Clinical trials: Metastases, CNS
Central Nervous System Neoplasm, Localized Brain Neoplasm
Blood Brain Barrier Differences in Patients with Brain Tumors Undergoing Surgery
This pilot research trial studies blood brain barrier differences in patients with brain tumors undergoing surgery. Studying samples of tissue and blood from patients with brain tumors in the laboratory may help doctors to…
- Conditions
- Central Nervous System Neoplasm, Localized Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain, Recurrent Brain Neoplasm
- Trial name
- NCT03071913
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Mayo Clinic
Brain Metastases
Treatments for Brain Metastases With Poor Prognostic Factors
The goal of this observational study is to learn about treatments in brain metastases with poor prognostic factors. The main questions it aims to answer are: What kind of local treatment provides a survival benefit for patients…
- Trial name
- TBMPPF (NCT05609162)
- Testing
- neurosurgical resection
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-sen University
Patients With a Single Brain Metastasis
Surgery Versus Radiosurgery for the Treatment of Single Brain Metastases
Usually the treatment of a single brain metastasis is surgery or Stereotactic Radiosurgery (SRS). Surgery involves resection of the brain tumor by means of an operation, whereas SRS is treatment consisting of highly focused…
- Trial name
- NCT01295970
- Testing
- Surgery, Stereotactic Radiosurgery
- Sponsor
- University Health Network, Toronto
CNS Metastases
A Brain Metastases Research Platform to Tackle the Challenge of CNS Metastases in Solid Tumours
Despite some encouraging data, systemic treatment of CNS metastases from solid tumors remains experimental. Better knowledge on the evolving epidemiology and biology of BM are key elements for the development of new treatment…
- Trial name
- BrainStorm (NCT04109131)
- Testing
- Samples collection: Plasma, Samples collection: CSF, Samples collection: Non-CNS Metastatic Tumour Tissue
- Where
- 17 sites in Belgium, France and 1 more
- Volunteers
- 600 people
- Sponsor
- Jules Bordet Institute
Non-small Cell Lung Cancer, Leptomeningeal Metastasis
A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis
Leptomeningeal metastasis (LM) is one of the disastrous events when managing advanced Non-small cell lung cancer (NSCLC) due to a grave prognosis.
- Trial name
- NCT02803619
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain
RATIONALE: An Opioid Titration Order Sheet that allows healthcare providers to adjust the dose and schedule of pain medication may help improve pain treatment for patients with cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00666211
- Testing
- educational intervention, Titrated pain management, questionnaire administration
- Where
- 11 sites in United States
- Volunteers
- 98 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
PDPH, Post Dural Puncture Headache
Efficacy of Sphenopalatine Block Compared to Blood Patch in the Management of Post-dural Puncture Headaches
Post-dural puncture headache (PDPH) is an iatrogenic complication following a dural puncture, which may occur after lumbar puncture, spinal or epidural anesthesia.
- Trial name
- BRECHE (NCT07354464)
- Testing
- Sphenopalatine Ganglion Block, Blood patch
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Brain Metastases
Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection
Background. Brain metastases (BM) are the most common intracranial tumor and occur in 20-40% of all oncological patients. The most common primary cancer in brain metastases is lung cancer, followed by melanoma, breast cancer…
- Trial name
- NCT04857905
- Testing
- Microsurgical resection, Gamma Knife radiosurgery
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Leptomeningeal Metastases, Solid Tumors
Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases
This phase II clinical study enrolls patients with leptomeningeal metastases from solid tumors. Participants will receive intrathecal and systemic administration of Trastuzumab Rezetecan.
- Trial name
- ITST-ADC-LM (NCT07833657)
- Testing
- Intrathecal and systemic administration of Trastuzumab Rezetecan
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Jiuda Zhao
Headache, Cervical Pain
Comparison of Kinesiology Taping and Instrument Assisted Soft Tissue Mobilization in Cervicogenic Headache
To compare the effects of kinesiology taping and Instrument Assisted Soft Tissue Mobilization in cervicogenic headache
- Trial name
- NCT05474612
- Testing
- kinesiology taping with conventional therapy, Instrument assisted soft tissue mobilization with conventional therapy
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Brain Metastases, Adult, Non Small Cell Lung Cancer
SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET)
This study aims to evaluate the efficacy of silibinin in preventing recurrence in the brain after complete resection of a brain metastasis (BM) from non-small-cell lung cancer (NSCLC) or breast cancer (BC).
