Clinical trials: Metastases, CNS
Ischemic Stroke, Oral Anticoagulation
Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants
The Advancing knowledge in ischemic Stroke PatiEnts on oRal Anticoagulants (ASPERA) study aims to investigate characteristics of ischemic stroke cases occurring in patients on oral anticoagulation for atrial fibrillation (AF) or…
- Conditions
- Ischemic Stroke, Oral Anticoagulation, Atrial Fibrillation (AF), Outcome Assessment
- Trial name
- ASPERA (NCT06823466)
- Where
- 47 sites in Croatia, Denmark and 13 more
- Volunteers
- 200 people
- Sponsor
- University of L'Aquila
Post-Dural Puncture Headache
Bilateral Sphenopalatine Ganglion Block With or Without Bilateral Greater Occipital Nerve Block for Treatment of Obstetric Post-Dural Puncture Headache
Post-dural puncture headache is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia.
- Trial name
- NCT04844229
- Testing
- Bilateral transnasal sphenopalatine ganglion block., Bilateral ultrasound guided greater occipital nerve block.
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Ischemic Stroke, Medication Persistence
Affect of Multiple Health Education on Medication Persistence and Clinical Prognosis of Ischemic Stroke Patients
The study aimed to demonstrate the relationship between secondary prevention medication persistence and clinical prognosis of ischemic stroke patients at 3,6,12 months
- Trial name
- NCT02140619
- Testing
- multiple health education interventions
- Where
- China
- Volunteers
- 3,111 people
- Sponsor
- yongjun wang
Secondary Progressive Multiple Sclerosis (SPMS)
Multiple Sclerosis-Simvastatin Trial 2
Multiple Sclerosis (MS) is a progressive neurological disorder of the brain and spinal cord. It affects approximately 120,000 people in the United Kingdom and 2.5 million people globally.
- Trial name
- MS-STAT2 (NCT03387670)
- Testing
- Simvastatin
- Where
- 31 sites in United Kingdom
- Volunteers
- 964 people
- Sponsor
- University College, London
Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.
This is a Phase 3 extension, global, multicenter study to assess the long-term safety and tolerability of tolebrutinib in adult participants (aged ≥18 years) with RMS, PPMS, or NRSPMS who were previously enrolled in the Phase 2b…
- Conditions
- Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis
- Trial name
- NCT06372145
- Testing
- Tolebrutinib, Teriflunomide
- Where
- 352 sites in United States, Argentina and 45 more
- Volunteers
- 2,500 people
- Sponsor
- Sanofi
Metastatic Malignant Neoplasm in the Brain, Radiation Therapy Recipient
nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex
This trial studies how well nTMS works in planning for stereotactic radiosurgery in patients with brain metastases in the motor cortex.
- Trial name
- NCT04062305
- Testing
- Hand Function Test, Navigated Transcranial Magnetic Stimulation, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Post Traumatic Headache, Chronic Daily Headache
Yoga Training for Returning Veterans With Headache
The objective of the study is to evaluate the efficacy of a yoga treatment for veterans with mild post-traumatic and chronic tension-type headaches.
- Trial name
- NCT01993069
- Testing
- Iyengar-based Yoga Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis, Chronic Progressive
Efficacy of Cyclophosphamide Versus Methylprednisolone in Patients With Secondary Progressive Multiple Sclerosis
Preliminary not-controlled clinical studies of the efficacy of monthly intravenous cyclophosphamide administration in secondary progressive multiple sclerosis reported encouraging results, but no randomized controlled trial has…
- Trial name
- PROMESS (NCT00241254)
- Testing
- Cyclophosphamide (drug), Methylprednisolone (drug)
- Where
- 26 sites in France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Bordeaux
Cognitive/Functional Effects, Metastatic Cancer
Sunitinib Malate After Stereotactic Radiosurgery in Treating Patients With Newly Diagnosed Brain Metastases
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Conditions
- Cognitive/Functional Effects, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00910039
- Testing
- sunitinib malate, cognitive assessment
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Case Comprehensive Cancer Center
NSCLC Stage IV, Brain Metastases
Camrelizumab Combined With Local Treatment in NSCLC Patients With BM
To evaluate the efficacy and safety of Camrelizumab Combined with Chemotherapy and Local Treatment in non-small cell lung cancer with brain metastases.
