Clinical trials: Metastases, CNS
Breast Cancer, Metastatic Cancer
Epothilone B in Treating Patients With CNS Metastases From Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as epothilone B, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00450866
- Testing
- epothilone B
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- David Peereboom, MD
Brain Metastasis, Meningeal Metastasis
QH101 Cell Injection in Patients With Brain, Brain (Spinal) Meninges, and Spinal Cord Metastatic Malignant Solid Tumors
QH101 is an allogeneic TCR-enhanced Vδ2 T cell therapy product engineered to express BTN protein-specific binding elements on the cell surface.
- Conditions
- Brain Metastasis, Meningeal Metastasis, Spinal Cord Metastasis
- Trial name
- NCT07656103
- Testing
- QH101 Cell Injection
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Stroke
Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX)
The role of colchicine in the secondary prevention of ischemic stroke has not been determinded. This multicenter, randomized, double-blind, placebo-controlled, event-driven clinical trial of CHANCE-3 EX was aimed to assess the…
- Trial name
- NCT07035405
- Testing
- Colchicine 0.5 mg
- Volunteers
- 7,500 people
- Sponsor
- Beijing Tiantan Hospital
Tumors Metastatic to Brain, Unspecified Adult Solid Tumor, Protocol Specific
Voxel Based Diffusion Tensor Imaging in Predicting Response in Patients With Brain Metastases Undergoing Whole Brain Radiation Therapy or Stereotactic Radiosurgery
This pilot clinical trial studies how well voxel based diffusion tensor imaging in predicting response in patients with brain metastases undergoing whole-brain radiation therapy or stereotactic radiosurgery.
- Trial name
- NCT02277561
- Testing
- diffusion tensor imaging, whole-brain radiation therapy, stereotactic radiosurgery
- Where
- United States
- Sponsor
- Albert Einstein College of Medicine
Autoimmune Diseases of the Nervous System, Multiple Sclerosis
Study of Tcelna (Imilecleucel-T) in Secondary Progressive Multiple Sclerosis
The purpose of this study is to determine whether Tcelna (imilecleucel-T, autologous T-Cell Immunotherapy) is effective in the treatment of secondary progressive multiple sclerosis (SPMS).
- Conditions
- Autoimmune Diseases of the Nervous System, Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Disease Progression
- Trial name
- Abili-T (NCT01684761)
- Testing
- Tcelna
- Where
- 36 sites in United States, Canada
- Volunteers
- 183 people
- Sponsor
- Opexa Therapeutics, Inc.
Migraine, Medication Overuse Headache
Eptinezumab in Adults With Migraine and Medication Overuse Headache
This study evaluates the efficacy of eptinezumab to prevent migraine and headache in patients with the combined diagnosis of migraine and medication overuse headache
- Trial name
- Sunlight (NCT04772742)
- Testing
- Eptinezumab
- Where
- 40 sites in China, Georgia and 3 more
- Volunteers
- 193 people
- Sponsor
- H. Lundbeck A/S
Brain Metastases
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have…
- Trial name
- NCT04246879
- Testing
- MRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Posttraumatic Headache
Hypersensitivity to Adrenomedullin in Post-Traumatic Headache
Adrenomedullin is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether adrenomedullin induces headache with migraine-like features in people with persistent post-traumatic headache (PTH)…
- Trial name
- NCT07059546
- Testing
- Adrenomedullin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Acral Lentiginous Melanoma, Clinical Stage IV Cutaneous Melanoma AJCC v8
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases).
- Conditions
- Acral Lentiginous Melanoma, Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Cutaneous Melanoma, Metastatic Malignant Neoplasm in the Brain
- Trial name
- NCT04511013
- Testing
- Binimetinib, Encorafenib, Ipilimumab
- Where
- 331 sites in United States
- Volunteers
- 112 people
- Sponsor
- SWOG Cancer Research Network
Cervicogenic Headache
Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache
The purpose of this study is to investigate the effect and side-effects of injections with botulinum toxin in neck muscles in cervicogenic headache compared to injections with sodium water.