- Conditions
- Brain Metastases, Adult, Non Small Cell Lung Cancer, Breast Cancer
- Trial name
- SILMET (NCT05689619)
- Testing
- Silibinin
- Where
- 6 sites in Italy
- Volunteers
- 70 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Ischemic Stroke, Intracranial Hemorrhages
Registry of Patients With Remote Posterior cErebral Hemorrhage Following Reperfusion Treatment in Ischemic Stroke
Introduction Remote cerebral hemorrhage following reperfusion treatment in ischemic stroke is rare (1.3-3.7% of all treated strokes) and is associated with worse functional and vital prognosis.
- Conditions
- Ischemic Stroke, Intracranial Hemorrhages, Hemorrhagic Transformation Stroke
- Trial name
- HEROES-CAT (NCT05871528)
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Migraine, Migraine With Aura
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- STAR (NCT06414044)
- Testing
- Atogepant 60 mg
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Neoplasm Metastases
Neurocognition After Gamma Knife Radiosurgery for Multiple Brian Metastases
Cancer which spreads to the brain (brain metastases) is a common and significant problem. Historically, whole-brain radiotherapy has been used to treat these patients but has a negative effect on cognition.
- Trial name
- NCT01970644
- Testing
- Gamma knife radiosurgery
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- CancerCare Manitoba
Stroke, Cannabis Use
Prevalence of Strokes Secondary to a Reversible Cerebral Vasoconstriction Attributable to Cannabis Consumption in Young Subjects (≤ 45 Years) Hospitalized for an Ischaemic Stroke
Incidence of strokes has increased these last 20 years in young population. This rise could be linked to alcohol, tobacco or drug use like cannabis.
- Trial name
- CANNASTROKE (NCT03379857)
- Testing
- Drug urinal test
- Where
- 6 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Subarachnoid Hemorrhage, Headache
Efficacy of Percutaneous SPG Block in Aneurysmal SAH
Researchers are trying to develop alternative means to help patients with headache pain secondary to aneurysmal subarachnoid hemorrhage (bleeding about the brain).
- Trial name
- NCT04331938
- Testing
- Regional anesthetic SPG block-bilateral
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Multiple Sclerosis, Primary Progressive Multiple Sclerosis
C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Progressive Multiple Sclerosis Refractory to Standard Therapy
This is a global, multicenter, Phase 1b/2 study evaluating the safety and efficacy of C-CAR168, an autologous anti-CD20/BCMA chimeric antigen receptor T-cell therapy, in participants with progressive multiple sclerosis refractory…
- Conditions
- Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary Progress Multiple Sclerosis (SPMS), Primary Progressive Multiple Sclerosis (PPMS)
- Trial name
- NCT07825389
- Testing
- C-CAR168
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- AbelZeta Inc.
Cancer
Brain Metastasis in Breast Cancer Patients
The purpose of this epidemiologic study is to establish a population-based cohort of women with advanced stage breast cancer which can be used to quantify the frequency and timing of brain metastases, and other distant…
- Trial name
- NCT01077648
- Testing
- Trastuzumab or Lapatinib
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Post-Traumatic Headache
Study of Gammacore Sapphire for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)
The purpose of this single-center, prospective, randomized, double-blind, sham controlled, parallel-group study is to collect clinical data related to the safety and efficacy of vagus nerve stimulation for the acute and…
- Trial name
- NCT04071743
- Testing
- gammaCore Sapphire
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer, Brain Metastases From Breast Cancer
Evaluation of Trop-2 ADC in Breast Cancer Patients With Brain Metastases: A Real-World Study
The goal of this real-world study (RWS) is to evaluate the effectiveness of Trop-2 ADC (sacituzumab govitecan) in treating breast cancer patients with brain metastases, and to understand the safety profile of this drug in real…
- Conditions
- Breast Cancer, Brain Metastases From Breast Cancer, Trop2
- Trial name
- NCT07251868
- Testing
- Sacituzumab Govitecan (SG)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Cancer Hospital & Institute
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