- Conditions
- NSCLC Stage IV, Brain Metastases, Immunotherapy
- Trial name
- NCT04291092
- Testing
- Immunotherapy, WBRT, Chemotherapy
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Zhejiang Cancer Hospital
TNBC, Brain Metastasis
Sac-TMT Combined With Bevacizumab in TNBC With Brain Metastases
This is a single-arm, multi-center phase II study to evaluate the safety and efficacy Sacituzumab Tirumotecan (Sac-TMT) plus bevacizumab in triple-negative breast cancer patients with brain metastases.
- Trial name
- NCT07623577
- Testing
- Sacituzumab Tirumotecan (Sac-TMT), bevacizumab
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Fudan University
Brain Metastases
GliaSite 1-3 Mets Study
This study has been designed to compile information on the efficacy of the GliaSite RTS combined with radiosurgery in the treatment of newly diagnosed metastatic brain tumors.
- Trial name
- NCT00589212
- Testing
- GliaSite Radiation Therapy System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hologic, Inc.
Central Nervous System Lymphoma
Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed)
The purpose of this research study is to determine the safety of the study drug pemetrexed, and the highest dose of this drug that can be given to people safely.
- Trial name
- NCT00916630
- Testing
- pemetrexed
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Brain Metastases, MRI
Detection and Metabolic Characterization in DOPA PET/CT of Brain Metastases
About 20 to 30% of patients treated for cancer will have brain metastases. These brain metastases are found more frequently in patients with lung cancer, breast cancer or melanoma.
- Trial name
- DOPACER (NCT04890028)
- Testing
- F-DOPA PET/CT
- Where
- 3 sites in France
- Volunteers
- 32 people
- Sponsor
- Institut Cancerologie de l'Ouest
Non-small Cell Lung Cancer, Leptomeningeal Metastasis
Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis
The primary objective of this clinical study is to evaluate the efficacy of high-dose furmonertinib combined with bevacizumab and pemetrexed (triple therapy) in the treatment of non-small cell lung cancer (NSCLC) with…
- Conditions
- Non-small Cell Lung Cancer, Leptomeningeal Metastasis, EGFR Gene Mutation
- Trial name
- NCT06643000
- Testing
- furmonertinib
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Henan Cancer Hospital
Post Dural Puncture Headache
Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients
Some patients develop headache after spinal anesthesia used during cesarean section. This condition is called post-dural puncture headache (PDPH). Early identification of patients at risk may improve patient care.
- Trial name
- NCT07497945
- Testing
- Optic Nerve Sheath Diameter Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Kocaeli University
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer
This phase II trial tests how well craniospinal irradiation (CSI) using photon volumetric modulated arc radiotherapy (VMAT) works in treating patients with breast cancer or non-small cell lung cancer (NSCLC) that has spread from…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Leptomeninges
- Trial name
- NCT06910761
- Testing
- Biospecimen Collection, Craniospinal Irradiation, Electronic Health Record Review
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- City of Hope Medical Center
Post-Dural Puncture Headache
Sphenopalatine Block Versus Greater Occipital Nerve Block in PDPH
Management of postdural puncture headache (PDPH) has always been challenging for anesthesiologists. PDPH not only increases the misery of the patient, but the length of stay and overall cost of treatment in the hospital also…
- Trial name
- NCT05235256
- Testing
- bilateral sphenopalatine ganglion block, bilateral greater occipital nerve block, lidocaine plus dexamethasone
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Astrocytoma, Brain Cancer
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers…
- Conditions
- Astrocytoma, Brain Cancer, Brain Metastases, Bladder Cancer
- Trial name
- NCT04430842
- Testing
- QBS10072S
- Where
- 2 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Quadriga Biosciences, Inc.
Epiduritis, Vertebral Bone Metastasis
Stereotactic Radiotherapy for SPinal Metastases With Limited Extent of Epidural Disease
This study evaluates a new radiation treatment approach for patients with cancer that has spread to the spine (vertebral metastases) and involves limited extension around the spinal cord without causing compression…
- Trial name
- SPEED-RT (NCT07656883)
- Testing
- Stereotactic Body Radiotherapy (SBRT), Conventional External Beam Radiotherapy
- Where
- 14 sites in France
- Volunteers
- 167 people
- Sponsor
- Institut Cancerologie de l'Ouest
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