (for a…
- Conditions
- Castration-resistant Prostate Cancer, Metastatic Cancer, Prostate Cancer
- Trial name
- NCT04090528
- Testing
- pTVG-HP, pTVG-AR, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Madison
Recurrent Melanoma, Stage IV Melanoma
Temozolomide and Thalidomide in Treating Patients With Brain Metastases Secondary to Melanoma
This phase II trial is studying how well giving temozolomide together with thalidomide works in treating patients with brain metastases secondary to melanoma.
- Conditions
- Recurrent Melanoma, Stage IV Melanoma, Tumors Metastatic to Brain
- Trial name
- NCT00072163
- Testing
- temozolomide, thalidomide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
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