- Trial name
- NCT00184197
- Testing
- Botulinum toxin
- Where
- Norway
- Volunteers
- 28 people
- Sponsor
- Norwegian University of Science and Technology
Neoplasm Metastasis, Central Nervous System Metastases
Whole Brain Radiation Using IMRT for Patients With Brain Metastases
Some cancers can spread, or metastasize, to the brain. When they do, treatment often involves surgery and/or radiation. Optimal treatment of brain metastases would maximize disease control and minimize toxicity (or side effects)…
- Trial name
- NCT02753790
- Testing
- Intensity Modulated Radiotherapy
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- New Mexico Cancer Research Alliance
Breast Neoplasms, Leptomeningeal Metastasis
Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis
The main purpose of this study is to investigate the efficacy of bevacizumab, etoposide and cisplatin in treating breast cancer patients with central nervous system metastasis (including brain parenchymal and leptomeningeal…
- Conditions
- Breast Neoplasms, Leptomeningeal Metastasis, Brain Metastases
- Trial name
- NCT01281696
- Testing
- Bevacizumab, etoposide, cisplatin, Intrathecal methotrexate
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Brain Metastases
A Trial Evaluating Concurrent Whole Brain Radiotherapy and Iniparib in Multiple Non Operable Brain Metastases
Recent pre-clinical and clinical data have indicated that BSI-201 does not possess characteristics typical of the PARP inhibitor class.
- Trial name
- RAPIBE (NCT01551680)
- Testing
- Radiation combined with iniparib (BSI-201)
- Where
- 3 sites in France
- Volunteers
- 3 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Meningeal Carcinomatosis
Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases
Leptomeningeal metastases (LM) develop when tumor cells reach the cerebrospinal fluid (CSF) and infiltrate the leptomeninges. The median survival of patient with breast cancer and LM is 4-6 months with up to 25% long-term…
- Trial name
- NCT01818713
- Testing
- 2B3-101
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- The Netherlands Cancer Institute
Acute HIV Infection, HIV CNS Involvement
Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis
Primary objective: To compare telmisartan therapy + antiretroviral therapy (ART) versus ART alone during acute Human Immunodeficiency Virus (HIV)a infection in reducing systemic immune activation and trafficking of activated and…
- Trial name
- NCT02750059
- Testing
- TDF/3TC/EFV + Telmisartan, TDF/3TC/EFV only
- Where
- Thailand
- Volunteers
- 21 people
- Sponsor
- SEARCH Research Foundation
Metastatic Cancer
Stereotactic Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Stereotactic radiation therapy may be able to deliver x-rays directly to the tumor and cause less damage to normal tissue.
- Trial name
- NCT00006259
- Testing
- stereotactic radiosurgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Comprehensive Cancer Center
Kidney Cancer, Leukemia
Voriconazole in Preventing Fungal Infections in Children With Neutropenia After Chemotherapy
RATIONALE: Voriconazole may be effective in preventing systemic fungal infections following chemotherapy. PURPOSE: Phase II trial to study the effectiveness of voriconazole in preventing systemic fungal infections in children who…
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00066599
- Testing
- voriconazole
- Where
- 7 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Secondary Progressive Multiple Sclerosis
Functional Electrical Stimulation for Individuals With Secondary Progressive Multiple Sclerosis
Secondary progressive multiple sclerosis (SPMS) is a subtype of multiple sclerosis (MS) for which there are no existing therapies that alter the disease course.
- Trial name
- NCT01647321
- Testing
- Active cycling, Passive cycling
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Brain Metastases, Small Cell Lung Cancer
Hair-sparing Whole Brain Radiotherapy
Up to 10% of patients with cancer will develop symptomatic brain metastases. Given this limited survival it is important to consider quality of life (QOL) when treating these patients.
- Trial name
- NCT01421316
- Testing
- Whole brain radiotherapy with volumetric arc therapy
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- University Hospital, Ghent
Multiple Sclerosis, Secondary Progressive
BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosis
The primary objective of the study is to investigate whether treatment with BG00012 (dimethyl fumarate) compared with placebo slows the accumulation of disability not related to relapses in participants with secondary progressive…
- Trial name
- INSPIRE (NCT02430532)
- Testing
- dimethyl fumarate
- Where
- 18 sites in United States, Belgium and 4 more
- Volunteers
- 58 people
- Sponsor
- Biogen
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